Lama1 laminin, alpha 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Lama1provided by MGI
Official Full Name: laminin, alpha 1provided by MGI
Primary source: MGI:MGI:99892
See related: Ensembl:ENSMUSG00000032796 AllianceGenome:MGI:99892
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Lama
Summary: Enables glycosphingolipid binding activity. An extracellular matrix structural constituent. Involved in protein phosphorylation. Acts upstream of or within several processes, including morphogenesis of an epithelium; neuron projection development; and retinal blood vessel morphogenesis. Located in basement membrane and cell-cell junction. Part of laminin-1 complex. Is expressed in several structures, including alimentary system; early conceptus; eye; genitourinary system; and nervous system. Orthologous to human LAMA1 (laminin subunit alpha 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in ovary adult (RPKM 19.3), placenta adult (RPKM 10.0) and 8 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 E1.1; 17 38.8 cM

Exon count:: 65

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (68004129..68129640)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (67697127..67822645)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Lama1 upregulation prolongs the lifespan of the dy[H]/dy[H] mouse model of LAMA2-related congenital muscular dystrophy.
Title: Lama1 upregulation prolongs the lifespan of the dy(H)/dy(H) mouse model of LAMA2-related congenital muscular dystrophy.
Effects of experimental glaucoma in Lama1[nmf223] mutant mice.
Title: Effects of experimental glaucoma in Lama1(nmf223) mutant mice.
Effect of laminin environments and tumor factors on the biology of myeloid dendritic cells.
Title: Effect of laminin environments and tumor factors on the biology of myeloid dendritic cells.
Sleep deprivation regulates availability of PrP(C) and Abeta peptides which can impair interaction between PrP(C) and laminin and neuronal plasticity.
Title: Sleep deprivation regulates availability of PrP(C) and Aβ peptides which can impair interaction between PrP(C) and laminin and neuronal plasticity.
Lama1 as the genetic modifier of TGF-beta1 effector responses that significantly affects the development of pulmonary fibrosis.
Title: Laminin α1 is a genetic modifier of TGF-β1-stimulated pulmonary fibrosis.
Laminin alpha1 reduces muscular dystrophy in dy(2J) mice.
Title: Laminin α1 reduces muscular dystrophy in dy(2J) mice.
laminin-1 does not have a positive effect on ENCC migration in HD mice on E12.5, in contrast to the phenomenon seen in normal mice gut specimens, where laminin-1 promotes ENCC migration during the same period.
Title: The effect of laminin-1 on enteric neural crest-derived cell migration in the Hirschsprung's disease mouse model.
Altered LAMA1 expression in the aganglionic region may contribute to impaired ENCC migration, resulting in HD. These data could help in understanding the pathophysiologic interactions between LAMA1 and ENCC migration
Title: Altered expression of laminin alpha1 in aganglionic colon of endothelin receptor-B null mouse model of Hirschsprung's disease.
Laminin is instructive and CaMKII is non-permissive for the formation of complex aggregates of acetylcholine receptors on myotubes in culture.
Title: Laminin is instructive and calmodulin dependent kinase II is non-permissive for the formation of complex aggregates of acetylcholine receptors on myotubes in culture.
Laminin differentially regulates the stemness of type I and type II pericytes.
Title: Laminin differentially regulates the stemness of type I and type II pericytes.

Submit: New GeneRIF Correction See all GeneRIFs (46)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1) 1 citation
Endonuclease-mediated (1)
Gene trapped (1) 1 citation
Targeted (8) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH124719 (e-PCR)
- UniSTS:161541

Lama1 (e-PCR), detects polymorphism
- UniSTS:256619

BB445216 (e-PCR)
- UniSTS:209332

J04064 (e-PCR)
- UniSTS:124854

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables extracellular matrix structural constituent	IBA Inferred from Biological aspect of Ancestor more info
enables extracellular matrix structural constituent	IDA Inferred from Direct Assay more info	PubMed
enables extracellular matrix structural constituent	RCA inferred from Reviewed Computational Analysis more info	PubMed
enables glycosphingolipid binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in animal organ morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in axon guidance	IBA Inferred from Biological aspect of Ancestor more info
involved_in blood vessel morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within branching involved in salivary gland morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in camera-type eye development	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell surface receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within epithelial tube branching involved in lung morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within establishment of epithelial cell apical/basal polarity	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within morphogenesis of an epithelial sheet	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neuron projection development	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cell adhesion	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of integrin-mediated signaling pathway	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of muscle cell differentiation	NAS Non-traceable Author Statement more info	PubMed
involved_in protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of basement membrane organization	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of cell migration	IEA Inferred from Electronic Annotation more info
involved_in regulation of embryonic development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within retina development in camera-type eye	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within retinal blood vessel morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in tissue development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within tissue development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in basement membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in basement membrane	IDA Inferred from Direct Assay more info	PubMed
located_in basement membrane	ISO Inferred from Sequence Orthology more info
located_in basement membrane	NAS Non-traceable Author Statement more info	PubMed
located_in basement membrane	TAS Traceable Author Statement more info	PubMed
located_in cell-cell junction	IDA Inferred from Direct Assay more info	PubMed
located_in collagen-containing extracellular matrix	HDA more info	PubMed
located_in extracellular matrix	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	TAS Traceable Author Statement more info
located_in extracellular space	HDA more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info
part_of laminin complex	IDA Inferred from Direct Assay more info	PubMed
part_of laminin-1 complex	IDA Inferred from Direct Assay more info	PubMed
part_of laminin-1 complex	ISO Inferred from Sequence Orthology more info
part_of laminin-3 complex	IEA Inferred from Electronic Annotation more info
part_of laminin-3 complex	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	ISO Inferred from Sequence Orthology more info
part_of protein complex involved in cell-matrix adhesion	NAS Non-traceable Author Statement more info	PubMed

