Tas2r105 taste receptor, type 2, member 105 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tas2r105provided by MGI
Official Full Name: taste receptor, type 2, member 105provided by MGI
Primary source: MGI:MGI:2681195
See related: Ensembl:ENSMUSG00000051153 AllianceGenome:MGI:2681195
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: T2R9; T2r5; T2R05; mGR05; mt2r5; Tas2r5
Summary: Predicted to enable bitter taste receptor activity. Acts upstream of or within sensory perception of bitter taste. Predicted to be active in membrane. Is expressed in tongue anterior part. Orthologous to human TAS2R10 (taste 2 receptor member 10). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: 6 F3; 6 63.53 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (131663524..131664426, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (131686561..131687463, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The mRNA expressions of the bitter taste receptor Tas2r105 and its coupled G protein gustducin were significantly decreased with aging. However, the majority of molecules tested did not show significant expression changes.
Title: Analysis of aging-dependent changes in taste sensitivities of the senescence-accelerated mouse SAMP1.
Tas2Rs and taste-related signaling transduction cascades are also observed in mouse small intestine including duodenum, jejunum and ileum by RT-PCR and Western Blot
Title: Bitter taste receptor mTas2r105 is expressed in small intestinal villus and crypts.
Data from transgenic mice suggest that Tas2r5 is required for spermatogenesis; Tas2r5 is expressed in early to mid-stage round spermatids, but not in spermatocytes or spermatogonia. [Tas2r5; taste receptor, type 2, member 5]
Title: Depletion of bitter taste transduction leads to massive spermatid loss in transgenic mice.
The bitter taste receptors Tas2r105 and Tas2r106 are expressed in the renal corpuscle and the renal tubule, including the proximal tubule and distal tubule.
Title: Expression of bitter taste receptor Tas2r105 in mouse kidney.
Data show that brush cells of the mouse trachea express the receptors Tas2R105 and Tas2R108.
Title: Cholinergic chemosensory cells in the trachea regulate breathing.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation

General gene information

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Markers

NoName (e-PCR)
- UniSTS:493147

NoName (e-PCR)
- UniSTS:494184

NoName (e-PCR)
- UniSTS:487868

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables bitter taste receptor activity	IEA Inferred from Electronic Annotation more info
enables bitter taste receptor activity	ISO Inferred from Sequence Orthology more info
enables taste receptor activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in detection of chemical stimulus involved in sensory perception of bitter taste	IEA Inferred from Electronic Annotation more info
involved_in detection of chemical stimulus involved in sensory perception of bitter taste	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within sensory perception of bitter taste	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: taste receptor type 2 member 105

Names: T2R105; candidate taste receptor T2R5; taste receptor T2R5; taste receptor type 2 member 5; taste receptor type 2 member 9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.