Fkbp9 FK506 binding protein 9 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Fkbp9provided by MGI
Official Full Name: FK506 binding protein 9provided by MGI
Primary source: MGI:MGI:1350921
See related: Ensembl:ENSMUSG00000029781 AllianceGenome:MGI:1350921
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: FKBP-9; FKBP60; FKBP63; FKBP-63; FKBP65RS; 1810014L23
Summary: Enables calcium ion binding activity. Involved in protein folding. Located in endoplasmic reticulum. Is expressed in several structures, including central nervous system; genitourinary system; incisor; respiratory system; and skeleton. Orthologous to human FKBP9 (FKBP prolyl isomerase 9). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in limb E14.5 (RPKM 82.0), bladder adult (RPKM 56.0) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 B3; 6 27.74 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (56809044..56856345)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (56832059..56879360)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Identification and genetic mapping of the mouse Fkbp9 gene encoding a new member of FK506-binding protein family.
Title: Identification and genetic mapping of the mouse Fkbp9 gene encoding a new member of FK506-binding protein family.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA polymerase II CTD heptapeptide repeat P3 isomerase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat P6 isomerase activity	IEA Inferred from Electronic Annotation more info
enables calcium ion binding	IDA Inferred from Direct Assay more info	PubMed
enables peptidyl-prolyl cis-trans isomerase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in protein folding	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein folding	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum lumen	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: peptidyl-prolyl cis-trans isomerase FKBP9

Names: 63 kDa FK506-binding protein; 63 kDa FKBP; PPIase FKBP9; rotamase

NP_036186.2

EC 5.2.1.8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012056.2 → NP_036186.2 peptidyl-prolyl cis-trans isomerase FKBP9 precursor

See identical proteins and their annotated locations for NP_036186.2

Status: VALIDATED

Source sequence(s)

AK007499, BB794531, BC043129

Consensus CDS

CCDS39494.1

UniProtKB/Swiss-Prot

Q80ZZ6, Q8R386, Q9CVM0, Q9JHX5, Q9Z247

Related

ENSMUSP00000031795.8, ENSMUST00000031795.8

Conserved Domains (3) summary

cd00051
Location:497 → 558

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

pfam00254
Location:47 → 139

FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase

pfam13499
Location:495 → 559

EF-hand_7; EF-hand domain pair