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    Ctr1A Copper transporter 1A [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31601, updated on 17-Dec-2024

    Summary

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    Official Symbol
    Ctr1Aprovided by FlyBase
    Official Full Name
    Copper transporter 1Aprovided by FlyBase
    Primary source
    FLYBASE:FBgn0062413
    Locus tag
    Dmel_CG3977
    See related
    AllianceGenome:FB:FBgn0062413
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:RH42635; CG3977; ctr1A; DmCtr1A; Dmel\CG3977
    Summary
    Enables copper ion transmembrane transporter activity. Involved in copper ion transport; intracellular copper ion homeostasis; and regulation of heart rate. Located in plasma membrane. Is expressed in adult head. Used to study cardiomyopathy. Orthologous to human SLC31A1 (solute carrier family 31 member 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Ctr1A in Genome Data Viewer
    Location:
    6C4-6C4; 1-18 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (6661647..6668258)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (6555680..6562291)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Cdc7 kinase Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Minichromosome maintenance 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Drosophila copper transporter Ctr1C functions in male fertility. Steiger D, et al. J Biol Chem, 2010 May 28. PMID 20351114, Free PMC Article
    2. Control of Alzheimer's amyloid beta toxicity by the high molecular weight immunophilin FKBP52 and copper homeostasis in Drosophila. Sanokawa-Akakura R, et al. PLoS One, 2010 Jan 13. PMID 20084280, Free PMC Article
    3. Cardiac copper deficiency activates a systemic signaling mechanism that communicates with the copper acquisition and storage organs. Kim BE, et al. Cell Metab, 2010 May 5. PMID 20444417, Free PMC Article
    4. Detection of genetically altered copper levels in Drosophila tissues by synchrotron x-ray fluorescence microscopy. Lye JC, et al. PLoS One, 2011. PMID 22053217, Free PMC Article
    5. Human copper transporter Ctr1 is functional in Drosophila, revealing a high degree of conservation between mammals and insects. Hua H, et al. J Biol Inorg Chem, 2010 Jan. PMID 19856191

    See all (70) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables copper ion transmembrane transporter activity IC
    Inferred by Curator
    more info
    		 PubMed 
    enables copper ion transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables copper ion transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables copper ion transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in copper ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in copper ion transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in copper ion transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular copper ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in plasma membrane copper ion transport IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in regulation of heart rate IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    copper transporter 1A
    Names
    CG3977-PA
    CG3977-PB
    CG3977-PC
    CG3977-PD
    Ctr1A-PA
    Ctr1A-PB
    Ctr1A-PC
    Ctr1A-PD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      6661647..6668258
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_132108.3 → NP_572336.2  copper transporter 1A, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572336.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MQM5, Q9W3X9
      Related
      FBpp0070912
      Conserved Domains (1) summary
      pfam04145
      Location:79 → 216
      Ctr; Ctr copper transporter family

    2. NM_001258622.2 → NP_001245551.1  copper transporter 1A, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245551.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MQM5, Q9W3X9
      Conserved Domains (1) summary
      pfam04145
      Location:79 → 216
      Ctr; Ctr copper transporter family

    3. NM_001258623.2 → NP_001245552.1  copper transporter 1A, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245552.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9NE97, Q8MQM5
      Conserved Domains (1) summary
      pfam04145
      Location:79 → 226
      Ctr; Ctr copper transporter family

    4. NM_001258624.1 → NP_001245553.1  copper transporter 1A, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245553.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9NE97, Q8MQM5
      Conserved Domains (1) summary
      pfam04145
      Location:79 → 226
      Ctr; Ctr copper transporter family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9NE97 M9NE97
    Q8MQM5 Q8MQM5
    Q9W3X9 Q9W3X9

    Gene LinkOut

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