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    Sytalpha Synaptotagmin alpha [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35068, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Sytalphaprovided by FlyBase
    Official Full Name
    Synaptotagmin alphaprovided by FlyBase
    Primary source
    FLYBASE:FBgn0261089
    Locus tag
    Dmel_CG5559
    See related
    AllianceGenome:FB:FBgn0261089
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG5559; Dmel\CG5559; dsytalpha; Syt alpha; SYT-alpha; Syt3; SYT3; sytalpha
    Summary
    Predicted to enable SNARE binding activity; calcium ion sensor activity; and calcium-dependent phospholipid binding activity. Predicted to be involved in calcium-dependent activation of synaptic vesicle fusion; regulation of calcium ion-dependent exocytosis; and regulation of synaptic vesicle exocytosis. Located in plasma membrane. Is expressed in adult head. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Sytalpha in Genome Data Viewer
    Location:
    36D1-36D1; 2-53 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (17592260..17604387)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (17592260..17604387)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44411 Neighboring gene long non-coding RNA:CR44410 Neighboring gene Olig family Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44412 Neighboring gene long non-coding RNA:CR44413

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A neuropeptidergic circuit gates selective escape behavior of Drosophila larvae. Imambocus BN, et al. Curr Biol, 2022 Jan 10. PMID 34798050
    2. Peptidergic cell-specific synaptotagmins in Drosophila: localization to dense-core granules and regulation by the bHLH protein DIMMED. Park D, et al. J Neurosci, 2014 Sep 24. PMID 25253864, Free PMC Article
    3. Regulation of locomotion and motoneuron trajectory selection and targeting by the Drosophila homolog of Olig family transcription factors. Oyallon J, et al. Dev Biol, 2012 Sep 15. PMID 22796650, Free PMC Article
    4. Function of Drosophila Synaptotagmins in membrane trafficking at synapses. Quiñones-Frías MC, et al. Cell Mol Life Sci, 2021 May. PMID 33619613, Free PMC Article
    5. Genetic and molecular analysis of the synaptotagmin family. Adolfsen B, et al. Cell Mol Life Sci, 2001 Mar. PMID 11315187, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables SNARE binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium ion sensor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium-dependent phospholipid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium-dependent phospholipid binding NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in calcium-dependent activation of synaptic vesicle fusion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in neurotransmitter secretion NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of calcium ion-dependent exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of synaptic vesicle exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vesicle-mediated transport NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in axon IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in dense core granule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in exocytic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane ISM
    Inferred from Sequence Model
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in synaptic vesicle membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    synaptotagmin alpha
    Names
    CG5559-PA
    CG5559-PB
    CG5559-PC
    CG5559-PD
    Syt3
    Sytalpha-PA
    Sytalpha-PB
    Sytalpha-PC
    Sytalpha-PD
    sytalpha

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      17592260..17604387
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001201903.1 → NP_001188832.1  synaptotagmin alpha, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188832.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C0HDP4
      Conserved Domains (2) summary
      cd00276
      Location:352 → 488
      C2B_Synaptotagmin; C2 domain second repeat present in Synaptotagmin
      cd08387
      Location:218 → 341
      C2A_Synaptotagmin-8; C2A domain first repeat present in Synaptotagmin 8

    2. NM_136009.2 → NP_609853.1  synaptotagmin alpha, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609853.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9I7M6
      Related
      FBpp0080540
      Conserved Domains (2) summary
      cd00276
      Location:342 → 478
      C2B_Synaptotagmin; C2 domain second repeat present in Synaptotagmin
      cd08387
      Location:208 → 331
      C2A_Synaptotagmin-8; C2A domain first repeat present in Synaptotagmin 8

    3. NM_001299090.1 → NP_001286019.1  synaptotagmin alpha, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286019.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9I7M6
      Conserved Domains (2) summary
      cd00276
      Location:342 → 478
      C2B_Synaptotagmin; C2 domain second repeat present in Synaptotagmin
      cd08387
      Location:208 → 331
      C2A_Synaptotagmin-8; C2A domain first repeat present in Synaptotagmin 8

    4. NM_001201904.1 → NP_001188833.1  synaptotagmin alpha, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188833.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9I7M6
      Conserved Domains (2) summary
      cd00276
      Location:342 → 478
      C2B_Synaptotagmin; C2 domain second repeat present in Synaptotagmin
      cd08387
      Location:208 → 331
      C2A_Synaptotagmin-8; C2A domain first repeat present in Synaptotagmin 8
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    C0HDP4 C0HDP4
    Q9I7M6 Q9I7M6

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