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    Clca3a1 chloride channel accessory 3A1 [ Mus musculus (house mouse) ]

    Gene ID: 12722, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Clca3a1provided by MGI
    Official Full Name
    chloride channel accessory 3A1provided by MGI
    Primary source
    MGI:MGI:1316732
    See related
    Ensembl:ENSMUSG00000056025 AllianceGenome:MGI:1316732
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cacc; Clca1
    Summary
    Enables intracellularly calcium-gated chloride channel activity. Acts upstream of or within chloride transport. Located in plasma membrane. Is expressed in several structures, including brain; cranial nerve; genitourinary system; gut; and skeleton. Orthologous to human CLCA3P (chloride channel accessory 3, pseudogene). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in bladder adult (RPKM 11.5), liver E18 (RPKM 11.1) and 18 other tissues See more
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    Genomic context

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    See Clca3a1 in Genome Data Viewer
    Location:
    3 H2; 3 69.06 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (144435438..144466738, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (144729677..144760977, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_09183 Neighboring gene STARR-positive B cell enhancer ABC_E7949 Neighboring gene SH3-domain GRB2-like B1 (endophilin) Neighboring gene STARR-positive B cell enhancer mm9_chr3:144367228-144367528 Neighboring gene STARR-positive B cell enhancer ABC_E2099 Neighboring gene BCL2/adenovirus E1B interacting protein 3 pseudogene Neighboring gene predicted gene, 34866 Neighboring gene nuclear receptor subfamily 5, group A, member 2 pseudogene Neighboring gene chloride channel accessory 3A2 Neighboring gene chloride channel accessory 3B Neighboring gene STARR-seq mESC enhancer starr_09185 Neighboring gene proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Molecular and functional characterization of a calcium-sensitive chloride channel from mouse lung. Gandhi R, et al. J Biol Chem, 1998 Nov 27. PMID 9822685
    2. Axotomy-induced expression of calcium-activated chloride current in subpopulations of mouse dorsal root ganglion neurons. André S, et al. J Neurophysiol, 2003 Dec. PMID 12944538
    3. Characterization of a murine gene homologous to the bovine CaCC chloride channel. Romio L, et al. Gene, 1999 Mar 4. PMID 10072771
    4. Lymphatic endothelial murine chloride channel calcium-activated 1 is a ligand for leukocyte LFA-1 and Mac-1. Furuya M, et al. J Immunol, 2010 Nov 15. PMID 20937843, Free PMC Article
    5. Cell cycle-dependent activity of the volume- and Ca2+-activated anion currents in Ehrlich lettre ascites cells. Klausen TK, et al. J Cell Physiol, 2007 Mar. PMID 17111356

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Serine 727 phosphorylation in TMEM16A by CaMKIIgamma provides a new mechanism for regulating TMEM16A CaCC activity and Ang II-induced BASMC proliferation.
      Title: Ca(2+)/Calmodulin-Dependent Protein Kinase II γ-Dependent Serine727 Phosphorylation Is Required for TMEM16A Ca(2+)-Activated Cl(-) Channel Regulation in Cerebrovascular Cells.
    2. Together the data suggests that Ca(2+) entry via the TRPC1 channels is essential for the activation of CaCC
      Title: TRPC1 regulates calcium-activated chloride channels in salivary gland cells.
    3. murine chloride channel calcium-activated was discovered to be a lymphatic endothelial surface ligand for LFA-1 and Mac-1
      Title: Lymphatic endothelial murine chloride channel calcium-activated 1 is a ligand for leukocyte LFA-1 and Mac-1.
    4. The apical membrane localization and overall distribution pattern of mCLCA1 favor a transmembrane protein implicated in transepithelial ion transport and protein secretion.
      Title: Cellular distribution and subcellular localization of mCLCA1/2 in murine gastrointestinal epithelia.
    5. Clca1 may be part of the genomic death program triggered by extrasynaptic NMDA receptors; it could be a marker for ischemic brain damage and a possible target for therapeutic interventions.
      Title: Hypoxic/ischemic conditions induce expression of the putative pro-death gene Clca1 via activation of extrasynaptic N-methyl-D-aspartate receptors.
    6. The large conductance potassium channel beta-subunit can interact with and modulate the functional properties of a calcium-activated chloride channel, CLCA1
      Title: The large conductance potassium channel beta-subunit can interact with and modulate the functional properties of a calcium-activated chloride channel, CLCA1.
    7. Quantitation of mCLCA1 and mCLCA2 in 19 pre- and 44 postnatal murine tissues reveals differentially regulated expression in pre- and postnatal murine tissues
      Title: Real-time RT-PCR quantitation of mCLCA1 and mCLCA2 reveals differentially regulated expression in pre- and postnatal murine tissues.
    8. beta(4) integrin ligation to its novel CLCA-adhesion partner is shown to be associated with FAK complexing, activation, and signaling to promote early, intravascular, metastatic growth.
      Title: Focal adhesion kinase activated by beta(4) integrin ligation to mCLCA1 mediates early metastatic growth.
    9. channels play a specific role in postinjury behavior of sensory neuron subpopulations
      Title: Axotomy-induced expression of calcium-activated chloride current in subpopulations of mouse dorsal root ganglion neurons.
    10. In Ehrlich Lettre Ascites Cells, entrance into the S phase requires an increase in volume-regulated anion current activity and/or an increased potential for regulatory volume decrease (RVD), and at the same time a decrease in CaCC magnitude.
      Title: Cell cycle-dependent activity of the volume- and Ca2+-activated anion currents in Ehrlich lettre ascites cells.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables intracellularly calcium-gated chloride channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables intracellularly calcium-gated chloride channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metallopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chloride transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within chloride transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    calcium-activated chloride channel regulator 3A-1
    Names
    chloride channel calcium activated 1
    chloride channel calcium activated 3A1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009899.4 → NP_034029.2  calcium-activated chloride channel regulator 3A-1 precursor

      See identical proteins and their annotated locations for NP_034029.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the functional protein.
      Source sequence(s)
      AC137128, AK137904, AK161805
      Consensus CDS
      CCDS17886.1
      UniProtKB/Swiss-Prot
      B7ZN73, O88860, Q3UQR1, Q8C324, Q8CCM1, Q9QX15
      UniProtKB/TrEMBL
      Q9R070
      Related
      ENSMUSP00000054526.6, ENSMUST00000059091.6
      Conserved Domains (1) summary
      TIGR00868
      Location:1 → 865
      hCaCC; calcium-activated chloride channel protein 1

    RNA

    1. NR_130895.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC137128, AK137904, AK161805
      Related
      ENSMUST00000029932.14

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      144435438..144466738 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011240004.1 → XP_011238306.1  calcium-activated chloride channel regulator 3A-1 isoform X2

      Conserved Domains (1) summary
      TIGR00868
      Location:35 → 714
      hCaCC; calcium-activated chloride channel protein 1

    2. XM_006500965.5 → XP_006501028.1  calcium-activated chloride channel regulator 3A-1 isoform X1

      UniProtKB/TrEMBL
      Q9R070
      Conserved Domains (1) summary
      TIGR00868
      Location:1 → 788
      hCaCC; calcium-activated chloride channel protein 1

    RNA

    1. XR_004941270.1 RNA Sequence

    2. XR_003954276.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9QX15.1 GenPept UniProtKB/Swiss-Prot:Q9QX15

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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