Usp7 ubiquitin specific peptidase 7 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Usp7provided by MGI
Official Full Name: ubiquitin specific peptidase 7provided by MGI
Primary source: MGI:MGI:2182061
See related: Ensembl:ENSMUSG00000022710 AllianceGenome:MGI:2182061
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Hausp; 2210010O09Rik
Summary: Enables cysteine-type deubiquitinase activity and cysteine-type endopeptidase activity. Involved in several processes, including protein deubiquitination; regulation of protein stability; and transcription elongation-coupled chromatin remodeling. Located in XY body; cytoplasm; and nucleus. Is expressed in blastocyst; embryo; inner cell mass; and trophectoderm. Orthologous to human USP7 (ubiquitin specific peptidase 7). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 25.2), liver E14 (RPKM 24.8) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 16 A1; 16 4.28 cM

Exon count:: 34

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	16	NC_000082.7 (8506586..8574931, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	16	NC_000082.6 (8688722..8757067, complement)

Chromosome 16 - NC_000082.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

USP7 promotes IgA class switching through stabilizing RUNX3 for germline transcription activation.
Title: USP7 promotes IgA class switching through stabilizing RUNX3 for germline transcription activation.
USP7 Promotes TGF-beta1 Signaling by De-Ubiquitinating Smad2/Smad3 in Pulmonary Fibrosis.
Title: USP7 Promotes TGF-β1 Signaling by De-Ubiquitinating Smad2/Smad3 in Pulmonary Fibrosis.
USP7 promotes cardiometabolic disorders and mitochondrial homeostasis dysfunction in diabetic mice via stabilizing PGC1beta.
Title: USP7 promotes cardiometabolic disorders and mitochondrial homeostasis dysfunction in diabetic mice via stabilizing PGC1β.
USP7 cardiomyocyte specific knockout causes disordered mitochondrial biogenesis and dynamics and early neonatal lethality in mice.
Title: USP7 cardiomyocyte specific knockout causes disordered mitochondrial biogenesis and dynamics and early neonatal lethality in mice.
DNA polymerase iota promotes EMT and metastasis of esophageal squamous cell carcinoma by interacting with USP7 to stabilize HIF-1alpha.
Title: DNA polymerase iota promotes EMT and metastasis of esophageal squamous cell carcinoma by interacting with USP7 to stabilize HIF-1α.
Extracellular vesicles from bone marrow mesenchymal stem cells alleviate osteoporosis in mice through USP7-mediated YAP1 protein stability and the Wnt/beta-catenin pathway.
Title: Extracellular vesicles from bone marrow mesenchymal stem cells alleviate osteoporosis in mice through USP7-mediated YAP1 protein stability and the Wnt/β-catenin pathway.
USP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and noncatalytic activities.
Title: USP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and noncatalytic activities.
USP7 reduction leads to developmental failure of mouse early embryos.
Title: USP7 reduction leads to developmental failure of mouse early embryos.
USP7 controls NGN3 stability and pancreatic endocrine lineage development.
Title: USP7 controls NGN3 stability and pancreatic endocrine lineage development.
Organ defects of the Usp7[K444R] mutant mouse strain indicate the essential role of K63-polyubiquitinated Usp7 in organ formation.
Title: Organ defects of the Usp7(K444R) mutant mouse strain indicate the essential role of K63-polyubiquitinated Usp7 in organ formation.

Submit: New GeneRIF Correction See all GeneRIFs (39)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (6)
Gene trapped (1)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH126966 (e-PCR)
- UniSTS:209161

