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    Hemk1 HemK methyltransferase family member 1 [ Mus musculus (house mouse) ]

    Gene ID: 69536, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Hemk1provided by MGI
    Official Full Name
    HemK methyltransferase family member 1provided by MGI
    Primary source
    MGI:MGI:1916786
    See related
    Ensembl:ENSMUSG00000032579 AllianceGenome:MGI:1916786
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2310008M14Rik
    Summary
    Predicted to enable protein-(glutamine-N5) methyltransferase activity and protein-glutamine N-methyltransferase activity. Predicted to be involved in translational termination. Located in mitochondrion. Orthologous to human HEMK1 (HemK methyltransferase family member 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in kidney adult (RPKM 5.0), mammary gland adult (RPKM 4.3) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Hemk1 in Genome Data Viewer
    Location:
    9 F1; 9 58.0 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (107204281..107217640, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (107327082..107340437, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr9:107198795-107199096 Neighboring gene predicted gene 17040 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:107215338-107215525 Neighboring gene cytokine inducible SH2-containing protein Neighboring gene STARR-seq mESC enhancer starr_25171 Neighboring gene RIKEN cDNA 6430571L13 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:107240678-107240861 Neighboring gene STARR-positive B cell enhancer ABC_E6801 Neighboring gene RIKEN cDNA 4930429P21 gene Neighboring gene STARR-seq mESC enhancer starr_25172 Neighboring gene STARR-seq mESC enhancer starr_25173 Neighboring gene calcium channel, voltage-dependent, alpha 2/delta subunit 2 Neighboring gene predicted gene 17141

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    2. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
    3. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
    4. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
    5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-(glutamine-N5) methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-(glutamine-N5) methyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein-glutamine N-methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translational termination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrion HDA PubMed 

    General protein information

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    Preferred Names
    MTRF1L release factor glutamine methyltransferase
    NP_598745.2
    XP_006511887.1
    XP_030100428.1
    XP_036011139.1
    XP_036011140.1
    XP_036011141.1
    XP_036011142.1
    XP_036011143.1
    XP_036011144.1
    XP_036011145.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133984.2 → NP_598745.2  MTRF1L release factor glutamine methyltransferase

      See identical proteins and their annotated locations for NP_598745.2

      Status: VALIDATED

      Source sequence(s)
      AL672070
      Consensus CDS
      CCDS23488.1
      UniProtKB/Swiss-Prot
      B0QZU8, Q921L7
      Related
      ENSMUSP00000035196.8, ENSMUST00000035196.14
      Conserved Domains (1) summary
      TIGR03534
      Location:64 → 333
      RF_mod_PrmC; protein-(glutamine-N5) methyltransferase, release factor-specific

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      107204281..107217640 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036155246.1 → XP_036011139.1  MTRF1L release factor glutamine methyltransferase isoform X1

      UniProtKB/Swiss-Prot
      B0QZU8, Q921L7
      Conserved Domains (1) summary
      TIGR03534
      Location:64 → 333
      RF_mod_PrmC; protein-(glutamine-N5) methyltransferase, release factor-specific

    2. XM_030244568.2 → XP_030100428.1  MTRF1L release factor glutamine methyltransferase isoform X1

      UniProtKB/Swiss-Prot
      B0QZU8, Q921L7
      Conserved Domains (1) summary
      TIGR03534
      Location:64 → 333
      RF_mod_PrmC; protein-(glutamine-N5) methyltransferase, release factor-specific

    3. XM_036155251.1 → XP_036011144.1  MTRF1L release factor glutamine methyltransferase isoform X3

      Conserved Domains (1) summary
      TIGR03534
      Location:1 → 225
      RF_mod_PrmC; protein-(glutamine-N5) methyltransferase, release factor-specific

    4. XM_036155250.1 → XP_036011143.1  MTRF1L release factor glutamine methyltransferase isoform X3

      Conserved Domains (1) summary
      TIGR03534
      Location:1 → 225
      RF_mod_PrmC; protein-(glutamine-N5) methyltransferase, release factor-specific

    5. XM_036155248.1 → XP_036011141.1  MTRF1L release factor glutamine methyltransferase isoform X3

      Conserved Domains (1) summary
      TIGR03534
      Location:1 → 225
      RF_mod_PrmC; protein-(glutamine-N5) methyltransferase, release factor-specific

    6. XM_036155247.1 → XP_036011140.1  MTRF1L release factor glutamine methyltransferase isoform X2

      Conserved Domains (2) summary
      TIGR03534
      Location:107 → 235
      RF_mod_PrmC; protein-(glutamine-N5) methyltransferase, release factor-specific
      pfam17827
      Location:46 → 108
      PrmC_N; PrmC N-terminal domain

    7. XM_006511824.1 → XP_006511887.1  MTRF1L release factor glutamine methyltransferase isoform X3

      See identical proteins and their annotated locations for XP_006511887.1

      Conserved Domains (1) summary
      TIGR03534
      Location:1 → 225
      RF_mod_PrmC; protein-(glutamine-N5) methyltransferase, release factor-specific

    8. XM_036155249.1 → XP_036011142.1  MTRF1L release factor glutamine methyltransferase isoform X3

      Conserved Domains (1) summary
      TIGR03534
      Location:1 → 225
      RF_mod_PrmC; protein-(glutamine-N5) methyltransferase, release factor-specific

    9. XM_036155252.1 → XP_036011145.1  MTRF1L release factor glutamine methyltransferase isoform X4

      Conserved Domains (1) summary
      TIGR03534
      Location:64 → 186
      RF_mod_PrmC; protein-(glutamine-N5) methyltransferase, release factor-specific
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q921L7.2 GenPept UniProtKB/Swiss-Prot:Q921L7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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