Lgals9 lectin, galactose binding, soluble 9 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Lgals9provided by MGI
Official Full Name: lectin, galactose binding, soluble 9provided by MGI
Primary source: MGI:MGI:109496
See related: Ensembl:ENSMUSG00000001123 AllianceGenome:MGI:109496
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: gal-9; Lgals5; LGALS35; galectin-9
Summary: Enables several functions, including carbohydrate binding activity; galactoside binding activity; and protein serine/threonine kinase activator activity. Involved in several processes, including regulation of cytokine production; regulation of defense response; and regulation of leukocyte activation. Located in cytoplasm and nucleus. Is expressed in several structures, including cardiovascular system; hemolymphoid system; intestine; liver; and metanephros. Orthologous to several human genes including LGALS9 (galectin 9) and LGALS9B (galectin 9B). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in liver adult (RPKM 359.2), large intestine adult (RPKM 344.6) and 18 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 B5; 11 46.74 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (78853805..78875750, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (78962979..78984924, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The expression of Galectin-9 correlates with mTOR and AMPK in murine colony-forming erythroid progenitors.
Title: The expression of Galectin-9 correlates with mTOR and AMPK in murine colony-forming erythroid progenitors.
The effect of Toxoplasma gondii infection on galectin-9 expression in decidual macrophages contributing to dysfunction of decidual NK cells during pregnancy.
Title: The effect of Toxoplasma gondii infection on galectin-9 expression in decidual macrophages contributing to dysfunction of decidual NK cells during pregnancy.
SARS-Cov-2 spike induces intestinal barrier dysfunction through the interaction between CEACAM5 and Galectin-9.
Title: SARS-Cov-2 spike induces intestinal barrier dysfunction through the interaction between CEACAM5 and Galectin-9.
Galectin-9 in synergy with NF-kappaB inhibition restores immune regulatory capability in dendritic cells of subjects with food allergy.
Title: Galectin-9 in synergy with NF-κB inhibition restores immune regulatory capability in dendritic cells of subjects with food allergy.
Oncogenic miR-93-5p/Gal-9 axis drives CD8 (+) T-cell inactivation and is a therapeutic target for hepatocellular carcinoma immunotherapy.
Title: Oncogenic miR-93-5p/Gal-9 axis drives CD8 (+) T-cell inactivation and is a therapeutic target for hepatocellular carcinoma immunotherapy.
Mesenchymal stem cells protect against sepsis-associated acute kidney injury by inducing Gal-9/Tim-3 to remodel immune homeostasis.
Title: Mesenchymal stem cells protect against sepsis-associated acute kidney injury by inducing Gal-9/Tim-3 to remodel immune homeostasis.
Tim-3/Galectin-9 signaling pathway is involved in the cytokine changes in mice with alveolar echinococcosis.
Title: Tim-3/Galectin-9 signaling pathway is involved in the cytokine changes in mice with alveolar echinococcosis.
Obesity-induced galectin-9 is a therapeutic target in B-cell acute lymphoblastic leukemia.
Title: Obesity-induced galectin-9 is a therapeutic target in B-cell acute lymphoblastic leukemia.
Lgals9 deficiency ameliorates obesity by modulating redox state of PRDX2.
Title: Lgals9 deficiency ameliorates obesity by modulating redox state of PRDX2.
Serial transplantation unmasks galectin-9 contribution to tumor immune escape in the MB49 murine model.
Title: Serial transplantation unmasks galectin-9 contribution to tumor immune escape in the MB49 murine model.

