Fgf6 fibroblast growth factor 6 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Fgf6provided by MGI
Official Full Name: fibroblast growth factor 6provided by MGI
Primary source: MGI:MGI:95520
See related: Ensembl:ENSMUSG00000000183 AllianceGenome:MGI:95520
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Fgf-6; Fgf7b; HSTF-2
Summary: Predicted to enable fibroblast growth factor receptor binding activity and growth factor activity. Acts upstream of or within cartilage condensation and myoblast differentiation. Predicted to be located in sarcolemma. Predicted to be active in cytoplasm and extracellular space. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; limb; and musculature. Orthologous to human FGF6 (fibroblast growth factor 6). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Low expression observed in reference dataset See more
Orthologs: human all
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Genomic context

Location:: 6 F3; 6 61.92 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (126992505..127001681)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (127015542..127024718)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Skeletal muscle-targeted delivery of Fgf6 protects mice from diet-induced obesity and insulin resistance.
Title: Skeletal muscle-targeted delivery of Fgf6 protects mice from diet-induced obesity and insulin resistance.
Fibroblast growth factor 6 regulates sizing of the muscle stem cell pool.
Title: Fibroblast growth factor 6 regulates sizing of the muscle stem cell pool.
FGF6 and FGF9 are potent inducers of UCP1 expression in adipocytes and preadipocytes.
Title: FGF6 and FGF9 regulate UCP1 expression independent of brown adipogenesis.
A crucial and unexpected role for FGF6 in muscle integrity and muscle protection against mechanical stress.
Title: Eccentric stimulation reveals an involvement of FGF6 in muscle resistance to mechanical stress.
Rescue experiments supported the idea of a specific relationship between FGF6 and Spry 2, both being known for their particular involvement in myogenesis.
Title: Sprouty gene expression is regulated by nerve and FGF6 during regeneration of mouse muscles.
a role for FGF6 in the maintenance of a reserve pool of progenitor cells in the skeletal muscle
Title: FGF6 mediated expansion of a resident subset of cells with SP phenotype in the C2C12 myogenic line.
Involvement of FGF6 in myogenesis. Review.
Title: FGF6 in myogenesis.
In the absence of FGF6, the mechanisms leading to myofibre hypertrophy were mediated specifically by an IGF-II/IGF2R signalling pathway distinct from the classic mechanism involving IGF-I and IGF1R.
Title: IGF-II is up-regulated and myofibres are hypertrophied in regenerating soleus of mice lacking FGF6.
At high doses, FGF6 stimulates the proliferation of the myogenic stem cells, whereas at lower doses it regulates both muscle differentiation and muscle phenotype via a calcineurin-signaling pathway.
Title: FGF6 regulates muscle differentiation through a calcineurin-dependent pathway in regenerating soleus of adult mice.
We show that the combined loss of FGF2 and FGF6 leads to severe dystrophic changes in the musculature.
Title: Reduced mobility of fibroblast growth factor (FGF)-deficient myoblasts might contribute to dystrophic changes in the musculature of FGF2/FGF6/mdx triple-mutant mice.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (2) 1 citation

General gene information

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Markers

Fgf6 (e-PCR), detects polymorphism
- UniSTS:507929

Fgf6 (e-PCR), detects polymorphism
- UniSTS:259610

GDB:214840 (e-PCR)
- UniSTS:156193

D6Uwa1 (e-PCR), detects polymorphism
- UniSTS:142642

Fgf6 (e-PCR), detects polymorphism
- UniSTS:238131

M92416 (e-PCR)
- UniSTS:125000

M92416 (e-PCR)
- UniSTS:159574

Fgf6 (e-PCR), detects polymorphism
- UniSTS:508566

Fgf6 (e-PCR), detects polymorphism
- UniSTS:258272

Fgf6 (e-PCR), detects polymorphism
- UniSTS:143093

Fgf6 (e-PCR), detects polymorphism
- UniSTS:143094

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables fibroblast growth factor receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables growth factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables growth factor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in angiogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cartilage condensation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in fibroblast growth factor receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within fibroblast growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within myoblast differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in neurogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cell division	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell migration	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in sarcolemma	IEA Inferred from Electronic Annotation more info
located_in sarcolemma	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: fibroblast growth factor 6

Names: HBGF-6; HST-2; fibroblast growth factor 7b; heparin secretory-transforming protein 2; heparin-binding growth factor 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.