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    Cpa5 carboxypeptidase A5 [ Mus musculus (house mouse) ]

    Gene ID: 74649, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Cpa5provided by MGI
    Official Full Name
    carboxypeptidase A5provided by MGI
    Primary source
    MGI:MGI:1921899
    See related
    Ensembl:ENSMUSG00000029788 AllianceGenome:MGI:1921899
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4930430M09Rik
    Summary
    This gene encodes a member of the carboxypeptidase A family of zinc metalloproteases. The encoded preproprotein undergoes proteolytic processing that removes the N-terminal activation peptide to generate a functional enzyme. This gene is expressed in mouse testes where the encoded protein is localized to the germ cells. This gene is located in a cluster of carboxypeptidase genes on chromosome 6. [provided by RefSeq, Jul 2016]
    Expression
    Restricted expression toward testis adult (RPKM 29.3) See more
    Orthologs
    human all
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    Genomic context

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    See Cpa5 in Genome Data Viewer
    Location:
    6 A3.3; 6 12.52 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (30611009..30631744)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (30611010..30631745)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene carboxypeptidase A4 Neighboring gene predicted gene, 31453 Neighboring gene carboxypeptidase A1, pancreatic Neighboring gene centrosomal protein 41 Neighboring gene predicted gene 13782

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Predicted gene 31453 (Gm31453) and the gene encoding carboxypeptidase A5 (Cpa5) are not essential for spermatogenesis and male fertility in the mouse. Zhou Y, et al. Reprod Fertil Dev, 2021 Apr. PMID 33745502
    2. Identification and characterization of three members of the human metallocarboxypeptidase gene family. Wei S, et al. J Biol Chem, 2002 Apr 26. PMID 11836249
    3. Activated Notch1 prevents differentiation of pancreatic acinar cells and attenuate endocrine development. Hald J, et al. Dev Biol, 2003 Aug 15. PMID 12921743
    4. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Predicted gene 31453 (Gm31453) and the gene encoding carboxypeptidase A5 (Cpa5) are not essential for spermatogenesis and male fertility in the mouse.
      Title: Predicted gene 31453 (Gm31453) and the gene encoding carboxypeptidase A5 (Cpa5) are not essential for spermatogenesis and male fertility in the mouse.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metallocarboxypeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metallocarboxypeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    carboxypeptidase A5
    NP_653120.1
    XP_006505251.1
    XP_006505253.1
    XP_011239386.1
    XP_017177284.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_144537.4 → NP_653120.1  carboxypeptidase A5 preproprotein

      See identical proteins and their annotated locations for NP_653120.1

      Status: REVIEWED

      Source sequence(s)
      AC155656, AK015256, BC138114
      Consensus CDS
      CCDS19976.1
      UniProtKB/Swiss-Prot
      Q8R4H4
      UniProtKB/TrEMBL
      B2RQW9
      Related
      ENSMUSP00000057722.5, ENSMUST00000062758.11
      Conserved Domains (2) summary
      cd03870
      Location:134 → 434
      M14_CPA; Peptidase M14 carboxypeptidase subfamily A/B-like; Carboxypeptidase A subgroup
      pfam02244
      Location:48 → 117
      Propep_M14; Carboxypeptidase activation peptide

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      30611009..30631744
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006505190.4 → XP_006505253.1  carboxypeptidase A5 isoform X1

      See identical proteins and their annotated locations for XP_006505253.1

      UniProtKB/Swiss-Prot
      Q8R4H4
      UniProtKB/TrEMBL
      B2RQW9
      Conserved Domains (2) summary
      cd03870
      Location:134 → 434
      M14_CPA; Peptidase M14 carboxypeptidase subfamily A/B-like; Carboxypeptidase A subgroup
      pfam02244
      Location:48 → 117
      Propep_M14; Carboxypeptidase activation peptide

    2. XM_017321795.1 → XP_017177284.1  carboxypeptidase A5 isoform X1

      UniProtKB/Swiss-Prot
      Q8R4H4
      UniProtKB/TrEMBL
      B2RQW9
      Related
      ENSMUSP00000110792.2, ENSMUST00000115139.8
      Conserved Domains (2) summary
      cd03870
      Location:134 → 434
      M14_CPA; Peptidase M14 carboxypeptidase subfamily A/B-like; Carboxypeptidase A subgroup
      pfam02244
      Location:48 → 117
      Propep_M14; Carboxypeptidase activation peptide

    3. XM_006505188.1 → XP_006505251.1  carboxypeptidase A5 isoform X1

      See identical proteins and their annotated locations for XP_006505251.1

      UniProtKB/Swiss-Prot
      Q8R4H4
      UniProtKB/TrEMBL
      B2RQW9
      Conserved Domains (2) summary
      cd03870
      Location:134 → 434
      M14_CPA; Peptidase M14 carboxypeptidase subfamily A/B-like; Carboxypeptidase A subgroup
      pfam02244
      Location:48 → 117
      Propep_M14; Carboxypeptidase activation peptide

    4. XM_011241084.1 → XP_011239386.1  carboxypeptidase A5 isoform X2

      Conserved Domains (1) summary
      cd03870
      Location:66 → 400
      M14_CPA; Peptidase M14 carboxypeptidase subfamily A/B-like; Carboxypeptidase A subgroup
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8R4H4.1 GenPept UniProtKB/Swiss-Prot:Q8R4H4

    Gene LinkOut

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