Rnf122 ring finger protein 122 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rnf122provided by MGI
Official Full Name: ring finger protein 122provided by MGI
Primary source: MGI:MGI:1916117
See related: Ensembl:ENSMUSG00000039328 AllianceGenome:MGI:1916117
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 1110063C11Rik
Summary: Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in several processes, including negative regulation of mitochondrial membrane potential; proteasome-mediated ubiquitin-dependent protein catabolic process; and protein autoubiquitination. Predicted to be located in cytoplasm. Is expressed in cerebral cortex ventricular layer and cortical plate. Orthologous to human RNF122 (ring finger protein 122). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in limb E14.5 (RPKM 11.2), CNS E11.5 (RPKM 10.1) and 23 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 A3; 8 17.97 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (31601855..31623346)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (31111827..31133318)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RNF122 suppresses antiviral type I interferon production by targeting RIG-I caspase activation and recruitment domains to mediate RIG-I degradation.
Title: RNF122 suppresses antiviral type I interferon production by targeting RIG-I CARDs to mediate RIG-I degradation.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in negative regulation of mitochondrial membrane potential	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of mitochondrial membrane potential	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein autoubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein autoubiquitination	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: RING finger protein 122

Names: ring finger protein 122 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001368373.1 → NP_001355302.1 RING finger protein 122 isoform 1

Status: VALIDATED

Source sequence(s)

AC109163
NM_001368374.1 → NP_001355303.1 RING finger protein 122 isoform 2

Status: VALIDATED

Source sequence(s)

AC109163
NM_001368375.1 → NP_001355304.1 RING finger protein 122 isoform 3

Status: VALIDATED

Source sequence(s)

AC109163

Consensus CDS

CCDS90381.1

UniProtKB/Swiss-Prot

Q80VA7, Q8BGD3, Q8BP31

Related

ENSMUSP00000150893.2, ENSMUST00000217278.2

Conserved Domains (1) summary

cd16469
Location:91 → 137

RING-H2_RNF24_like; RING finger, H2 subclass, found in RING finger proteins RNF24, RNF122, and similar proteins
NM_175136.3 → NP_780345.1 RING finger protein 122 isoform 4

See identical proteins and their annotated locations for NP_780345.1

Status: VALIDATED

Source sequence(s)

AC109163

Consensus CDS

CCDS22220.1

UniProtKB/TrEMBL

A0A0R4J0G8

Related

ENSMUSP00000040478.8, ENSMUST00000046941.8

Conserved Domains (1) summary

cd16469
Location:91 → 136

RING-H2_RNF24_like; RING finger, H2 subclass, found in RING finger proteins RNF24, RNF122, and similar proteins