Trh thyrotropin releasing hormone [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Trhprovided by MGI
Official Full Name: thyrotropin releasing hormoneprovided by MGI
Primary source: MGI:MGI:98823
See related: Ensembl:ENSMUSG00000005892 AllianceGenome:MGI:98823
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Trf; Pro-TRH
Summary: This gene encodes a member of the thyrotropin-releasing hormone family. Cleavage of the encoded proprotein releases mature thyrotropin-releasing hormone, which is a tripeptide hypothalamic regulatory hormone. The mouse proprotein contains five thyrotropin-releasing hormone tripeptides. Thyrotropin-releasing hormone is involved in the regulation and release of thyroid-stimulating hormone, as well as prolactin. Disruption of this gene results in hypothyroidism, elevated thyroid-stimulating hormone levels, and hyperglycemia. [provided by RefSeq, Apr 2013]
Expression: Biased expression in frontal lobe adult (RPKM 13.0), testis adult (RPKM 2.3) and 5 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 D1; 6 41.03 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (92219042..92221631, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (92242061..92244650, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Role of Thyrotropin-Releasing Hormone in Regulating Fibroblast Growth Factor 21 in Mouse Pancreatic beta Cells.
Title: Role of Thyrotropin-Releasing Hormone in Regulating Fibroblast Growth Factor 21 in Mouse Pancreatic β Cells.
Our results point out that cardiac TRH is required for AngII-induced hypertrophic and fibrotic effects.
Title: Angiotensin II requires an intact cardiac thyrotropin-releasing hormone (TRH) system to induce cardiac hypertrophy in mouse.
TGFbeta2 regulates hypothalamic TRH expression through TIEG1 during fetal development.
Title: TGFβ2 regulates hypothalamic Trh expression through the TGFβ inducible early gene-1 (TIEG1) during fetal development.
co-regulation of the enzyme glutaminyl cyclase and its substrate TRH was reflected by a co-induction of both proteins in reactive astrocytes in proximity of Abeta deposits
Title: Identification of thyrotropin-releasing hormone as hippocampal glutaminyl cyclase substrate in neurons and reactive astrocytes.
RXRA and RXRB display specific roles in modulating T3-dependent regulation of thyrotropin releasing hormone.
Title: Retinoic X receptor subtypes exert differential effects on the regulation of Trh transcription.
Reversal of hypothyroidism in female patient after treatment with thyrotropin releasing hormone.
Title: Hypothalamic hypothyroidism due to isolated thyrotropin-releasing hormone (TRH) deficiency.
Data suggest that expression of TRH is up-regulated by CREM (cAMP responsive element modulator protein) in hypothalamus; however, regulation of TRH by triiodothyronine appears independent of CREM or CREB (cAMP responsive element binding protein).
Title: Family members CREB and CREM control thyrotropin-releasing hormone (TRH) expression in the hypothalamus.
Thyrotropin-releasing hormone altered the basal expression of the TSHbeta gene and the responsiveness of the gene to thyroid hormone.
Title: NR4A1 (Nur77) mediates thyrotropin-releasing hormone-induced stimulation of transcription of the thyrotropin β gene: analysis of TRH knockout mice.
Klf4 plays a key role in the maturation of TRH expression in hypothalamic neurons.
Title: The Krüppel-like factor 4 controls biosynthesis of thyrotropin-releasing hormone during hypothalamus development.
Data demonstrate that the distribution of hypophysiotropic TRH neurons in mice is vastly different from the pattern in rats, with a dominant occurrence of these neurosecretory cells in the compact part and adjacent regions at the mid-level of the PVN.
Title: Distribution of hypophysiotropic thyrotropin-releasing hormone (TRH)-synthesizing neurons in the hypothalamic paraventricular nucleus of the mouse.

Submit: New GeneRIF Correction See all GeneRIFs (25)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4) 1 citation
Targeted (2) 1 citation

General gene information

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Markers

Trh (e-PCR), detects polymorphism
- UniSTS:507403

Trh (e-PCR), detects polymorphism
- UniSTS:507404

Trh (e-PCR), detects polymorphism
- UniSTS:144669

Trh (e-PCR), detects polymorphism
- UniSTS:516158

RH125311 (e-PCR)
- UniSTS:162133

AI324969 (e-PCR)
- UniSTS:165479

X59387 (e-PCR)
- UniSTS:125812

PMC304098P6 (e-PCR)
- UniSTS:272525

Trh (e-PCR), detects polymorphism
- UniSTS:547476

PMC317216P3 (e-PCR)
- UniSTS:273081

NoName (e-PCR)
- UniSTS:235502

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables thyrotropin-releasing hormone activity	IBA Inferred from Biological aspect of Ancestor more info
enables thyrotropin-releasing hormone activity	ISO Inferred from Sequence Orthology more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within adult walking behavior	IGI Inferred from Genetic Interaction more info	PubMed
involved_in eating behavior	IBA Inferred from Biological aspect of Ancestor more info
involved_in eating behavior	IEA Inferred from Electronic Annotation more info
involved_in eating behavior	ISO Inferred from Sequence Orthology more info
involved_in histamine metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in histamine metabolic process	IEA Inferred from Electronic Annotation more info
involved_in histamine metabolic process	ISO Inferred from Sequence Orthology more info
involved_in hormone-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of feeding behavior	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of feeding behavior	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of glutamate secretion	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of glutamate secretion	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of glutamate secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gamma-aminobutyric acid secretion	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of gamma-aminobutyric acid secretion	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of gamma-aminobutyric acid secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of insulin secretion	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of insulin secretion	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of insulin secretion	ISO Inferred from Sequence Orthology more info
involved_in response to corticosterone	IEA Inferred from Electronic Annotation more info
involved_in response to ethanol	IEA Inferred from Electronic Annotation more info
involved_in response to glucose	IEA Inferred from Electronic Annotation more info
involved_in response to hypoxia	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in secretory granule	IBA Inferred from Biological aspect of Ancestor more info
located_in secretory granule	IEA Inferred from Electronic Annotation more info
located_in secretory granule	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: thyrotropin releasing hormone

Names: TSH-releasing factor; pro-thyrotropin-releasing hormone; prothyroliberin; protirelin; thyrotropin-releasing factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.