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    Tgm3 transglutaminase 3, E polypeptide [ Mus musculus (house mouse) ]

    Gene ID: 21818, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Tgm3provided by MGI
    Official Full Name
    transglutaminase 3, E polypeptideprovided by MGI
    Primary source
    MGI:MGI:98732
    See related
    Ensembl:ENSMUSG00000027401 AllianceGenome:MGI:98732
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    we; TGE; TG E; TG(E); TGase E; TGase-3
    Summary
    Predicted to enable calcium ion binding activity; protein-glutamine gamma-glutamyltransferase activity; and structural molecule activity. Predicted to be involved in keratinocyte differentiation and peptide cross-linking. Located in collagen-containing extracellular matrix. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; musculoskeletal system; and nervous system. Orthologous to human TGM3 (transglutaminase 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in colon adult (RPKM 142.1), lung adult (RPKM 18.2) and 1 other tissue See more
    Orthologs
    human all
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    Genomic context

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    See Tgm3 in Genome Data Viewer
    Location:
    2 F1; 2 63.19 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (129829700..129890814)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (129987794..130050399)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_05680 Neighboring gene STARR-seq mESC enhancer starr_05681 Neighboring gene serine/threonine kinase 35, opposite strand 1 Neighboring gene STARR-seq mESC enhancer starr_05682 Neighboring gene serine/threonine kinase 35 Neighboring gene STARR-seq mESC enhancer starr_05684 Neighboring gene predicted gene, 39933 Neighboring gene STARR-seq mESC enhancer starr_05686 Neighboring gene STARR-seq mESC enhancer starr_05688 Neighboring gene predicted gene, 52561 Neighboring gene microRNA 6339 Neighboring gene predicted gene, 22424 Neighboring gene predicted gene, 24665

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. [The we gene is a modifier of the wal gene in mice]. Koniukhov BV, et al. Genetika, 2004 Jul. PMID 15458208
    2. [The mutant gene wellhaarig disturbs the differentiation of hair follicle cells in the mouse]. Koniukhov BV, et al. Ontogenez, 1990 Jan-Feb. PMID 1694022
    3. [An ultrastructural analysis of the cells of the outer root sheath of the hair follicles in mice of the wellhaarig mutant strain]. Koniukhov BV, et al. Ontogenez, 1993 Jan-Feb. PMID 8474761
    4. [Effects of the mutant gene wellhaarig in chimeric mice]. Martynova MIu, et al. Genetika, 2002 Nov. PMID 12500677
    5. Transglutaminase 3 expression in C57BL/6J mouse embryo epidermis and the correlation with its differentiation. Zhang J, et al. Cell Res, 2005 Feb. PMID 15740639

    See all (67) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Transglutaminase 3 Attenuates Skin Inflammation in Psoriasis by Inhibiting NF-kappaB Activation through Phosphorylated STAT3-TET3 Signaling.
      Title: Transglutaminase 3 Attenuates Skin Inflammation in Psoriasis by Inhibiting NF-κB Activation through Phosphorylated STAT3-TET3 Signaling.
    2. study concludes that the classic wellhaarig mutations result from defects in Tgm3
      Title: The mouse wellhaarig (we) mutations result from defects in epidermal-type transglutaminase 3 (Tgm3).
    3. Fluctuations of BMP2 signaling pathway during hair cycles in skin with mutant genes we, wal and Fgf5(go).
      Title: Fluctuations of BMP signaling pathway during hair cycles in skin of mice with mutant genes we, wal and Fgf5(go).
    4. The mutant gene we is probably responsible for a disrupted induction signal from the dermal papilla towards ectodermal cells of a hair follicle.
      Title: [Effects of the mutant gene wellhaarig in chimeric mice].
    5. Interaction of mutant genes Fgf5(go-Y), we, and wal changes the duration of hair growth cycles in mice
      Title: [Interaction of mutant genes Fgf5(go-Y), we, and wal changes the duration of hair growth cycles in mice].
    6. The first signs of alopecia in mice of the +/Fgf5(go-Y) we/wewal/wal genotype appear only three days later than in double +/+ we/wewal/wal homozygotes.
      Title: [The angora gene weakens the effect of interaction of the mutant genes wellhaarig and waved alopecia in mice].
    7. The clinically uninvolved skin in TGM3 knockout mice showed impaired barrier function and higher susceptibility to FITC sensitization indicating that TGM3 has a significant contribution to the functionally intact cutaneous barrier.
      Title: Reduced inflammatory threshold indicates skin barrier defect in transglutaminase 3 knockout mice.
    8. Loss of Tgm3 is associated with defective hair development.
      Title: Epidermal transglutaminase (TGase 3) is required for proper hair development, but not the formation of the epidermal barrier.
    9. new information on the specific distribution of TGase 3
      Title: Identification of a preferred substrate peptide for transglutaminase 3 and detection of in situ activity in skin and hair follicles.
    10. N-terminus sequence of the proteolyzed fragment was analyzed with specific antibodies.
      Title: Immunological detection of proteolytically activated epidermal-type transglutaminase (TGase 3) using cleavage-site-specific antibody.
    Submit: New GeneRIF Correction See all GeneRIFs (12)

