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    Ralgapa1 Ral GTPase activating protein, alpha subunit 1 [ Mus musculus (house mouse) ]

    Gene ID: 56784, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Ralgapa1provided by MGI
    Official Full Name
    Ral GTPase activating protein, alpha subunit 1provided by MGI
    Primary source
    MGI:MGI:1931050
    See related
    Ensembl:ENSMUSG00000021027 AllianceGenome:MGI:1931050
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    GRIPE; Garnl1; Tulip1; mKIAA0884; 2310003F20Rik; 4930400K19Rik
    Summary
    Predicted to enable GTPase activator activity and protein heterodimerization activity. Acts upstream of with a negative effect on negative regulation of DNA-binding transcription factor activity. Located in cytoplasm and nucleus. Is expressed in several structures, including 1st branchial arch; brain; metanephros; placenta; and trunk. Orthologous to human RALGAPA1 (Ral GTPase activating protein catalytic subunit alpha 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 10.1), whole brain E14.5 (RPKM 7.9) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ralgapa1 in Genome Data Viewer
    Location:
    12 C1; 12 24.06 cM
    Exon count:
    45
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (55649673..55868522, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (55602888..55821574, complement)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_32194 Neighboring gene aldolase 1 A, retrogene 2 Neighboring gene insulinoma-associated 2 Neighboring gene STARR-seq mESC enhancer starr_32196 Neighboring gene STARR-seq mESC enhancer starr_32197 Neighboring gene STARR-positive B cell enhancer ABC_E11776 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:56937027-56937210 Neighboring gene breast cancer metastasis-suppressor 1-like Neighboring gene STARR-seq mESC enhancer starr_32198 Neighboring gene predicted gene, 22296

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The RalGAPα1-RalA signal module protects cardiac function through regulating calcium homeostasis. Zhu S, et al. Nat Commun, 2022 Jul 25. PMID 35879328, Free PMC Article
    2. Targeting RalGAPα1 in skeletal muscle to simultaneously improve postprandial glucose and lipid control. Chen Q, et al. Sci Adv, 2019 Apr. PMID 30989113, Free PMC Article
    3. Cloning, genomic structure, and expression profiles of TULIP1 (GARNL1), a brain-expressed candidate gene for 14q13-linked neurological phenotypes, and its murine homologue. Schwarzbraun T, et al. Genomics, 2004 Sep. PMID 15498464
    4. Cloning and characterization of GRIPE, a novel interacting partner of the transcription factor E12 in developing mouse forebrain. Heng JI, et al. J Biol Chem, 2002 Nov 8. PMID 12200424
    5. Identification of a novel member of the snail/Gfi-1 repressor family, mlt 1, which is methylated and silenced in liver tumors of SV40 T antigen transgenic mice. Tateno M, et al. Cancer Res, 2001 Feb 1. PMID 11221845

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The RalGAPalpha1-RalA signal module protects cardiac function through regulating calcium homeostasis.
      Title: The RalGAPα1-RalA signal module protects cardiac function through regulating calcium homeostasis.
    2. interacts with transcription factor E12 in developing forebrain
      Title: Cloning and characterization of GRIPE, a novel interacting partner of the transcription factor E12 in developing mouse forebrain.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (3)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activator activity ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    enables GTPase activator activity ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    enables GTPase activator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in activation of GTPase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_negative_effect negative regulation of DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of small GTPase mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ral GTPase-activating protein subunit alpha-1
    Names
    GAP-related interacting partner to E12
    GTPase activating RANGAP domain-like 1
    GTPase-activating RapGAP domain-like 1
    p240
    ral GTPase-activating protein alpha subunit 1
    tuberin-like protein 1
    tulip 1 protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001003719.3 → NP_001003719.1  ral GTPase-activating protein subunit alpha-1 isoform 3

      See identical proteins and their annotated locations for NP_001003719.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an in-frame exon in the 5' coding region and an internal exon in the 3' region which results in an alternate downstream termination codon, compared to variant 4. The resulting isoform (3) lacks an internal segment but has a longer and distinct C-terminus, compared to isoform 4.
      Source sequence(s)
      AC107633, AC158398, AC159624
      UniProtKB/TrEMBL
      B7ZNA3
      Conserved Domains (1) summary
      pfam02145
      Location:1825 → 2001
      Rap_GAP; Rap/ran-GAP

    2. NM_001112714.3 → NP_001106185.1  ral GTPase-activating protein subunit alpha-1 isoform 2

      See identical proteins and their annotated locations for NP_001106185.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) lacks an in-frame exon in the 5' coding region and a 3 nt exon in the 3' UTR, compared to variant 4. The resulting isoform (2) lacks an internal segment, compared to isoform 4. Variants 1 and 2 encode the same isoform 2.
      Source sequence(s)
      AC107633, AC158398, AC159624
      Consensus CDS
      CCDS36452.1
      UniProtKB/Swiss-Prot
      Q6GYP6, Q6GYP7, Q6ZQ28, Q8BNJ5, Q8C9G8, Q8CIW4, Q9JMC4
      UniProtKB/TrEMBL
      B7ZNA3
      Related
      ENSMUSP00000082503.6, ENSMUST00000085385.7
      Conserved Domains (1) summary
      pfam02145
      Location:1825 → 2001
      Rap_GAP; Rap/ran-GAP

