Chad chondroadherin [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Chadprovided by MGI
Official Full Name: chondroadherinprovided by MGI
Primary source: MGI:MGI:1096866
See related: Ensembl:ENSMUSG00000039084 AllianceGenome:MGI:1096866
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: SLRR4A
Summary: Acts upstream of or within bone development and negative regulation of bone trabecula formation. Predicted to be located in extracellular region. Predicted to be active in extracellular matrix and extracellular space. Is expressed in several structures, including cartilage; sensory organ; skeleton; trachea cartilaginous ring; and ventral body wall. Orthologous to human CHAD (chondroadherin). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in duodenum adult (RPKM 16.9), lung adult (RPKM 15.9) and 9 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 D; 11 58.9 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (94455873..94459953)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (94565047..94569127)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Chondroadherin likely affects cartilage modulus by regulating collagen network.
Title: Nanomechanical phenotype of chondroadherin-null murine articular cartilage.
The skeletal phenotype points at a role for chondroadherin in both bone and cartilage homeostasis, however, without leading to altered longitudinal growth.
Title: The skeletal phenotype of chondroadherin deficient mice.
number of cells adhering via their beta(1) integrin receptor to collagen type II or chondroadherin was profoundly and rapidly enhanced by the addition of the heparin-binding peptide
Title: The C-terminal peptide of chondroadherin modulates cellular activity by selectively binding to heparan sulfate chains.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation

General gene information

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Markers

Chad (e-PCR), detects polymorphism
- UniSTS:141330

D11Mit288 (e-PCR), detects polymorphism
- UniSTS:126495

D11Dcr17 (e-PCR), detects polymorphism
- UniSTS:507460

U96626 (e-PCR)
- UniSTS:160143

Gene Ontology Provided by MGI

Process	Evidence Code	Pubs
acts_upstream_of_or_within bone development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of bone trabecula formation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: chondroadherin

Names: cartilage leucine-rich protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_007689.5 → NP_031715.1 chondroadherin precursor

See identical proteins and their annotated locations for NP_031715.1

Status: VALIDATED

Source sequence(s)

AK158297, AL645809, BQ175638

Consensus CDS

CCDS25260.1

UniProtKB/Swiss-Prot

O55226

UniProtKB/TrEMBL

Q3TYW1

Related

ENSMUSP00000047844.9, ENSMUST00000040418.9

Conserved Domains (5) summary

smart00082
Location:299 → 346

LRRCT; Leucine rich repeat C-terminal domain

cd00116
Location:89 → 281

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00033
Location:52 → 75

LRR_RI; leucine-rich repeat [structural motif]

pfam01462
Location:22 → 48

LRRNT; Leucine rich repeat N-terminal domain

pfam13855
Location:74 → 134

LRR_8; Leucine rich repeat