    Phenotypes

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    Associated conditions

    Description Tests
    wellhaarig
    GeneReviews: Not available

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (1) 
    • Endonuclease-mediated (5) 
    • Gene trapped (1) 
    • Spontaneous (4)  1 citation
    • Targeted (4)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC150256, MGC150257

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables calcium ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables catalytic activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables catalytic activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables protein-glutamine gamma-glutamyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-glutamine gamma-glutamyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-glutamine gamma-glutamyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables structural molecule activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables structural molecule activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in epidermis development TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in hair cell differentiation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in keratinization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in keratinocyte differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in keratinocyte differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in peptide cross-linking ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in peptide cross-linking ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in peptide cross-linking TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in skin development TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in collagen-containing extracellular matrix HDA PubMed 
    located_in cornified envelope TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in extrinsic component of cytoplasmic side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extrinsic component of cytoplasmic side of plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of protein-containing complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    protein-glutamine gamma-glutamyltransferase E
    Names
    E polypeptide
    protein-glutamine-gamma-glutamyltransferase
    transglutaminase E
    transglutaminase-3
    NP_001408079.1
    NP_033400.2
    XP_006499214.1
    XP_011237739.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001421150.1 → NP_001408079.1  protein-glutamine gamma-glutamyltransferase E isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL808127

    2. NM_009374.4 → NP_033400.2  protein-glutamine gamma-glutamyltransferase E isoform 1 precursor

      See identical proteins and their annotated locations for NP_033400.2

      Status: VALIDATED

      Source sequence(s)
      AL808127
      Consensus CDS
      CCDS38240.1
      UniProtKB/Swiss-Prot
      A1L343, A2ANC3, Q08189
      Related
      ENSMUSP00000105928.3, ENSMUST00000110299.3
      Conserved Domains (3) summary
      smart00460
      Location:265 → 357
      TGc; Transglutaminase/protease-like homologues
      pfam00868
      Location:5 → 117
      Transglut_N; Transglutaminase family
      pfam00927
      Location:595 → 691
      Transglut_C; Transglutaminase family, C-terminal ig like domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      129829700..129890814
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011239437.3 → XP_011237739.1  protein-glutamine gamma-glutamyltransferase E isoform X2

      Conserved Domains (3) summary
      smart00460
      Location:271 → 363
      TGc; Transglutaminase/protease-like homologues
      pfam00868
      Location:10 → 124
      Transglut_N; Transglutaminase family
      pfam00927
      Location:601 → 697
      Transglut_C; Transglutaminase family, C-terminal ig like domain

    2. XM_006499151.3 → XP_006499214.1  protein-glutamine gamma-glutamyltransferase E isoform X1

      Conserved Domains (3) summary
      smart00460
      Location:276 → 368
      TGc; Transglutaminase/protease-like homologues
      pfam00868
      Location:15 → 129
      Transglut_N; Transglutaminase family
      pfam00927
      Location:606 → 702
      Transglut_C; Transglutaminase family, C-terminal ig like domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q08189.2 GenPept UniProtKB/Swiss-Prot:Q08189

    Gene LinkOut

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