    3. NM_001286263.2 → NP_001273192.1  ral GTPase-activating protein subunit alpha-1 isoform 4

      See identical proteins and their annotated locations for NP_001273192.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) encodes isoform 4.
      Source sequence(s)
      AC107633, AC158398, AC159624
      Consensus CDS
      CCDS88339.1
      UniProtKB/TrEMBL
      A0A1W2P832, B7ZNA3
      Conserved Domains (1) summary
      pfam02145
      Location:1872 → 2048
      Rap_GAP; Rap/ran-GAP

    4. NM_001368814.2 → NP_001355743.1  ral GTPase-activating protein subunit alpha-1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC107633, AC158398, AC159624
      UniProtKB/TrEMBL
      A0A2I3BRX9
      Conserved Domains (1) summary
      pfam02145
      Location:2328 → 2504
      Rap_GAP; Rap/ran-GAP

    5. NM_019994.6 → NP_064378.4  ral GTPase-activating protein subunit alpha-1 isoform 2

      See identical proteins and their annotated locations for NP_064378.4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the 5' coding region, compared to variant 4. The resulting isoform (2) lacks an internal segment, compared to isoform 4. Variants 1 and 2 encode the same isoform 2.
      Source sequence(s)
      AC107633, AC158398, AC159624
      Consensus CDS
      CCDS36452.1
      UniProtKB/Swiss-Prot
      Q6GYP6, Q6GYP7, Q6ZQ28, Q8BNJ5, Q8C9G8, Q8CIW4, Q9JMC4
      UniProtKB/TrEMBL
      B7ZNA3
      Conserved Domains (1) summary
      pfam02145
      Location:1825 → 2001
      Rap_GAP; Rap/ran-GAP

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      55649673..55868522 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006516109.4 → XP_006516172.3  ral GTPase-activating protein subunit alpha-1 isoform X3

      UniProtKB/TrEMBL
      A0A2I3BRX9
      Related
      ENSMUSP00000154749.2, ENSMUST00000226244.2
      Conserved Domains (1) summary
      pfam02145
      Location:2281 → 2457
      Rap_GAP; Rap/ran-GAP

    2. XM_036157540.1 → XP_036013433.1  ral GTPase-activating protein subunit alpha-1 isoform X4

      UniProtKB/TrEMBL
      A0A2I3BRX9
      Conserved Domains (1) summary
      pfam02145
      Location:2281 → 2457
      Rap_GAP; Rap/ran-GAP

    3. XM_006516104.4 → XP_006516167.1  ral GTPase-activating protein subunit alpha-1 isoform X5

      UniProtKB/TrEMBL
      B7ZNA3
      Conserved Domains (1) summary
      pfam02145
      Location:1872 → 2048
      Rap_GAP; Rap/ran-GAP

    4. XM_036157542.1 → XP_036013435.1  ral GTPase-activating protein subunit alpha-1 isoform X7

      UniProtKB/TrEMBL
      A0A1W2P832, B7ZNA3
      Related
      ENSMUSP00000151857.2, ENSMUST00000219432.2
      Conserved Domains (1) summary
      pfam02145
      Location:1872 → 2048
      Rap_GAP; Rap/ran-GAP

    5. XM_030246826.2 → XP_030102686.1  ral GTPase-activating protein subunit alpha-1 isoform X2

      UniProtKB/TrEMBL
      A0A2I3BRX9
      Conserved Domains (1) summary
      pfam02145
      Location:2328 → 2504
      Rap_GAP; Rap/ran-GAP

    6. XM_030246825.2 → XP_030102685.1  ral GTPase-activating protein subunit alpha-1 isoform X1

      UniProtKB/TrEMBL
      A0A2I3BRX9
      Conserved Domains (1) summary
      pfam02145
      Location:2328 → 2504
      Rap_GAP; Rap/ran-GAP

    7. XM_036157544.1 → XP_036013437.1  ral GTPase-activating protein subunit alpha-1 isoform X10

      Conserved Domains (1) summary
      pfam02145
      Location:1102 → 1278
      Rap_GAP; Rap/ran-GAP

    8. XM_036157545.1 → XP_036013438.1  ral GTPase-activating protein subunit alpha-1 isoform X11

      Conserved Domains (1) summary
      pfam02145
      Location:1096 → 1272
      Rap_GAP; Rap/ran-GAP

    9. XM_006516107.4 → XP_006516170.1  ral GTPase-activating protein subunit alpha-1 isoform X8

      UniProtKB/TrEMBL
      A0A1W2P712, B7ZNA3
      Related
      ENSMUSP00000151498.2, ENSMUST00000220367.2
      Conserved Domains (1) summary
      pfam02145
      Location:1825 → 2001
      Rap_GAP; Rap/ran-GAP

    10. XM_036157541.1 → XP_036013434.1  ral GTPase-activating protein subunit alpha-1 isoform X6

      UniProtKB/TrEMBL
      B7ZNA3
      Conserved Domains (1) summary
      pfam02145
      Location:1872 → 2048
      Rap_GAP; Rap/ran-GAP

    11. XM_036157543.1 → XP_036013436.1  ral GTPase-activating protein subunit alpha-1 isoform X9

    RNA

    1. XR_004937530.1 RNA Sequence

    2. XR_004937531.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6GYP7.1 GenPept UniProtKB/Swiss-Prot:Q6GYP7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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