Submit: New GeneRIF Correction See all GeneRIFs (75)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (7)
Gene trapped (1)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI194909 (e-PCR)
- UniSTS:185900

D11Bhm83 (e-PCR), detects polymorphism
- UniSTS:141690

D11Bhm84 (e-PCR), detects polymorphism
- UniSTS:141691

D11Bhm85 (e-PCR), detects polymorphism
- UniSTS:141692

AI265545 (e-PCR)
- UniSTS:160129

RH125675 (e-PCR)
- UniSTS:162456

Lgals9 (e-PCR), detects polymorphism
- UniSTS:519413

Lgals9 (e-PCR), detects polymorphism
- UniSTS:519414

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables carbohydrate binding	IBA Inferred from Biological aspect of Ancestor more info
enables carbohydrate binding	IDA Inferred from Direct Assay more info	PubMed
enables carbohydrate binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables carbohydrate binding	ISO Inferred from Sequence Orthology more info
enables carbohydrate binding	ISS Inferred from Sequence or Structural Similarity more info
enables disaccharide binding	ISO Inferred from Sequence Orthology more info
enables enzyme binding	IPI Inferred from Physical Interaction more info	PubMed
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables galactoside binding	IBA Inferred from Biological aspect of Ancestor more info
enables galactoside binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables galactoside binding	ISA Inferred from Sequence Alignment more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein serine/threonine kinase activator activity	IDA Inferred from Direct Assay more info	PubMed
enables signaling receptor binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular response to virus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chemotaxis	IEA Inferred from Electronic Annotation more info
involved_in female pregnancy	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	ISA Inferred from Sequence Alignment more info	PubMed
involved_in immune system process	IEA Inferred from Electronic Annotation more info
involved_in maintenance of protein location	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of CD4-positive, alpha-beta T cell proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of CD4-positive, alpha-beta T cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of natural killer cell activation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of natural killer cell degranulation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of type II interferon production	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of type II interferon production	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of type II interferon production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of SMAD protein signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of T cell migration	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of chemokine production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cysteine-type endopeptidase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytokine production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of defense response to bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of gene expression	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of innate immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of interleukin-1 production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of interleukin-10 production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of interleukin-6 production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of macrophage activation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of oxidoreductase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of regulatory T cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of tumor necrosis factor production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in receptor clustering	IDA Inferred from Direct Assay more info	PubMed
NOT involved_in regulation of T cell chemotaxis	IDA Inferred from Direct Assay more info	PubMed
NOT involved_in regulation of T cell differentiation in thymus	IMP Inferred from Mutant Phenotype more info	PubMed
NOT involved_in regulation of T-helper 17 type immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of natural killer cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to lipopolysaccharide	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transforming growth factor beta receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in collagen-containing extracellular matrix	HDA more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in extracellular region	TAS Traceable Author Statement more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: galectin-9

Names: lectin, galactose binding, soluble 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001159301.1 → NP_001152773.1 galectin-9 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1. This difference results in a shorter isoform (2), compared to isoform 1.

Source sequence(s)

AK146044, CA546274

Consensus CDS

CCDS48858.1

UniProtKB/TrEMBL

B1AQR8

Related

ENSMUSP00000103903.4, ENSMUST00000108268.10

Conserved Domains (2) summary

smart00908
Location:199 → 321

Gal-bind_lectin; Galactoside-binding lectin

cd00070
Location:16 → 145

GLECT; Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as lactose, and does not require metal ions for activity. GLECT domains occur as homodimers or tandemly repeated domains. They are developmentally regulated and may ...
NM_010708.2 → NP_034838.2 galectin-9 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AK146044, CA458877, CA546274

Consensus CDS

CCDS25116.1

UniProtKB/Swiss-Prot

O08572, O08573, Q3UKE5, Q99L83

UniProtKB/TrEMBL

B1AQR8, G3X9T7

Related

ENSMUSP00000103904.4, ENSMUST00000108269.10

Conserved Domains (2) summary

smart00908
Location:230 → 352

Gal-bind_lectin; Galactoside-binding lectin

cd00070
Location:16 → 145

GLECT; Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as lactose, and does not require metal ions for activity. GLECT domains occur as homodimers or tandemly repeated domains. They are developmentally regulated and may ...