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    Asb12 ankyrin repeat and SOCS box-containing 12 [ Mus musculus (house mouse) ]

    Gene ID: 70392, updated on 9-Dec-2024

    Summary

    Official Symbol
    Asb12provided by MGI
    Official Full Name
    ankyrin repeat and SOCS box-containing 12provided by MGI
    Primary source
    MGI:MGI:1917642
    See related
    Ensembl:ENSMUSG00000031204 AllianceGenome:MGI:1917642
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Asb-12; 2310036C05Rik
    Summary
    Predicted to contribute to ubiquitin protein ligase activity. Predicted to be involved in protein ubiquitination. Predicted to be part of ubiquitin ligase complex. Orthologous to human ASB12 (ankyrin repeat and SOCS box containing 12). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in testis adult (RPKM 3.3), heart adult (RPKM 3.0) and 4 other tissues See more
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    Genomic context

    See Asb12 in Genome Data Viewer
    Location:
    X C3; X 41.99 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (94513125..94601610, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (95469527..95558004, complement)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene APC membrane recruitment 1 Neighboring gene ring finger and WD repeat domain 2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_47573 Neighboring gene STARR-seq mESC enhancer starr_47574 Neighboring gene zinc finger, C4H2 domain containing Neighboring gene adenylosuccinate lyase pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC130200

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    contributes_to ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ubiquitin protein ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    contributes_to ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of ubiquitin ligase complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    ankyrin repeat and SOCS box protein 12
    Names
    ankyrin repeat and SOCS box-containing protein 12
    ankyrin repeat domain-containing SOCS box protein 12

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001313743.1NP_001300672.1  ankyrin repeat and SOCS box protein 12

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants encode the same protein.
      Source sequence(s)
      AL671765, BC107257
      Consensus CDS
      CCDS30283.1
      UniProtKB/Swiss-Prot
      Q9D738
      UniProtKB/TrEMBL
      Q3KNI9
      Conserved Domains (4) summary
      PHA02875
      Location:25259
      PHA02875; ankyrin repeat protein; Provisional
      sd00045
      Location:6694
      ANK; ANK repeat [structural motif]
      pfam07525
      Location:268306
      SOCS_box; SOCS box
      pfam12796
      Location:68159
      Ank_2; Ankyrin repeats (3 copies)
    2. NM_080858.3NP_543134.1  ankyrin repeat and SOCS box protein 12

      See identical proteins and their annotated locations for NP_543134.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants encode the same protein.
      Source sequence(s)
      AL671765
      Consensus CDS
      CCDS30283.1
      UniProtKB/Swiss-Prot
      Q9D738
      UniProtKB/TrEMBL
      Q3KNI9
      Related
      ENSMUSP00000033549.3, ENSMUST00000033549.3
      Conserved Domains (4) summary
      PHA02875
      Location:25259
      PHA02875; ankyrin repeat protein; Provisional
      sd00045
      Location:6694
      ANK; ANK repeat [structural motif]
      pfam07525
      Location:268306
      SOCS_box; SOCS box
      pfam12796
      Location:68159
      Ank_2; Ankyrin repeats (3 copies)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      94513125..94601610 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011247674.4XP_011245976.1  ankyrin repeat and SOCS box protein 12 isoform X1

      See identical proteins and their annotated locations for XP_011245976.1

      UniProtKB/Swiss-Prot
      Q9D738
      UniProtKB/TrEMBL
      Q3KNI9
      Conserved Domains (4) summary
      PHA02875
      Location:25259
      PHA02875; ankyrin repeat protein; Provisional
      sd00045
      Location:6694
      ANK; ANK repeat [structural motif]
      pfam07525
      Location:268306
      SOCS_box; SOCS box
      pfam12796
      Location:68159
      Ank_2; Ankyrin repeats (3 copies)