General protein information

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Preferred Names: laminin subunit alpha-1

Names: S-LAM alpha; S-laminin subunit alpha; laminin A chain; laminin-1 subunit alpha; laminin-3 subunit alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_008480.2 → NP_032506.2 laminin subunit alpha-1 precursor

Status: VALIDATED

Source sequence(s)

AC154823, AK051116, CA535780, CN461817, CN535171, J04064

Consensus CDS

CCDS37681.1

UniProtKB/Swiss-Prot

F8VQ40, P19137

Related

ENSMUSP00000043957.8, ENSMUST00000035471.9

Conserved Domains (10) summary

smart00136
Location:25 → 275

LamNT; Laminin N-terminal domain (domain VI)

smart00180
Location:958 → 1002

EGF_Lam; Laminin-type epidermal growth factor-like domai

cd00055
Location:1516 → 1553

EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

cd00110
Location:2900 → 3053

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam00053
Location:909 → 955

Laminin_EGF; Laminin EGF domain

pfam00054
Location:2751 → 2880

Laminin_G_1; Laminin G domain

pfam06009
Location:2018 → 2152

Laminin_II; Laminin Domain II

pfam00052
Location:575 → 714

Laminin_B; Laminin B (Domain IV)

pfam06008
Location:1582 → 1837

Laminin_I; Laminin Domain I

cl25642
Location:1827 → 2064

DUF390; Protein of unknown function (DUF390)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000083.7 Reference GRCm39 C57BL/6J

Range

68004129..68129640

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006523718.5 → XP_006523781.1 laminin subunit alpha-1 isoform X3

Conserved Domains (5) summary

smart00136
Location:25 → 275

LamNT; Laminin N-terminal domain (domain VI)

smart00180
Location:958 → 1002

EGF_Lam; Laminin-type epidermal growth factor-like domai

cd00055
Location:1516 → 1553

EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

pfam00052
Location:575 → 714

Laminin_B; Laminin B (Domain IV)

pfam00053
Location:909 → 955

Laminin_EGF; Laminin EGF domain
XM_006523717.5 → XP_006523780.1 laminin subunit alpha-1 isoform X1

Conserved Domains (10) summary

smart00136
Location:25 → 275

LamNT; Laminin N-terminal domain (domain VI)

smart00180
Location:958 → 1002

EGF_Lam; Laminin-type epidermal growth factor-like domai

COG4372
Location:1737 → 2044

COG4372; Uncharacterized conserved protein, contains DUF3084 domain [Function unknown]

cd00055
Location:1516 → 1553

EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

cd00110
Location:2314 → 2470

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam06008
Location:1582 → 1837

Laminin_I; Laminin Domain I

pfam00054
Location:2751 → 2880

Laminin_G_1; Laminin G domain

pfam00052
Location:575 → 714

Laminin_B; Laminin B (Domain IV)

pfam00053
Location:909 → 955

Laminin_EGF; Laminin EGF domain

pfam06009
Location:2018 → 2152

Laminin_II; Laminin Domain II
XM_030249517.2 → XP_030105377.1 laminin subunit alpha-1 isoform X2

Conserved Domains (10) summary

smart00180
Location:713 → 757

EGF_Lam; Laminin-type epidermal growth factor-like domai

COG4372
Location:1492 → 1799

COG4372; Uncharacterized conserved protein, contains DUF3084 domain [Function unknown]

cd00055
Location:1271 → 1308

EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

cd00110
Location:2655 → 2808

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam06008
Location:1337 → 1592

Laminin_I; Laminin Domain I

pfam00054
Location:2506 → 2635

Laminin_G_1; Laminin G domain

pfam00052
Location:330 → 469

Laminin_B; Laminin B (Domain IV)

pfam00053
Location:664 → 710

Laminin_EGF; Laminin EGF domain

pfam06009
Location:1773 → 1907

Laminin_II; Laminin Domain II

cl02806
Location:7 → 30

Laminin_N; Laminin N-terminal (Domain VI)
XM_030249518.2 → XP_030105378.1 laminin subunit alpha-1 isoform X2

Conserved Domains (10) summary

smart00180
Location:713 → 757

EGF_Lam; Laminin-type epidermal growth factor-like domai

COG4372
Location:1492 → 1799

COG4372; Uncharacterized conserved protein, contains DUF3084 domain [Function unknown]

cd00055
Location:1271 → 1308

EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

cd00110
Location:2655 → 2808

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam06008
Location:1337 → 1592

Laminin_I; Laminin Domain I

pfam00054
Location:2506 → 2635

Laminin_G_1; Laminin G domain

pfam00052
Location:330 → 469

Laminin_B; Laminin B (Domain IV)

pfam00053
Location:664 → 710

Laminin_EGF; Laminin EGF domain

pfam06009
Location:1773 → 1907

Laminin_II; Laminin Domain II

cl02806
Location:7 → 30

Laminin_N; Laminin N-terminal (Domain VI)