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    Apoltp Apolipoprotein lipid transfer particle [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34283, updated on 17-Dec-2024

    Summary

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    Official Symbol
    Apoltpprovided by FlyBase
    Official Full Name
    Apolipoprotein lipid transfer particleprovided by FlyBase
    Primary source
    FLYBASE:FBgn0032136
    Locus tag
    Dmel_CG15828
    See related
    AllianceGenome:FB:FBgn0032136
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    apoltp; apoLTP; ApoLTP; ApoLTPI; ApoLTPII; CG15828; CT39214; Dmel\CG15828; ltp; Ltp; LTP
    Summary
    Enables lipid transporter activity and lipoprotein particle receptor binding activity. Involved in several processes, including acylglycerol transport; sterol transport; and transport across blood-brain barrier. Located in basal part of cell; extracellular space; and plasma membrane. Is expressed in several structures, including adult head; epithelium; fat body; germline cell; and hemolymph. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Apoltp in Genome Data Viewer
    Location:
    30C2-30C2; 2-36 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (9634179..9656026)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (9634179..9656026)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Glucuronyltransferase S Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR46208

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Shuttling between species for pathways of lifespan regulation: a central role for the vitellogenin gene family? Brandt BW, et al. Bioessays, 2005 Mar. PMID 15714554
    2. The heterogeneous nuclear ribonucleoprotein (hnRNP) glorund functions in the Drosophila fat body to regulate lipid storage and transport. Kolasa AM, et al. Biochem Biophys Rep, 2021 Mar. PMID 33537463, Free PMC Article
    3. The Exchangeable Apolipoprotein Nplp2 Sustains Lipid Flow and Heat Acclimation in Drosophila. Rommelaere S, et al. Cell Rep, 2019 Apr 16. PMID 30995484
    4. Microsomal triacylglycerol transfer protein (MTP) is required to expand tracheal lumen in Drosophila in a cell-autonomous manner. Baer MM, et al. J Cell Sci, 2012 Dec 15. PMID 23132924
    5. Endocrine remodelling of the adult intestine sustains reproduction in Drosophila. Reiff T, et al. Elife, 2015 Jul 28. PMID 26216039, Free PMC Article

    See all (64) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables lipid transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables lipid transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lipid transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables lipoprotein particle receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in acylglycerol transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in lipid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of lipid transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sterol transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transport across blood-brain barrier IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in basal part of cell IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    apolipoprotein lipid transfer particle
    Names
    Apoltp-PC
    CG15828-PC
    lipid transfer particle

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      9634179..9656026
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_205948.3 → NP_995670.2  apolipoprotein lipid transfer particle [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_995670.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KTG2
      Conserved Domains (5) summary
      smart00638
      Location:49 → 633
      LPD_N; Lipoprotein N-terminal Domain
      pfam06448
      Location:1029 → 1122
      DUF1081; Domain of Unknown Function (DUF1081)
      pfam08742
      Location:3951 → 4014
      C8; C8 domain
      pfam09172
      Location:665 → 1012
      DUF1943; Domain of unknown function (DUF1943)
      cl02516
      Location:3741 → 3908
      VWD; von Willebrand factor type D domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7KTG2 Q7KTG2
    Q8MRJ0 Q8MRJ0

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