Dock2 dedicator of cyto-kinesis 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dock2provided by MGI
Official Full Name: dedicator of cyto-kinesis 2provided by MGI
Primary source: MGI:MGI:2149010
See related: Ensembl:ENSMUSG00000020143 AllianceGenome:MGI:2149010
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Hch; MBC; CED-5
Summary: Enables GTPase activator activity. Involved in macropinocytosis; myeloid dendritic cell activation involved in immune response; and positive regulation of phagocytosis. Acts upstream of or within several processes, including T cell activation; immunological synapse formation; and membrane raft polarization. Predicted to be located in cytoskeleton; endomembrane system; and membrane. Predicted to be active in cytoplasm and plasma membrane. Is expressed in central nervous system; paraxial mesenchyme; and retina. Human ortholog(s) of this gene implicated in immunodeficiency 40. Orthologous to human DOCK2 (dedicator of cytokinesis 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in spleen adult (RPKM 15.3), thymus adult (RPKM 14.5) and 11 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 A4; 11 19.68 cM

Exon count:: 53

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (34176815..34674732, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (34226815..34783905, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

DOCK2 Promotes Atherosclerosis by Mediating the Endothelial Cell Inflammatory Response.
Title: DOCK2 Promotes Atherosclerosis by Mediating the Endothelial Cell Inflammatory Response.
Dock2 generates characteristic spatiotemporal patterns of Rac activity to regulate neutrophil polarisation, migration and phagocytosis.
Title: Dock2 generates characteristic spatiotemporal patterns of Rac activity to regulate neutrophil polarisation, migration and phagocytosis.
DOCK2 regulates MRGPRX2/B2-mediated mast cell degranulation and drug-induced anaphylaxis.
Title: DOCK2 regulates MRGPRX2/B2-mediated mast cell degranulation and drug-induced anaphylaxis.
DOCK2 Deficiency Attenuates Abdominal Aortic Aneurysm Formation-Brief Report.
Title: DOCK2 Deficiency Attenuates Abdominal Aortic Aneurysm Formation-Brief Report.
DOCK2 and phosphoinositide-3 kinase delta mediate two complementary signaling pathways for CXCR5-dependent B cell migration.
Title: DOCK2 and phosphoinositide-3 kinase δ mediate two complementary signaling pathways for CXCR5-dependent B cell migration.
DOCK2 contributes to pulmonary fibrosis by promoting lung fibroblast to myofibroblast transition.
Title: DOCK2 contributes to pulmonary fibrosis by promoting lung fibroblast to myofibroblast transition.
Dedicator of Cytokinesis 2 (DOCK2) Silencing Protects Against Cerebral Ischemia/Reperfusion by Modulating Microglia Polarization via the Activation of the STAT6 Signaling Pathway.
Title: Dedicator of Cytokinesis 2 (DOCK2) Silencing Protects Against Cerebral Ischemia/Reperfusion by Modulating Microglia Polarization via the Activation of the STAT6 Signaling Pathway.
DOCK2 regulates antifungal immunity by regulating RAC GTPase activity.
Title: DOCK2 regulates antifungal immunity by regulating RAC GTPase activity.
Dedicator of Cytokinesis 2 (DOCK2) Deficiency Attenuates Lung Injury Associated with Chronic High-Fat and High-Fructose Diet-Induced Obesity.
Title: Dedicator of Cytokinesis 2 (DOCK2) Deficiency Attenuates Lung Injury Associated with Chronic High-Fat and High-Fructose Diet-Induced Obesity.
DOCK2 Promotes Pleural Fibrosis by Modulating Mesothelial to Mesenchymal Transition.
Title: DOCK2 Promotes Pleural Fibrosis by Modulating Mesothelial to Mesenchymal Transition.

Submit: New GeneRIF Correction See all GeneRIFs (46)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (19)
Endonuclease-mediated (3)
Spontaneous (1) 1 citation
Targeted (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI662014 (e-PCR)
- UniSTS:165747

AW122239 (e-PCR)
- UniSTS:180174

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GTPase activator activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables T cell receptor binding	ISO Inferred from Sequence Orthology more info
enables T cell receptor binding	ISS Inferred from Sequence or Structural Similarity more info
enables guanyl-nucleotide exchange factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables guanyl-nucleotide exchange factor activity	ISO Inferred from Sequence Orthology more info
enables guanyl-nucleotide exchange factor activity	ISS Inferred from Sequence or Structural Similarity more info
enables small GTPase binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within T cell activation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within T cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in actin cytoskeleton organization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within alpha-beta T cell activation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within alpha-beta T cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within chemotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cytoskeleton organization	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within establishment of T cell polarity	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within immunological synapse formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in macropinocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within membrane raft polarization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in myeloid dendritic cell activation involved in immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in myoblast fusion	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative thymic T cell selection	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of Rac protein signal transduction	IC Inferred by Curator more info	PubMed
involved_in positive regulation of phagocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive thymic T cell selection	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in small GTPase-mediated signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in endomembrane system	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: dedicator of cytokinesis protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_033374.3 → NP_203538.2 dedicator of cytokinesis protein 2

See identical proteins and their annotated locations for NP_203538.2

Status: VALIDATED

Source sequence(s)

AK037611, AK172915, BC040427, CR392356

Consensus CDS

CCDS83791.1

UniProtKB/Swiss-Prot

Q5SRI4, Q8C3J5, Q99M79

UniProtKB/TrEMBL

Q6A0A3

Related

ENSMUSP00000090884.6, ENSMUST00000093193.12

Conserved Domains (4) summary

cd11706
Location:1199 → 1619

DHR2_DOCK2; Dock Homology Region 2, a GEF domain, of Class A Dedicator of Cytokinesis 2

pfam16172
Location:78 → 414

DOCK_N; DOCK N-terminus

cl14603
Location:422 → 617

C2; C2 domain

cl17036
Location:12 → 67

SH3; Src Homology 3 domain superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

34176815..34674732 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017314862.3 → XP_017170351.1 dedicator of cytokinesis protein 2 isoform X1

UniProtKB/TrEMBL

Q6A0A3

Conserved Domains (3) summary

cd11706
Location:895 → 1315

DHR2_DOCK2; Dock Homology Region 2, a GEF domain, of Class A Dedicator of Cytokinesis 2

pfam16172
Location:12 → 110

DOCK_N; DOCK N-terminus

cl14603
Location:118 → 313

C2; C2 domain