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    Zfp354a zinc finger protein 354A [ Mus musculus (house mouse) ]

    Gene ID: 21408, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Zfp354aprovided by MGI
    Official Full Name
    zinc finger protein 354Aprovided by MGI
    Primary source
    MGI:MGI:103172
    See related
    Ensembl:ENSMUSG00000020364 AllianceGenome:MGI:103172
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    kid1; Tcf17; Znf354a
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II and nucleolus organization. Predicted to be located in cytosol; nucleolus; and nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and liver and biliary system. Orthologous to human ZNF354A (zinc finger protein 354A). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in CNS E18 (RPKM 2.5), CNS E14 (RPKM 2.0) and 22 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zfp354a in Genome Data Viewer
    Location:
    11 B1.3; 11 30.97 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (50950052..50963626)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (51059225..51072799)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_29410 Neighboring gene olfactory receptor family 1 subfamily X member 2 Neighboring gene olfactory receptor family 1 subfamily X member 6 Neighboring gene RIKEN cDNA 9230009I02 gene Neighboring gene tubulin alpha-4 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The transcription factor, Kid-1, is highly expressed in both eye and kidney of the mouse. Brady JP, et al. Exp Eye Res, 1997 Feb. PMID 9176064
    2. Molecular cloning of a zinc finger gene eZNF from a human inner ear cDNA library, and in situ expression pattern of its mouse homologue in mouse inner ear. Jacob AN, et al. Somat Cell Mol Genet, 1998 Mar. PMID 9919311
    3. Characterization of the mouse Kid1 gene and identification of a highly related gene, Kid2. Tekki-Kessaris N, et al. Gene, 1999 Nov 15. PMID 10564808
    4. Analysis of the organization and nucleotide sequence of the chromosomal gene for the beta-subunit of rat thyrotropin. Croyle ML, et al. DNA, 1986 Aug. PMID 3017658
    5. A novel member of the RING finger family, KRIP-1, associates with the KRAB-A transcriptional repressor domain of zinc finger proteins. Kim SS, et al. Proc Natl Acad Sci U S A, 1996 Dec 24. PMID 8986806, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC91222

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nucleolus organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 354A
    Names
    kidney, ischemia, and developmentally-regulated protein 1
    renal transcription factor Kid-1
    transcription factor 17

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001326566.2 → NP_001313495.1  zinc finger protein 354A isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, uses an alternate start codon and uses an alternate in-frame splice site in the 5' coding region, compared to variant 3. It encodes isoform 2, which is shorter and has a distinct N-terminus, compared to isoform 3.
      Source sequence(s)
      AL645962
      Consensus CDS
      CCDS83802.1
      UniProtKB/TrEMBL
      Q5PPR4
      Related
      ENSMUSP00000104750.2, ENSMUST00000109122.8
      Conserved Domains (5) summary
      smart00349
      Location:13 → 72
      KRAB; krueppel associated box
      COG5048
      Location:209 → 566
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:462 → 482
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:13 → 52
      KRAB; KRAB box
      pfam13465
      Location:334 → 359
      zf-H2C2_2; Zinc-finger double domain

    2. NM_001347495.2 → NP_001334424.1  zinc finger protein 354A isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) encodes the longest isoform (3).
      Source sequence(s)
      AL645962
      Consensus CDS
      CCDS83803.1
      UniProtKB/TrEMBL
      B1ATG3
      Related
      ENSMUSP00000104747.2, ENSMUST00000109119.8
      Conserved Domains (4) summary
      smart00349
      Location:14 → 74
      KRAB; krueppel associated box
      COG5048
      Location:211 → 568
      COG5048; FOG: Zn-finger [General function prediction only]
      COG5189
      Location:128 → 264
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:464 → 484
      ZF_C2H2; C2H2 Zn finger [structural motif]

    3. NM_009329.5 → NP_033355.2  zinc finger protein 354A isoform 1

      See identical proteins and their annotated locations for NP_033355.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR and uses an alternate in-frame splice site in the 5' coding region, compared to variant 3. It encodes isoform 1, which is shorter than isoform 3.
      Source sequence(s)
      AL645962
      Consensus CDS
      CCDS24648.1
      UniProtKB/Swiss-Prot
      Q61751, Q9QXU0
      Related
      ENSMUSP00000099827.4, ENSMUST00000102766.10
      Conserved Domains (3) summary
      smart00349
      Location:14 → 73
      KRAB; krueppel associated box
      COG5048
      Location:184 → 567
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:463 → 483
      ZF_C2H2; C2H2 Zn finger [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      50950052..50963626
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036156508.1 → XP_036012401.1  zinc finger protein 354A isoform X4

      Conserved Domains (2) summary
      COG5048
      Location:76 → 459
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:355 → 375
      ZF_C2H2; C2H2 Zn finger [structural motif]

    2. XM_006532790.1 → XP_006532853.1  zinc finger protein 354A isoform X2

      See identical proteins and their annotated locations for XP_006532853.1

      UniProtKB/Swiss-Prot
      Q61751, Q9QXU0
      Conserved Domains (3) summary
      smart00349
      Location:14 → 73
      KRAB; krueppel associated box
      COG5048
      Location:184 → 567
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:463 → 483
      ZF_C2H2; C2H2 Zn finger [structural motif]

    3. XM_011248885.1 → XP_011247187.1  zinc finger protein 354A isoform X3

      See identical proteins and their annotated locations for XP_011247187.1

      Conserved Domains (4) summary
      smart00349
      Location:13 → 73
      KRAB; krueppel associated box
      COG5048
      Location:210 → 567
      COG5048; FOG: Zn-finger [General function prediction only]
      COG5189
      Location:127 → 263
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:463 → 483
      ZF_C2H2; C2H2 Zn finger [structural motif]

    4. XM_036156506.1 → XP_036012399.1  zinc finger protein 354A isoform X2

      UniProtKB/Swiss-Prot
      Q61751, Q9QXU0
      Related
      ENSMUSP00000020628.6, ENSMUST00000020628.6
      Conserved Domains (3) summary
      smart00349
      Location:14 → 73
      KRAB; krueppel associated box
      COG5048
      Location:184 → 567
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:463 → 483
      ZF_C2H2; C2H2 Zn finger [structural motif]

    5. XM_011248886.1 → XP_011247188.1  zinc finger protein 354A isoform X3

      See identical proteins and their annotated locations for XP_011247188.1

      Conserved Domains (4) summary
      smart00349
      Location:13 → 73
      KRAB; krueppel associated box
      COG5048
      Location:210 → 567
      COG5048; FOG: Zn-finger [General function prediction only]
      COG5189
      Location:127 → 263
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:463 → 483
      ZF_C2H2; C2H2 Zn finger [structural motif]

    6. XM_036156507.1 → XP_036012400.1  zinc finger protein 354A isoform X4

      Conserved Domains (2) summary
      COG5048
      Location:76 → 459
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:355 → 375
      ZF_C2H2; C2H2 Zn finger [structural motif]

    7. XM_006532789.1 → XP_006532852.1  zinc finger protein 354A isoform X1

      See identical proteins and their annotated locations for XP_006532852.1

      UniProtKB/TrEMBL
      B1ATG3
      Conserved Domains (4) summary
      smart00349
      Location:14 → 74
      KRAB; krueppel associated box
      COG5048
      Location:211 → 568
      COG5048; FOG: Zn-finger [General function prediction only]
      COG5189
      Location:128 → 264
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:464 → 484
      ZF_C2H2; C2H2 Zn finger [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q61751.2 GenPept UniProtKB/Swiss-Prot:Q61751

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