Sigirr single immunoglobulin and toll-interleukin 1 receptor (TIR) domain [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Sigirrprovided by MGI
Official Full Name: single immunoglobulin and toll-interleukin 1 receptor (TIR) domainprovided by MGI
Primary source: MGI:MGI:1344402
See related: Ensembl:ENSMUSG00000025494 AllianceGenome:MGI:1344402
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: TIR8
Summary: Involved in acute-phase response; negative regulation of chemokine production; and negative regulation of interleukin-1-mediated signaling pathway. Predicted to be located in membrane. Predicted to be active in cell surface and plasma membrane. Is expressed in male reproductive system and urinary system. Orthologous to human SIGIRR (single Ig and TIR domain containing). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in kidney adult (RPKM 26.8), placenta adult (RPKM 18.4) and 20 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 F5; 7 86.35 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (140671088..140680493, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (141091175..141100597, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Regulation of CD18 stability by SIGIRR-modulated ubiquitination: new insights into the relationship between innate immune response and acute lung injury.
Title: Regulation of CD18 stability by SIGIRR-modulated ubiquitination: new insights into the relationship between innate immune response and acute lung injury.
Interleukin-37 promotes colitis-associated carcinogenesis via SIGIRR-mediated cytotoxic T cells dysfunction.
Title: Interleukin-37 promotes colitis-associated carcinogenesis via SIGIRR-mediated cytotoxic T cells dysfunction.
SIGIRR Negatively Regulates IL-36-Driven Psoriasiform Inflammation and Neutrophil Infiltration in the Skin.
Title: SIGIRR Negatively Regulates IL-36-Driven Psoriasiform Inflammation and Neutrophil Infiltration in the Skin.
IL-37 exerts therapeutic effects in experimental autoimmune encephalomyelitis through the receptor complex IL-1R5/IL-1R8.
Title: IL-37 exerts therapeutic effects in experimental autoimmune encephalomyelitis through the receptor complex IL-1R5/IL-1R8.
MiR-340 suppresses CCl4-induced acute liver injury through exerting anti-inflammation targeting Sigirr.
Title: MiR-340 suppresses CCl4-induced acute liver injury through exerting anti-inflammation targeting Sigirr.
Anti-inflammatory mediators ST2 and SIGIRR are induced by diphenyldifluoroketone EF24 in lipopolysaccharide-stimulated dendritic cells.
Title: Anti-inflammatory mediators ST2 and SIGIRR are induced by diphenyldifluoroketone EF24 in lipopolysaccharide-stimulated dendritic cells.
Single immunoglobulin and Tollinterleukin1 receptor domain containing molecule protects against severe acute pancreatitis in vitro by negatively regulating the Tolllike receptor4 signaling pathway: A clinical and experimental study.
Title: Single immunoglobulin and Toll‑interleukin‑1 receptor domain containing molecule protects against severe acute pancreatitis in vitro by negatively regulating the Toll‑like receptor‑4 signaling pathway: A clinical and experimental study.
Stabilization of IL-1R8/Sigirr by USP13 describes a novel anti-inflammatory pathway in diseases that could provide a new strategy to modulate immune activation
Title: The deubiquitinase USP13 stabilizes the anti-inflammatory receptor IL-1R8/Sigirr to suppress lung inflammation.
SIGIRR is a negative regulator of TLR4 signaling in the developing intestine, and its insufficiency results in native intestinal TLR hyper-responsiveness conducive to the development of severe experimental necrotizing enterocolitis in mice
Title: Single-Immunoglobulin Interleukin-1-Related Receptor regulates vulnerability to TLR4-mediated necrotizing enterocolitis in a mouse model.
Here the authors show that hyperactivation of the interleukin 1 pathway, through either ablation of the interleukin 1 receptor 8 (IL-1R8, also known as SIGIRR or Tir8) or activation of IL-1R, leads to up-regulation of the mTOR pathway and increased levels of the epigenetic regulator MeCP2, bringing to disruption of dendritic spine morphology, synaptic plasticity and plasticity-related gene expression.
Title: Lack of IL-1R8 in neurons causes hyperactivation of IL-1 receptor pathway and induces MECP2-dependent synaptic defects.

