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    Pank2 pantothenate kinase 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 296167, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Pank2provided by RGD
    Official Full Name
    pantothenate kinase 2provided by RGD
    Primary source
    RGD:1305169
    See related
    EnsemblRapid:ENSRNOG00000025286 AllianceGenome:RGD:1305169
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable pantothenate kinase activity. Predicted to be involved in angiogenesis; coenzyme A biosynthetic process; and regulation of lipid metabolic process. Predicted to act upstream of or within several processes, including aerobic respiration; regulation of mitochondrial membrane potential; and spermatid development. Predicted to be located in mitochondrion. Predicted to be active in cytosol; mitochondrial intermembrane space; and nucleus. Human ortholog(s) of this gene implicated in pantothenate kinase-associated neurodegeneration. Orthologous to human PANK2 (pantothenate kinase 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Thymus (RPKM 147.1), Lung (RPKM 132.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Pank2 in Genome Data Viewer
    Location:
    3q36
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (138936448..138974196)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (118483382..118519551)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (123807911..123841797)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene adaptor related protein complex 5 subunit sigma 1 Neighboring gene mitochondrial antiviral signaling protein Neighboring gene uncharacterized LOC134486155 Neighboring gene microRNA 103a-2 Neighboring gene ring finger protein 24 Neighboring gene uncharacterized LOC102550049 Neighboring gene family with sequence similarity 98, member B, pseudogene 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Pantothenate kinase-associated neurodegeneration: altered mitochondria membrane potential and defective respiration in Pank2 knock-out mouse model. Brunetti D, et al. Hum Mol Genet, 2012 Dec 15. PMID 22983956, Free PMC Article
    2. Metabolic consequences of mitochondrial coenzyme A deficiency in patients with PANK2 mutations. Leoni V, et al. Mol Genet Metab, 2012 Mar. PMID 22221393, Free PMC Article
    3. Deficiency of pantothenate kinase 2 (Pank2) in mice leads to retinal degeneration and azoospermia. Kuo YM, et al. Hum Mol Genet, 2005 Jan 1. PMID 15525657, Free PMC Article
    4. Localization and regulation of mouse pantothenate kinase 2. Leonardi R, et al. FEBS Lett, 2007 Oct 2. PMID 17825826, Free PMC Article
    5. Germline deletion of pantothenate kinases 1 and 2 reveals the key roles for CoA in postnatal metabolism. Garcia M, et al. PLoS One, 2012. PMID 22815849, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pantothenate kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables pantothenate kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within aerobic respiration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in angiogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in coenzyme A biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within coenzyme A biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in coenzyme A biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within mitochondrion organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of bile acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of fatty acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of mitochondrial membrane potential ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of triglyceride metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within spermatid development ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in mitochondrial intermembrane space ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial intermembrane space ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    pantothenate kinase 2, mitochondrial
    Names
    pantothenate kinase 2 (Hallervorden-Spatz syndrome)
    NP_001099983.1
    XP_017447073.1
    XP_038960511.1
    XP_038960512.1
    XP_038960514.1
    XP_038960515.1
    XP_038960516.1
    XP_063139403.1
    XP_063139404.1
    XP_063139405.1
    XP_063139407.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106513.2 → NP_001099983.1  pantothenate kinase 2, mitochondrial

      See identical proteins and their annotated locations for NP_001099983.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A6HQD5, F1LT70
      Related
      ENSRNOP00000036035.6, ENSRNOT00000033554.7
      Conserved Domains (1) summary
      pfam03630
      Location:87 → 435
      Fumble

    RNA

    1. NR_190881.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003

    2. NR_190882.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003

    3. NR_190883.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003

    4. NR_190884.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      138936448..138974196
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039104588.2 → XP_038960516.1  pantothenate kinase 2, mitochondrial isoform X9

      Conserved Domains (1) summary
      cl17037
      Location:117 → 236
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

    2. XM_039104586.2 → XP_038960514.1  pantothenate kinase 2, mitochondrial isoform X7

      Conserved Domains (1) summary
      cl17037
      Location:117 → 280
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

    3. XM_039104583.2 → XP_038960511.1  pantothenate kinase 2, mitochondrial isoform X2

      Conserved Domains (1) summary
      pfam03630
      Location:117 → 474
      Fumble

    4. XM_063283333.1 → XP_063139403.1  pantothenate kinase 2, mitochondrial isoform X1

    5. XM_017591584.3 → XP_017447073.1  pantothenate kinase 2, mitochondrial isoform X3

    6. XM_039104584.2 → XP_038960512.1  pantothenate kinase 2, mitochondrial isoform X5

      Conserved Domains (1) summary
      pfam03630
      Location:87 → 444
      Fumble

    7. XM_039104587.2 → XP_038960515.1  pantothenate kinase 2, mitochondrial isoform X8

      Conserved Domains (1) summary
      cl17037
      Location:87 → 250
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

    8. XM_063283334.1 → XP_063139404.1  pantothenate kinase 2, mitochondrial isoform X4

    9. XM_063283337.1 → XP_063139407.1  pantothenate kinase 2, mitochondrial isoform X10

    10. XM_063283335.1 → XP_063139405.1  pantothenate kinase 2, mitochondrial isoform X6

    RNA

    1. XR_010064584.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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