Egr4 early growth response 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Egr4provided by MGI
Official Full Name: early growth response 4provided by MGI
Primary source: MGI:MGI:99252
See related: Ensembl:ENSMUSG00000071341 AllianceGenome:MGI:99252
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: NGFIC; NGF1-C; NGFI-C; pAT133
Summary: Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Is expressed in several structures, including central nervous system; genitourinary system; and tooth. Orthologous to human EGR4 (early growth response 4). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in frontal lobe adult (RPKM 10.9), cortex adult (RPKM 9.9) and 2 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 C3; 6 37.48 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (85488103..85490571, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (85511121..85513589, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Suppression of Ca(2+) signals by EGR4 controls Th1 differentiation and anti-cancer immunity in vivo.
Title: Suppression of Ca(2+) signals by EGR4 controls Th1 differentiation and anti-cancer immunity in vivo.
Egr4 expression is triggered by trophic factor neurturin to upregulate K-Cl cotransporter KCC2 in immature neurons.
Title: Neurturin evokes MAPK-dependent upregulation of Egr4 and KCC2 in developing neurons.
Egr4 is an important component in the mechanism of BDNF-dependent KCC2 gene regulation via the ERK1/2 pathway in immature neurons.
Title: Early growth response 4 mediates BDNF induction of potassium chloride cotransporter 2 transcription.
Data suggest that Egr4 may regulate spermatogenesis at multiple steps, with roles in the dividing Sertoli cells, peritubular myoid cells, and the meiotic and elongating haploid germ cell populations.
Title: EGR4 displays both a cell- and intracellular-specific localization pattern in the developing murine testis.
An important role for Egr4 is indicated in the developmental upregulation of potassium-chloride cotransporter (KCC2) gene expression.
Title: Upregulation of the neuron-specific K+/Cl- cotransporter expression by transcription factor early growth response 4.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (3) 1 citation

General gene information

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Markers

RH94566 (e-PCR)
- UniSTS:119814

NoName (e-PCR)
- UniSTS:493385

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: early growth response protein 4

Names: EGR-4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_020596.3 → NP_065621.1 early growth response protein 4

See identical proteins and their annotated locations for NP_065621.1

Status: VALIDATED

Source sequence(s)

AK141637, BX528200

Consensus CDS

CCDS20297.1

UniProtKB/Swiss-Prot

Q9WUF2

UniProtKB/TrEMBL

Q3URA9

Related

ENSMUSP00000093433.4, ENSMUST00000095759.5

Conserved Domains (4) summary

COG5048
Location:400 → 458

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:374 → 396

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:372 → 396

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:416 → 441

zf-H2C2_2; Zinc-finger double domain