Pex3 Peroxin 3 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Pex3provided by FlyBase
Official Full Name: Peroxin 3provided by FlyBase
Primary source: FLYBASE:FBgn0036484
Locus tag: Dmel_CG6859
See related: AllianceGenome:FB:FBgn0036484
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG6859; DmelPex3; Dmel\CG6859; pex3; PEX3
Summary: Predicted to enable protein-macromolecule adaptor activity. Involved in fatty acid elongation; peroxisome organization; and positive regulation of ceramide biosynthetic process. Located in endoplasmic reticulum and peroxisome. Is expressed in adult head; embryonic cortex; embryonic/larval midgut; and organism. Used to study Zellweger syndrome. Human ortholog(s) of this gene implicated in Peroxisome biogenesis disorder 10B and peroxisome biogenesis disorder 10A. Orthologous to human PEX3 (peroxisomal biogenesis factor 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (15144355..15146379)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (15137455..15139479)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables protein-macromolecule adaptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in fatty acid elongation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peroxisome organization	IEA Inferred from Electronic Annotation more info
involved_in peroxisome organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peroxisome organization	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in positive regulation of ceramide biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein import into peroxisome membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein import into peroxisome membrane	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
is_active_in peroxisomal membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in peroxisomal membrane	IEA Inferred from Electronic Annotation more info
located_in peroxisomal membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in peroxisome	IDA Inferred from Direct Assay more info	PubMed
located_in peroxisome	ISS Inferred from Sequence or Structural Similarity more info	PubMed