Il10rb interleukin 10 receptor, beta [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Il10rbprovided by MGI
Official Full Name: interleukin 10 receptor, betaprovided by MGI
Primary source: MGI:MGI:109380
See related: Ensembl:ENSMUSG00000022969 AllianceGenome:MGI:109380
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Crfb4; CRF2-4; Il10r2; D21S58h; IL-10R2; D16H21S58; 6620401D04Rik
Summary: Enables interleukin-10 receptor activity. Predicted to be involved in interleukin-10-mediated signaling pathway; positive regulation of cellular respiration; and positive regulation of receptor signaling pathway via JAK-STAT. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in graft-versus-host disease; hepatitis B; and inflammatory bowel disease 25. Orthologous to human IL10RB (interleukin 10 receptor subunit beta). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in adrenal adult (RPKM 39.0), heart adult (RPKM 34.7) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 16 C3.3; 16 52.87 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	16	NC_000082.7 (91203166..91222718)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	16	NC_000082.6 (91406157..91425834)

Chromosome 16 - NC_000082.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Modulation of IL10 and Its Receptor Subunits in Normal and Progesterone-Prolonged Gestation in the Mouse.
Title: Modulation of IL10 and Its Receptor Subunits in Normal and Progesterone-Prolonged Gestation in the Mouse.
Blocking IL-10 receptor signaling ameliorates Mycobacterium tuberculosis infection during influenza-induced exacerbation.
Title: Blocking IL-10 receptor signaling ameliorates Mycobacterium tuberculosis infection during influenza-induced exacerbation.
The investigation of the IL-10R complex revealed that both the extracellular and intracellular domains of IL-10R2 influence the conformation of IL-10R1 and that both domains were required for transducing IL-10 signals.
Title: Re-evaluation of IL-10 signaling reveals novel insights on the contribution of the intracellular domain of the IL-10R2 chain.
evaluation of the ability of specific fatty acids to modulate production of the proinflammatory cytokine, tumor necrosis factor-alpha (TNF-alpha), and the anti-inflammatory cytokine, interleukin-10 (IL-10), in murine 3T3-L1 adipocytes
Title: Dietary fatty acids differentially regulate production of TNF-alpha and IL-10 by murine 3T3-L1 adipocytes.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (2) 1 citation

General gene information

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Markers

Il10rb (e-PCR), detects polymorphism
- UniSTS:259094

NoName (e-PCR)
- UniSTS:492569

Il10rb (e-PCR), detects polymorphism
- UniSTS:259622

AI747302 (e-PCR)
- UniSTS:160592

AI528744 (e-PCR)
- UniSTS:180944

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables coreceptor activity	ISO Inferred from Sequence Orthology more info
enables interleukin-10 receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables interleukin-10 receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cytokine-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cytokine-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in defense response to virus	IEA Inferred from Electronic Annotation more info
involved_in interleukin-10-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cellular respiration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of receptor signaling pathway via JAK-STAT	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: interleukin-10 receptor subunit beta

Names: IL-10 receptor subunit beta; IL-10R subunit 2; IL-10R subunit beta; IL-10RB; cytokine receptor class-II member 4; cytokine receptor family 2 member 4; cytokine receptor family II, member 4; interleukin 10 receptor 2; interleukin-10 receptor subunit 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001405058.1 → NP_001391987.1 interleukin-10 receptor subunit beta isoform 2

Status: VALIDATED

Source sequence(s)

AC152503

UniProtKB/TrEMBL

Q3TU35
NM_001405059.1 → NP_001391988.1 interleukin-10 receptor subunit beta isoform 3 precursor

Status: VALIDATED

Source sequence(s)

AC152503

Related

ENSMUST00000152729.8
NM_001405060.1 → NP_001391989.1 interleukin-10 receptor subunit beta isoform 4

Status: VALIDATED

Source sequence(s)

AC152503
NM_001405062.1 → NP_001391991.1 interleukin-10 receptor subunit beta isoform 5 precursor

Status: VALIDATED

Source sequence(s)

AC152503
NM_008349.6 → NP_032375.2 interleukin-10 receptor subunit beta isoform 1 precursor

See identical proteins and their annotated locations for NP_032375.2

Status: VALIDATED

Source sequence(s)

AC152503

Consensus CDS

CCDS37398.1

UniProtKB/Swiss-Prot

Q61190

UniProtKB/TrEMBL

Q8VHM7

Related

ENSMUSP00000023691.6, ENSMUST00000023691.12

Conserved Domains (2) summary

pfam09294
Location:113 → 214

Interfer-bind; Interferon-alpha/beta receptor, fibronectin type III

cl21522
Location:23 → 102

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...