Sall2 spalt like transcription factor 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Sall2provided by MGI
Official Full Name: spalt like transcription factor 2provided by MGI
Primary source: MGI:MGI:1354373
See related: Ensembl:ENSMUSG00000049532 AllianceGenome:MGI:1354373
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Sal-2; Msal-2; mKIAA0360; p150(Sal2)
Summary: Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II. Acts upstream of or within neural tube development. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; metanephros; neural ectoderm; reproductive system; and sensory organ. Human ortholog(s) of this gene implicated in coloboma. Orthologous to human SALL2 (spalt like transcription factor 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in CNS E11.5 (RPKM 18.6), whole brain E14.5 (RPKM 18.0) and 18 other tissues See more
Orthologs: human all
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Genomic context

Location:: 14 C2; 14 26.89 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (52548634..52566127, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (52311177..52328670, complement)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SALL2 is a negative regulator of cell proliferation, an effect mediated in part by repression of G1-S cyclins' expression.
Title: SALL2 represses cyclins D1 and E1 expression and restrains G1/S cell cycle transition and cancer-related phenotypes.
In addition, studies in leukemia Jurkat T cells support the existence of the Sall2/Noxa axis, and the significance of this axis on the apoptotic response to doxorubicin in cancer cells.
Title: Sall2 is required for proapoptotic Noxa expression and genotoxic stress-induced apoptosis by doxorubicin.
Data show that p53 activation diminished SALL2 RNA and protein levels during genotoxic cellular stress in primary embryo fibroblasts (MEFs).
Title: Wild type p53 transcriptionally represses the SALL2 transcription factor under genotoxic stress.
These data establish Sall2 as a link between p75 neurotrophin receptor and transcriptional events that regulate the growth and development of neuronal cells.
Title: Sall2 is a novel p75NTR-interacting protein that links NGF signalling to cell cycle progression and neurite outgrowth.
A fundamental and redundant function of the Sall proteins in murine neurulation, is shown.
Title: Sall1, sall2, and sall4 are required for neural tube closure in mice.
Results suggest that p150(Sal2), acting in part as a p53-independent regulator of p21 and BAX, can function in some cell types as a regulator of cell growth and survival.
Title: p150(Sal2) is a p53-independent regulator of p21(WAF1/CIP).
We have now generated mice lacking Sall2.Mice lacking both Sall1 and Sall2 show kidney phenotypes comparable to those of Sall1 knockout, thereby demonstrating the dispensable roles of Sall2 in embryonic and kidney development
Title: Zinc finger protein sall2 is not essential for embryonic and kidney development.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI576082 (e-PCR)
- UniSTS:248608

RH135974 (e-PCR)
- UniSTS:209970

PMC140661P1 (e-PCR)
- UniSTS:270951

MARC_14473-14474:1010604369:1 (e-PCR)
- UniSTS:267682

AW559097 (e-PCR)
- UniSTS:180649

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein-containing complex binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in eye development	ISO Inferred from Sequence Orthology more info
involved_in eye development	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within neural tube development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: sal-like protein 2

Names: sal-like 2; spalt-like protein 2; zinc finger protein Spalt-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001244916.1 → NP_001231845.1 sal-like protein 2 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' exon which includes 5' UTR and 5' coding region, compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus, compared to isoform 1.

Source sequence(s)

AI645468, AK077601, BC085361, CB520889

Consensus CDS

CCDS88663.1

UniProtKB/TrEMBL

A0A2I3BQV4, Q8BP69

Related

ENSMUSP00000154331.2, ENSMUST00000135523.5

Conserved Domains (3) summary

sd00017
Location:372 → 392

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:688 → 709

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:384 → 409

zf-H2C2_2; Zinc-finger double domain
NM_015772.3 → NP_056587.2 sal-like protein 2 isoform 1

See identical proteins and their annotated locations for NP_056587.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer protein (isoform 1).

Source sequence(s)

AC126037, AI645468, BC085361

Consensus CDS

CCDS27054.1

UniProtKB/Swiss-Prot

Q5U3X1, Q9QX96

UniProtKB/TrEMBL

Q8BP69

Related

ENSMUSP00000056401.5, ENSMUST00000058326.6

Conserved Domains (3) summary

sd00017
Location:374 → 394

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:690 → 711

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:386 → 411

zf-H2C2_2; Zinc-finger double domain