Trim11 tripartite motif-containing 11 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Trim11provided by MGI
Official Full Name: tripartite motif-containing 11provided by MGI
Primary source: MGI:MGI:2137355
See related: Ensembl:ENSMUSG00000020455 AllianceGenome:MGI:2137355
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Enables protein domain specific binding activity and ubiquitin protein ligase activity. Involved in several processes, including defense response to symbiont; negative regulation of viral transcription; and regulation of viral entry into host cell. Located in cytoplasm and nucleus. Is expressed in several structures, including gut; hemolymphoid system gland; nervous system; submandibular gland primordium; and urinary system. Orthologous to human TRIM11 (tripartite motif containing 11). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in thymus adult (RPKM 23.0), spleen adult (RPKM 15.4) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 B1.3; 11 36.4 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (58865054..58882288)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (58973726..58991462)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TRIM11 expression levels was downregulated and prevents ferroptosis of cardiomyocyte by Dusp6 in acute myocardial infarction.
Title: TRIM11 expression levels was downregulated and prevents ferroptosis of cardiomyocyte by Dusp6 in acute myocardial infarction.
TRIM11 attenuates Treg cell differentiation by p62-selective autophagic degradation of AIM2.
Title: TRIM11 attenuates Treg cell differentiation by p62-selective autophagic degradation of AIM2.
TRIM11 suppresses AIM2 inflammasome by degrading AIM2 via p62-dependent selective autophagy.
Title: TRIM11 Suppresses AIM2 Inflammasome by Degrading AIM2 via p62-Dependent Selective Autophagy.
The results suggest that TRIM11 plays a role in the regulation of intracellular humanin level through ubiquitin-mediated protein degradation pathways.
Title: A tripartite motif protein TRIM11 binds and destabilizes Humanin, a neuroprotective peptide against Alzheimer's disease-relevant insults.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-macromolecule adaptor activity	ISO Inferred from Sequence Orthology more info
enables protein-macromolecule adaptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase activity	IDA Inferred from Direct Assay more info	PubMed
enables ubiquitin-protein transferase activity	IDA Inferred from Direct Assay more info	PubMed
enables ubiquitin-protein transferase activity	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in innate immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in innate immune response	IDA Inferred from Direct Assay more info	PubMed
involved_in innate immune response	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of AIM2 inflammasome complex assembly	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of AIM2 inflammasome complex assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of neurogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of viral entry into host cell	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of viral entry into host cell	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of viral entry into host cell	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of viral transcription	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of viral transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of viral transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of viral entry into host cell	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of viral entry into host cell	ISO Inferred from Sequence Orthology more info
involved_in protein autoubiquitination	IEA Inferred from Electronic Annotation more info
involved_in protein autoubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in regulation of gene expression	IBA Inferred from Biological aspect of Ancestor more info
involved_in suppression of viral release by host	IBA Inferred from Biological aspect of Ancestor more info
involved_in suppression of viral release by host	IDA Inferred from Direct Assay more info	PubMed
involved_in suppression of viral release by host	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: E3 ubiquitin-protein ligase TRIM11

Names: RING-type E3 ubiquitin transferase TRIM11; tripartite motif-containing protein 11

NP_001277917.1

EC 2.3.2.27

NP_444398.1

EC 2.3.2.27

XP_006534642.1

EC 2.3.2.27

XP_011247637.1

EC 2.3.2.27

XP_030102306.1

EC 2.3.2.27

XP_036013004.1

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001290988.1 → NP_001277917.1 E3 ubiquitin-protein ligase TRIM11 isoform 1

See identical proteins and their annotated locations for NP_001277917.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AK040618, AK139477, AL662809

Consensus CDS

CCDS70195.1

UniProtKB/Swiss-Prot

Q99PQ2

Related

ENSMUSP00000104438.4, ENSMUST00000108810.10

Conserved Domains (3) summary

pfam00643
Location:87 → 127

zf-B_box; B-box zinc finger

pfam15227
Location:16 → 56

zf-C3HC4_4; zinc finger of C3HC4-type, RING

cl02614
Location:303 → 471

SPRY; SPRY domain
NM_053168.2 → NP_444398.1 E3 ubiquitin-protein ligase TRIM11 isoform 2

See identical proteins and their annotated locations for NP_444398.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an in-frame exon, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.

Source sequence(s)

AK040618, AK139477, AL662809

Consensus CDS

CCDS36168.1

UniProtKB/Swiss-Prot

A2A868, A2AB84, Q3TCL5, Q8VDX5, Q99PQ2

Related

ENSMUSP00000090749.7, ENSMUST00000093061.7

Conserved Domains (3) summary

pfam00643
Location:87 → 127

zf-B_box; B-box zinc finger

pfam15227
Location:16 → 56

zf-C3HC4_4; zinc finger of C3HC4-type, RING

cl02614
Location:287 → 455

SPRY; SPRY domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

58865054..58882288

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036157111.1 → XP_036013004.1 E3 ubiquitin-protein ligase TRIM11 isoform X1

Conserved Domains (4) summary

COG1196
Location:132 → 234

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd00162
Location:16 → 56

RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]

cl00034
Location:90 → 131

Bbox_SF; B-box-type zinc finger superfamily

cl17238
Location:13 → 57

RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
XM_006534579.4 → XP_006534642.1 E3 ubiquitin-protein ligase TRIM11 isoform X3

UniProtKB/TrEMBL

A2AB83

Conserved Domains (4) summary

COG1196
Location:132 → 234

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd00162
Location:16 → 56

RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]

cl00034
Location:90 → 131

Bbox_SF; B-box-type zinc finger superfamily

cl17238
Location:13 → 57

RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
XM_030246446.2 → XP_030102306.1 E3 ubiquitin-protein ligase TRIM11 isoform X2

Conserved Domains (1) summary

cl02614
Location:135 → 303

SPRY; SPRY domain
XM_011249335.4 → XP_011247637.1 E3 ubiquitin-protein ligase TRIM11 isoform X4

Conserved Domains (1) summary

cl02614
Location:62 → 230

SPRY; SPRY domain