Liph lipase, member H [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Liphprovided by MGI
Official Full Name: lipase, member Hprovided by MGI
Primary source: MGI:MGI:2388029
See related: Ensembl:ENSMUSG00000044626 AllianceGenome:MGI:2388029
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: P3; H06; lpd1; lpd2; Lpdlr; PLA1B; mPA-PLA1; D16Wsu119e; C130037N08Rik
Summary: Predicted to enable heparin binding activity and phospholipase activity. Predicted to be involved in lipid catabolic process. Predicted to be located in extracellular region and plasma membrane. Predicted to be active in extracellular space. Is expressed in several structures, including anal canal; epidermis; genitourinary system; gut; and hippocampus. Human ortholog(s) of this gene implicated in hypotrichosis 7. Orthologous to human LIPH (lipase H). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in placenta adult (RPKM 8.8), large intestine adult (RPKM 8.0) and 7 other tissues See more
Orthologs: human all
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Genomic context

Location:: 16 B1; 16 12.95 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	16	NC_000082.7 (21772567..21814408, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	16	NC_000082.6 (21953817..21995658, complement)

Chromosome 16 - NC_000082.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

We finally isolate control and Enpp2-null dermal pipilla precursors and identify the expression and upregulation of LIPH, an alternative LPA-producing enzyme, suggesting that this gene could functionally compensate for the absence of Enpp2.
Title: Enpp2/Autotaxin in dermal papilla precursors is dispensable for hair follicle morphogenesis.

Submit: New GeneRIF Correction

Phenotypes

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Associated conditions

Description	Tests
lipid defect 1 GeneReviews: Not available

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Gene trapped (1)
Targeted (1) 1 citation

General gene information

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Markers

D16Wsu119e (e-PCR), detects polymorphism
- UniSTS:142096

D16Mit35 (e-PCR), detects polymorphism
- UniSTS:127871

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables heparin binding	IEA Inferred from Electronic Annotation more info
enables heparin binding	ISO Inferred from Sequence Orthology more info
enables phospholipase activity	IBA Inferred from Biological aspect of Ancestor more info
enables phospholipase activity	IEA Inferred from Electronic Annotation more info
enables phospholipase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in lipid catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in lipid catabolic process	IEA Inferred from Electronic Annotation more info
involved_in lipid catabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in extracellular region	ISO Inferred from Sequence Orthology more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IEA Inferred from Electronic Annotation more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: lipase member H

Names: lipase H

NP_001077363.1

EC 2.7.11.30

NP_001276510.1

EC 2.7.11.30

NP_001276511.1

EC 2.7.11.30

NP_700453.1

EC 2.7.11.30

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001083894.1 → NP_001077363.1 lipase member H isoform 1 precursor

See identical proteins and their annotated locations for NP_001077363.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1).

Source sequence(s)

AK134352, AK162492, BQ032777, BY118220

Consensus CDS

CCDS37296.1

UniProtKB/Swiss-Prot

Q3TRT3, Q3TTZ0, Q3UWA2, Q8BXB5, Q8CI45, Q8CIV3

Related

ENSMUSP00000062310.7, ENSMUST00000060673.8

Conserved Domains (1) summary

cd00707
Location:41 → 310

Pancreat_lipase_like; Pancreatic lipase-like enzymes. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the ...
NM_001289581.1 → NP_001276510.1 lipase member H isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (3) uses two alternate splice sites in the 5' UTR and coding region compared to variant 1. These differences cause translation initiation at a downstream start codon compared to variant 1. The encoded isoform (3) has a shorter N-terminus compared to isoform 1.

Source sequence(s)

AK137278, BQ032777, CT030725

Conserved Domains (1) summary

cl21494
Location:1 → 161

Abhydrolase; alpha/beta hydrolases
NM_001289582.1 → NP_001276511.1 lipase member H isoform 4 precursor

See identical proteins and their annotated locations for NP_001276511.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) uses an alternate in-frame splice site compared to variant 1. The encoded isoform (4) is shorter than isoform 1.

Source sequence(s)

AK048150, BQ032777, CT030725

Consensus CDS

CCDS88903.1

UniProtKB/Swiss-Prot

Q8CIV3

Related

ENSMUSP00000156378.2, ENSMUST00000231766.2

Conserved Domains (1) summary

cd00707
Location:41 → 308

Pancreat_lipase_like; Pancreatic lipase-like enzymes. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the ...
NM_153404.3 → NP_700453.1 lipase member H isoform 2 precursor

See identical proteins and their annotated locations for NP_700453.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an in-frame exon in the central coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.

Source sequence(s)

BQ032777, CT030725

Consensus CDS

CCDS37295.1

UniProtKB/Swiss-Prot

Q8CIV3

Related

ENSMUSP00000073853.5, ENSMUST00000074230.12

Conserved Domains (1) summary

cd00707
Location:41 → 280

Pancreat_lipase_like; Pancreatic lipase-like enzymes. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the ...