RH136474 (e-PCR)
- UniSTS:210459

RH124261 (e-PCR)
- UniSTS:161083

RH125901 (e-PCR)
- UniSTS:162625

NoName (e-PCR)
- UniSTS:237424

NoName (e-PCR)
- UniSTS:237425

AW548146 (e-PCR)
- UniSTS:180860

RH140275 (e-PCR)
- UniSTS:222353

RH65300 (e-PCR)
- UniSTS:48073

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables K48-linked deubiquitinase activity	ISO Inferred from Sequence Orthology more info
enables K48-linked deubiquitinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables cysteine-type deubiquitinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables cysteine-type deubiquitinase activity	IDA Inferred from Direct Assay more info	PubMed
enables cysteine-type deubiquitinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables cysteine-type deubiquitinase activity	ISO Inferred from Sequence Orthology more info	PubMed
enables cysteine-type deubiquitinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables cysteine-type endopeptidase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables cysteine-type endopeptidase activity	ISO Inferred from Sequence Orthology more info
enables deubiquitinase activity	ISO Inferred from Sequence Orthology more info
enables deubiquitinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables p53 binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA alkylation repair	ISO Inferred from Sequence Orthology more info
involved_in DNA alkylation repair	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within monoubiquitinated protein deubiquitination	ISO Inferred from Sequence Orthology more info	PubMed
involved_in negative regulation of NF-kappaB transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of TORC1 signaling	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of gene expression via chromosomal CpG island methylation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of gluconeogenesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of gluconeogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in protein deubiquitination	IDA Inferred from Direct Assay more info	PubMed
involved_in protein deubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein deubiquitination	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein stabilization	ISO Inferred from Sequence Orthology more info
involved_in protein stabilization	ISS Inferred from Sequence or Structural Similarity more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
involved_in regulation of DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-binding transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of circadian rhythm	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of circadian rhythm	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein stability	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of protein stability	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of protein stability	ISO Inferred from Sequence Orthology more info
involved_in regulation of retrograde transport, endosome to Golgi	ISO Inferred from Sequence Orthology more info
involved_in rhythmic process	IEA Inferred from Electronic Annotation more info
involved_in symbiont-mediated disruption of host cell PML body	ISO Inferred from Sequence Orthology more info
involved_in transcription elongation-coupled chromatin remodeling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transcription-coupled nucleotide-excision repair	ISO Inferred from Sequence Orthology more info
involved_in transcription-coupled nucleotide-excision repair	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in PML body	IEA Inferred from Electronic Annotation more info
is_active_in PML body	ISO Inferred from Sequence Orthology more info
located_in XY body	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ubiquitin carboxyl-terminal hydrolase 7

Names: deubiquitinating enzyme 7; herpesvirus-associated ubiquitin-specific protease; mHAUSP; ubiquitin specific protease 7; ubiquitin thioesterase 7; ubiquitin thiolesterase 7; ubiquitin-specific-processing protease 7

NP_001003918.2

EC 3.4.19.12

XP_006522201.1

EC 3.4.19.12

XP_006522202.1

EC 3.4.19.12

XP_006522204.1

EC 3.4.19.12

XP_030104976.1

EC 3.4.19.12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001003918.2 → NP_001003918.2 ubiquitin carboxyl-terminal hydrolase 7

See identical proteins and their annotated locations for NP_001003918.2

Status: VALIDATED

Source sequence(s)

AC115005, AC156026, AF548565, AK135814

Consensus CDS

CCDS49755.1

UniProtKB/Swiss-Prot

Q3UX92, Q496Y5, Q6A4J8, Q8BW01

UniProtKB/TrEMBL

F8VPX1

Related

ENSMUSP00000124093.3, ENSMUST00000161046.9

Conserved Domains (5) summary

COG5077
Location:56 → 1101

COG5077; Ubiquitin carboxyl-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]

cd02659
Location:213 → 524

peptidase_C19C; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

cd03772
Location:68 → 203

MATH_HAUSP; Herpesvirus-associated ubiquitin-specific protease (HAUSP, also known as USP7) family, N-terminal MATH (TRAF-like) domain; composed of proteins similar to human HAUSP, an enzyme that specifically catalyzes the deubiquitylation of p53 and MDM2, hence ...

pfam12436
Location:621 → 866

USP7_ICP0_bdg; ICP0-binding domain of Ubiquitin-specific protease 7

pfam14533
Location:876 → 1087

USP7_C2; Ubiquitin-specific protease C-terminal

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000082.7 Reference GRCm39 C57BL/6J

Range

8506586..8574931 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006522138.4 → XP_006522201.1 ubiquitin carboxyl-terminal hydrolase 7 isoform X1

UniProtKB/Swiss-Prot

Q3UX92, Q496Y5, Q6A4J8, Q8BW01

UniProtKB/TrEMBL

E9PXY8

Related

ENSMUSP00000124382.2, ENSMUST00000160405.8

Conserved Domains (1) summary

COG5077
Location:96 → 1141

COG5077; Ubiquitin carboxyl-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
XM_006522141.4 → XP_006522204.1 ubiquitin carboxyl-terminal hydrolase 7 isoform X3

UniProtKB/Swiss-Prot

Q3UX92, Q496Y5, Q6A4J8, Q8BW01

Conserved Domains (1) summary

COG5077
Location:6 → 1001

COG5077; Ubiquitin carboxyl-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
XM_030249116.2 → XP_030104976.1 ubiquitin carboxyl-terminal hydrolase 7 isoform X3

UniProtKB/Swiss-Prot

Q3UX92, Q496Y5, Q6A4J8, Q8BW01

Conserved Domains (1) summary

COG5077
Location:6 → 1001

COG5077; Ubiquitin carboxyl-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
XM_006522139.4 → XP_006522202.1 ubiquitin carboxyl-terminal hydrolase 7 isoform X2

UniProtKB/Swiss-Prot

Q3UX92, Q496Y5, Q6A4J8, Q8BW01

Conserved Domains (1) summary

COG5077
Location:39 → 1084

COG5077; Ubiquitin carboxyl-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]