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    Stpg4 sperm tail PG rich repeat containing 4 [ Mus musculus (house mouse) ]

    Gene ID: 75467, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Stpg4provided by MGI
    Official Full Name
    sperm tail PG rich repeat containing 4provided by MGI
    Primary source
    MGI:MGI:1922717
    See related
    Ensembl:ENSMUSG00000036557 AllianceGenome:MGI:1922717
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    GSE; 1700011E24Rik
    Summary
    Enables chromatin binding activity and histone binding activity. Acts upstream of with a positive effect on epigenetic programing of male pronucleus. Acts upstream of or within pyrimidine-containing compound catabolic process. Located in cytoplasm and nucleus. Orthologous to human STPG4 (sperm-tail PG-rich repeat containing 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward testis adult (RPKM 34.4) See more
    Orthologs
    human all
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    Genomic context

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    See Stpg4 in Genome Data Viewer
    Location:
    17 E4; 17 57.38 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (87696998..87735526, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (87389570..87428081, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene tetratricopeptide repeat domain 7 Neighboring gene predicted gene, 52284 Neighboring gene STARR-positive B cell enhancer ABC_E11653 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:87743694-87743847 Neighboring gene RIKEN cDNA 0610012D04 gene Neighboring gene STARR-seq mESC enhancer starr_43504 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:87846074-87846261 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:87846398-87846581 Neighboring gene calmodulin 2 Neighboring gene predicted gene, 26005

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. GSE is a maternal factor involved in active DNA demethylation in zygotes. Hatanaka Y, et al. PLoS One, 2013. PMID 23560077, Free PMC Article
    2. Expression and subcellular localization of GSE protein in germ cells and preimplantation embryos. Mizuno S, et al. J Reprod Dev, 2006 Jun. PMID 16571911
    3. Histone H3 Methylated at Arginine 17 Is Essential for Reprogramming the Paternal Genome in Zygotes. Hatanaka Y, et al. Cell Rep, 2017 Sep 19. PMID 28930672
    4. Genome engineering uncovers 54 evolutionarily conserved and testis-enriched genes that are not required for male fertility in mice. Miyata H, et al. Proc Natl Acad Sci U S A, 2016 Jul 12. PMID 27357688, Free PMC Article
    5. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. GSE is a maternal factor involved in active DNA demethylation in zygotes.
      Title: GSE is a maternal factor involved in active DNA demethylation in zygotes.
    2. findings suggest that GSE protein may play a role in the establishment of nuclear totipotency and may be associated with early lineage specification.
      Title: Expression and subcellular localization of GSE protein in germ cells and preimplantation embryos.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in epigenetic programing of male pronucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_positive_effect epigenetic programing of male pronucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in epigenetic programing of male pronucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within pyrimidine-containing compound catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in female germ cell nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in female pronucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in female pronucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in germinal vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in germinal vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in male germ cell nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in male pronucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in male pronucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein STPG4
    Names
    gonad-specific expression gene protein
    sperm-tail PG-rich repeat-containing protein 4
    uncharacterized protein C2orf61 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_029298.1 → NP_083574.1  protein STPG4

      See identical proteins and their annotated locations for NP_083574.1

      Status: VALIDATED

      Source sequence(s)
      AK005861, BE456690, BY096438
      Consensus CDS
      CCDS50206.1
      UniProtKB/Swiss-Prot
      Q9DAG5
      UniProtKB/TrEMBL
      A0A087WRD7
      Related
      ENSMUSP00000044250.3, ENSMUST00000040609.9

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      87696998..87735526 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006525072.4 → XP_006525135.1  protein STPG4 isoform X5

    2. XM_017317707.3 → XP_017173196.1  protein STPG4 isoform X3

    3. XM_006525071.5 → XP_006525134.1  protein STPG4 isoform X4

    4. XM_006525070.3 → XP_006525133.1  protein STPG4 isoform X1

    5. XM_011246699.3 → XP_011245001.1  protein STPG4 isoform X6

    6. XM_011246698.3 → XP_011245000.1  protein STPG4 isoform X2

    RNA

    1. XR_001782126.3 RNA Sequence

    2. XR_385380.5 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9DAG5.1 GenPept UniProtKB/Swiss-Prot:Q9DAG5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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