Submit: New GeneRIF Correction See all GeneRIFs (44)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5)
Gene trapped (1)
Targeted (3) 1 citation

General gene information

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Markers

RH136076 (e-PCR)
- UniSTS:210071

AI644464 (e-PCR)
- UniSTS:179669

Gene Ontology Provided by MGI

Process	Evidence Code	Pubs
involved_in acute-phase response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell surface receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of Toll signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of Toll signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of chemokine production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cytokine-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of interleukin-1-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cell surface	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: single Ig IL-1-related receptor

Names: single Ig IL-1 receptor related protein; single Ig IL-1R-related molecule; single Ig IL-1R-related protein; single immunoglobulin domain-containing IL1R-related protein; toll/interleukin-1 receptor 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001355055.2 → NP_001341984.1 single Ig IL-1-related receptor isoform 1

Status: VALIDATED

Source sequence(s)

AC109272

Consensus CDS

CCDS40179.1

UniProtKB/Swiss-Prot

Q52L48, Q9JLZ8

UniProtKB/TrEMBL

Q3UKS3, Q3V005

Related

ENSMUSP00000147541.2, ENSMUST00000209294.2

Conserved Domains (2) summary

pfam01582
Location:164 → 326

TIR; TIR domain

pfam13927
Location:9 → 101

Ig_3; Immunoglobulin domain
NM_001427142.1 → NP_001414071.1 single Ig IL-1-related receptor isoform 1

Status: VALIDATED

Source sequence(s)

AC109272

UniProtKB/Swiss-Prot

Q52L48, Q9JLZ8

UniProtKB/TrEMBL

Q3UKS3, Q3V005
NM_001427147.1 → NP_001414076.1 single Ig IL-1-related receptor isoform 1

Status: VALIDATED

Source sequence(s)

AC109272

UniProtKB/Swiss-Prot

Q52L48, Q9JLZ8

UniProtKB/TrEMBL

Q3UKS3, Q3V005
NM_001427148.1 → NP_001414077.1 single Ig IL-1-related receptor isoform 1

Status: VALIDATED

Source sequence(s)

AC109272

UniProtKB/Swiss-Prot

Q52L48, Q9JLZ8

UniProtKB/TrEMBL

Q3UKS3, Q3V005
NM_001427149.1 → NP_001414078.1 single Ig IL-1-related receptor isoform 1

Status: VALIDATED

Source sequence(s)

AC109272

UniProtKB/Swiss-Prot

Q52L48, Q9JLZ8

UniProtKB/TrEMBL

Q3UKS3, Q3V005
NM_001427150.1 → NP_001414079.1 single Ig IL-1-related receptor isoform 1

Status: VALIDATED

Source sequence(s)

AC109272

UniProtKB/Swiss-Prot

Q52L48, Q9JLZ8

UniProtKB/TrEMBL

Q3UKS3, Q3V005
NM_001427151.1 → NP_001414080.1 single Ig IL-1-related receptor isoform 2

Status: VALIDATED

Source sequence(s)

AC109272
NM_023059.4 → NP_075546.2 single Ig IL-1-related receptor isoform 1

See identical proteins and their annotated locations for NP_075546.2

Status: VALIDATED

Source sequence(s)

AC109272

Consensus CDS

CCDS40179.1

UniProtKB/Swiss-Prot

Q52L48, Q9JLZ8

UniProtKB/TrEMBL

Q3UKS3, Q3V005

Related

ENSMUSP00000095571.3, ENSMUST00000097958.3

Conserved Domains (2) summary

pfam01582
Location:164 → 326

TIR; TIR domain

pfam13927
Location:9 → 101

Ig_3; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

140671088..140680493 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006536175.5 → XP_006536238.2 single Ig IL-1-related receptor isoform X1

UniProtKB/TrEMBL

Q3V005

Conserved Domains (2) summary

pfam01582
Location:169 → 331

TIR; TIR domain

pfam13927
Location:14 → 106

Ig_3; Immunoglobulin domain
XM_011249842.1 → XP_011248144.1 single Ig IL-1-related receptor isoform X3

Conserved Domains (1) summary

pfam01582
Location:83 → 245

TIR; TIR domain