Pja2 praja ring finger ubiquitin ligase 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pja2provided by MGI
Official Full Name: praja ring finger ubiquitin ligase 2provided by MGI
Primary source: MGI:MGI:2159342
See related: Ensembl:ENSMUSG00000024083 AllianceGenome:MGI:2159342
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Neurodap1; mKIAA0438
Summary: Predicted to enable protein kinase A catalytic subunit binding activity; protein kinase A regulatory subunit binding activity; and ubiquitin protein ligase activity. Predicted to be involved in several processes, including long-term memory; regulation of macrophage activation; and regulation of signal transduction. Predicted to be located in cytoplasm; cytoskeleton; and plasma membrane. Is expressed in heart ventricle; male reproductive gland or organ; nervous system; and skeletal muscle. Orthologous to human PJA2 (praja ring finger ubiquitin ligase 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in frontal lobe adult (RPKM 42.7), cortex adult (RPKM 39.3) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 E1.1; 17 33.24 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (64588001..64638878, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (64281006..64331883, complement)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Downregulation of praja2 restrains endocytosis and boosts tyrosine kinase receptors in kidney cancer.
Title: Downregulation of praja2 restrains endocytosis and boosts tyrosine kinase receptors in kidney cancer.
Pja2 regulated hippocampal neuronal cell development and the expression of Alzheimer disease marker genes by inhibiting P2rx3/promoting P2rx7 expression.
Title: Regulatory function of praja ring finger ubiquitin ligase 2 mediated by the P2rx3/P2rx7 axis in mouse hippocampal neuronal cells.
praja2 regulates KSR1 stability and mitogenic signaling.
Title: praja2 regulates KSR1 stability and mitogenic signaling.
The SIK2-p35-PJA2 complex is essential for glucose homeostasis and provides a link between p35-CDK5 and the AMPK family in excitable cells.
Title: Role of the SIK2-p35-PJA2 complex in pancreatic β-cell functional compensation.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D17Ium1 (e-PCR), detects polymorphism
- UniSTS:142122

RH125333 (e-PCR)
- UniSTS:162155

NoName (e-PCR)
- UniSTS:237680

AI447901 (e-PCR)
- UniSTS:160683

BB367484 (e-PCR)
- UniSTS:209330

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase A catalytic subunit binding	ISO Inferred from Sequence Orthology more info
enables protein kinase A catalytic subunit binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein kinase A regulatory subunit binding	ISO Inferred from Sequence Orthology more info
enables protein kinase A regulatory subunit binding	ISS Inferred from Sequence or Structural Similarity more info
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin-protein transferase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in inflammatory response	ISS Inferred from Sequence or Structural Similarity more info
involved_in innate immune response	ISO Inferred from Sequence Orthology more info
involved_in innate immune response	ISS Inferred from Sequence or Structural Similarity more info
involved_in long-term memory	ISO Inferred from Sequence Orthology more info
involved_in long-term memory	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of JNK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of JNK cascade	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of p38MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of p38MAPK cascade	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of toll-like receptor 2 signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of toll-like receptor 2 signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IEA Inferred from Electronic Annotation more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in protein ubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in protein ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein ubiquitination	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of macrophage activation	IEA Inferred from Electronic Annotation more info
involved_in regulation of macrophage activation	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein kinase A signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of protein kinase A signaling	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein kinase A signaling	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in centriolar satellite	IEA Inferred from Electronic Annotation more info
located_in centriolar satellite	ISO Inferred from Sequence Orthology more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info
located_in intermediate filament cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in intermediate filament cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in postsynaptic density	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: E3 ubiquitin-protein ligase Praja-2

Names: E3 ubiquitin-protein ligase Praja2; RING finger protein 131; RING-type E3 ubiquitin transferase Praja-2; neurodegeneration associated protein 1; praja 2, RING-H2 motif containing; praja-2; praja2; protein carrying the RING-H2 sequence motif

NP_001020480.1

EC 2.3.2.27

NP_659108.1

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001025309.1 → NP_001020480.1 E3 ubiquitin-protein ligase Praja-2 isoform a

See identical proteins and their annotated locations for NP_001020480.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (a).

Source sequence(s)

AK122282, BY065517

Consensus CDS

CCDS37675.1

UniProtKB/Swiss-Prot

Q3TH95, Q80U04, Q810E3, Q91W46, Q99KC0

Related

ENSMUSP00000134380.2, ENSMUST00000172818.8

Conserved Domains (1) summary

pfam13639
Location:633 → 674

zf-RING_2; Ring finger domain
NM_144859.2 → NP_659108.1 E3 ubiquitin-protein ligase Praja-2 isoform b

See identical proteins and their annotated locations for NP_659108.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an in-frame exon in the coding region, compared to variant 1. The resulting isoform (b) lacks an internal segment, compared to isoform a.

Source sequence(s)

AA067149, AK122282, BC017130, BX518494, BY065517

Consensus CDS

CCDS37674.1

UniProtKB/Swiss-Prot

Q80U04

Related

ENSMUSP00000133730.2, ENSMUST00000172733.2

Conserved Domains (1) summary

pfam13639
Location:571 → 612

zf-RING_2; Ring finger domain