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    Itga2 integrin alpha 2 [ Mus musculus (house mouse) ]

    Gene ID: 16398, updated on 13-Jan-2025

    Summary

    Official Symbol
    Itga2provided by MGI
    Official Full Name
    integrin alpha 2provided by MGI
    Primary source
    MGI:MGI:96600
    See related
    Ensembl:ENSMUSG00000015533 AllianceGenome:MGI:96600
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    DX5; GPIa; CD49B
    Summary
    Enables amyloid-beta binding activity. Predicted to be involved in several processes, including cell surface receptor signaling pathway; positive regulation of cell migration; and positive regulation of cellular component organization. Located in basal part of cell and external side of plasma membrane. Is expressed in several structures, including alimentary system; cardiovascular system; eye; genitourinary system; and nervous system. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); blood platelet disease (multiple); diabetes mellitus (multiple); retinal vascular disease (multiple); and von Willebrand's disease (multiple). Orthologous to human ITGA2 (integrin subunit alpha 2). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Broad expression in large intestine adult (RPKM 1.3), placenta adult (RPKM 1.3) and 21 other tissues See more
    Orthologs
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    Genomic context

    See Itga2 in Genome Data Viewer
    Location:
    13 D2.2; 13 64.61 cM
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (114969617..115068588, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (114833081..114932100, complement)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 53802 Neighboring gene predicted gene, 34790 Neighboring gene STARR-seq mESC enhancer starr_35767 Neighboring gene STARR-positive B cell enhancer ABC_E5421 Neighboring gene STARR-positive B cell enhancer mm9_chr13:115621672-115621973 Neighboring gene STARR-seq mESC enhancer starr_35768 Neighboring gene molybdenum cofactor synthesis 2 Neighboring gene predicted gene, 34845 Neighboring gene integrin alpha 1 Neighboring gene STARR-seq mESC enhancer starr_35769 Neighboring gene predicted gene 10734 Neighboring gene pelota mRNA surveillance and ribosome rescue factor Neighboring gene predicted gene, 41075 Neighboring gene predicted gene, 25985

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (5) 
    • Targeted (7)  1 citation

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables amyloid-beta binding PubMed 
    enables collagen binding  
    enables collagen binding involved in cell-matrix adhesion  
    enables collagen binding involved in cell-matrix adhesion  
    enables collagen receptor activity  
    enables collagen receptor activity  
    enables integrin binding  
    enables integrin binding  
    enables integrin binding  
    enables laminin binding  
    enables laminin binding  
    enables metal ion binding  
    enables protein-containing complex binding  
    Items 1 - 25 of 58
    Process Evidence Code Pubs
    involved_in cell adhesion mediated by integrin  
    involved_in cell adhesion mediated by integrin  
    involved_in cell adhesion mediated by integrin  
    involved_in cell-cell adhesion  
    involved_in cell-matrix adhesion  
    involved_in cell-matrix adhesion  
    involved_in cell-substrate adhesion  
    involved_in cellular response to estradiol stimulus  
    involved_in cellular response to mechanical stimulus  
    involved_in collagen-activated signaling pathway  
    involved_in collagen-activated signaling pathway  
    involved_in detection of mechanical stimulus involved in sensory perception of pain  
    involved_in detection of mechanical stimulus involved in sensory perception of pain  
    involved_in female pregnancy  
    involved_in focal adhesion assembly  
    involved_in focal adhesion assembly  
    involved_in hepatocyte differentiation  
    involved_in hypotonic response  
    involved_in hypotonic response  
    involved_in integrin-mediated signaling pathway  
    involved_in integrin-mediated signaling pathway  
    involved_in integrin-mediated signaling pathway  
    involved_in mammary gland development  
    involved_in mesodermal cell differentiation  
    involved_in positive regulation of cell adhesion  
    involved_in positive regulation of cell adhesion  
    involved_in positive regulation of cell projection organization  
    involved_in positive regulation of cell projection organization  
    involved_in positive regulation of collagen biosynthetic process  
    involved_in positive regulation of collagen biosynthetic process  
    involved_in positive regulation of epithelial cell migration  
    involved_in positive regulation of epithelial cell migration  
    involved_in positive regulation of leukocyte migration  
    involved_in positive regulation of leukocyte migration  
    involved_in positive regulation of phagocytosis, engulfment  
    involved_in positive regulation of phagocytosis, engulfment  
    involved_in positive regulation of positive chemotaxis  
    involved_in positive regulation of positive chemotaxis  
    involved_in positive regulation of smooth muscle cell migration  
    involved_in positive regulation of smooth muscle cell migration  
    involved_in positive regulation of smooth muscle cell proliferation  
    involved_in positive regulation of smooth muscle cell proliferation  
    involved_in positive regulation of smooth muscle contraction  
    involved_in positive regulation of smooth muscle contraction  
    involved_in positive regulation of translation  
    involved_in positive regulation of translation  
    involved_in positive regulation of transmission of nerve impulse  
    involved_in positive regulation of transmission of nerve impulse  
    involved_in response to L-ascorbic acid  
    involved_in response to amine  
    involved_in response to hypoxia  
    involved_in response to muscle activity  
    involved_in response to parathyroid hormone  
    involved_in response to xenobiotic stimulus  
    involved_in skin morphogenesis  
    involved_in skin morphogenesis  
    involved_in substrate-dependent cell migration  
    involved_in substrate-dependent cell migration  
    Items 1 - 25 of 58
    Component Evidence Code Pubs
    located_in axon  
    located_in axon terminus  
    located_in axon terminus  
    located_in basal part of cell PubMed 
    located_in cell projection  
    located_in cell surface PubMed 
    located_in cell surface  
    is_active_in external side of plasma membrane  
    located_in external side of plasma membrane PubMed 
    located_in focal adhesion  
    located_in focal adhesion  
    part_of integrin alpha2-beta1 complex  
    part_of integrin alpha2-beta1 complex  
    part_of integrin complex  
    located_in perinuclear region of cytoplasm  
    located_in perinuclear region of cytoplasm  
    located_in plasma membrane  
    located_in plasma membrane  
    is_active_in presynapse  

    General protein information

    Preferred Names
    integrin alpha-2
    Names
    CD49 antigen-like family member B
    VLA-2 receptor, alpha 2 subunit
    collagen receptor
    platelet membrane glycoprotein Ia

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008396.4NP_032422.2  integrin alpha-2 precursor

      See identical proteins and their annotated locations for NP_032422.2

      Status: VALIDATED

      Source sequence(s)
      CT025598
      Consensus CDS
      CCDS26787.1
      UniProtKB/Swiss-Prot
      Q62163, Q62469, Q6P1C7
      Related
      ENSMUSP00000053891.9, ENSMUST00000056117.10
      Conserved Domains (4) summary
      smart00191
      Location:548601
      Int_alpha; Integrin alpha (beta-propellor repeats)
      cd01469
      Location:170350
      vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...
      pfam00357
      Location:11521166
      Integrin_alpha; Integrin alpha cytoplasmic region
      pfam08441
      Location:6461057
      Integrin_alpha2; Integrin alpha

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      114969617..115068588 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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