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    Osbpl1a oxysterol binding protein-like 1A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 259221, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Osbpl1aprovided by RGD
    Official Full Name
    oxysterol binding protein-like 1Aprovided by RGD
    Primary source
    RGD:628888
    See related
    EnsemblRapid:ENSRNOG00000054058 AllianceGenome:RGD:628888
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable cholesterol binding activity. Predicted to be involved in lipid transport. Predicted to be located in late endosome and organelle membrane contact site. Predicted to be active in cytosol; perinuclear endoplasmic reticulum; and plasma membrane. Orthologous to human OSBPL1A (oxysterol binding protein like 1A). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 361.3), Kidney (RPKM 326.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Osbpl1a in Genome Data Viewer
    Location:
    18p13
    Exon count:
    36
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (4178734..4383511, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (3904006..4094635, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (4097011..4294136, complement)

    Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene tetratricopeptide repeat domain 39C Neighboring gene uncharacterized LOC134482904 Neighboring gene calcium binding tyrosine phosphorylation regulated Neighboring gene uncharacterized LOC102546723 Neighboring gene oxysterol binding protein-like 1A like Neighboring gene non-histone chromosomal protein HMG-17 pseudogene Neighboring gene impact RWD domain protein Neighboring gene histamine receptor H4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Androgen-regulated expression of a novel member of the aldo-keto reductase superfamily in regrowing rat prostate. Nishi N, et al. Endocrinology, 2000 Sep. PMID 10965890
    2. The oxysterol-binding protein homologue ORP1L interacts with Rab7 and alters functional properties of late endocytic compartments. Johansson M, et al. Mol Biol Cell, 2005 Dec. PMID 16176980, Free PMC Article
    3. Structural basis of FFAT motif-mediated ER targeting. Kaiser SE, et al. Structure, 2005 Jul. PMID 16004875
    4. Novel members of the human oxysterol-binding protein family bind phospholipids and regulate vesicle transport. Xu Y, et al. J Biol Chem, 2001 May 25. PMID 11279184
    5. The mammalian oxysterol-binding protein-related proteins (ORPs) bind 25-hydroxycholesterol in an evolutionarily conserved pocket. Suchanek M, et al. Biochem J, 2007 Aug 1. PMID 17428193, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cholesterol binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cholesterol binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in lipid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in late endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in late endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in late endosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in organelle membrane contact site IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in organelle membrane contact site ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in perinuclear endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    oxysterol-binding protein-related protein 1
    Names
    ORP-1
    OSBP-related protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172023.1 → NP_742020.1  oxysterol-binding protein-related protein 1

      See identical proteins and their annotated locations for NP_742020.1

      Status: PROVISIONAL

      Source sequence(s)
      AB089316
      UniProtKB/Swiss-Prot
      Q8K4M9
      UniProtKB/TrEMBL
      A0A0G2K327
      Related
      ENSRNOP00000072477.2, ENSRNOT00000091909.3
      Conserved Domains (7) summary
      cd00204
      Location:43 → 196
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd13285
      Location:229 → 352
      PH_ORP1; Human Oxysterol binding protein related protein 1 Pleckstrin homology (PH) domain
      pfam00169
      Location:239 → 334
      PH; PH domain
      pfam01237
      Location:548 → 934
      Oxysterol_BP; Oxysterol-binding protein
      pfam12796
      Location:10 → 111
      Ank_2; Ankyrin repeats (3 copies)
      pfam13857
      Location:160 → 216
      Ank_5; Ankyrin repeats (many copies)
      sd00045
      Location:43 → 78
      ANK; ANK repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086036.1 Reference GRCr8

      Range
      4178734..4383511 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063277125.1 → XP_063133195.1  oxysterol-binding protein-related protein 1 isoform X1

    2. XM_063277127.1 → XP_063133197.1  oxysterol-binding protein-related protein 1 isoform X2

      UniProtKB/TrEMBL
      A6KLS5

    3. XM_063277126.1 → XP_063133196.1  oxysterol-binding protein-related protein 1 isoform X2

      UniProtKB/TrEMBL
      A6KLS5

    4. XM_063277128.1 → XP_063133198.1  oxysterol-binding protein-related protein 1 isoform X2

      UniProtKB/TrEMBL
      A6KLS5

    5. XM_039096597.2 → XP_038952525.1  oxysterol-binding protein-related protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K327
      Conserved Domains (5) summary
      COG0666
      Location:38 → 208
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      cd13285
      Location:230 → 353
      PH_ORP1; Human Oxysterol binding protein related protein 1 Pleckstrin homology (PH) domain
      sd00045
      Location:43 → 78
      ANK; ANK repeat [structural motif]
      pfam01237
      Location:549 → 941
      Oxysterol_BP; Oxysterol-binding protein
      pfam12796
      Location:10 → 111
      Ank_2; Ankyrin repeats (3 copies)

    6. XM_039096596.2 → XP_038952524.1  oxysterol-binding protein-related protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K327
      Conserved Domains (5) summary
      COG0666
      Location:38 → 208
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      cd13285
      Location:230 → 353
      PH_ORP1; Human Oxysterol binding protein related protein 1 Pleckstrin homology (PH) domain
      sd00045
      Location:43 → 78
      ANK; ANK repeat [structural motif]
      pfam01237
      Location:549 → 941
      Oxysterol_BP; Oxysterol-binding protein
      pfam12796
      Location:10 → 111
      Ank_2; Ankyrin repeats (3 copies)

    7. XM_039096598.1 → XP_038952526.1  oxysterol-binding protein-related protein 1 isoform X3

      UniProtKB/TrEMBL
      A0A0G2K327
      Related
      ENSRNOP00000109377.1, ENSRNOT00000162073.1
      Conserved Domains (4) summary
      cd13285
      Location:139 → 262
      PH_ORP1; Human Oxysterol binding protein related protein 1 Pleckstrin homology (PH) domain
      sd00045
      Location:43 → 82
      ANK; ANK repeat [structural motif]
      pfam01237
      Location:458 → 850
      Oxysterol_BP; Oxysterol-binding protein
      pfam12796
      Location:10 → 115
      Ank_2; Ankyrin repeats (3 copies)

    8. XM_063277129.1 → XP_063133199.1  oxysterol-binding protein-related protein 1 isoform X4

    9. XM_039096602.1 → XP_038952530.1  oxysterol-binding protein-related protein 1 isoform X8

      UniProtKB/TrEMBL
      A0A8I6GFS2
      Related
      ENSRNOP00000087195.1, ENSRNOT00000119742.2
      Conserved Domains (1) summary
      pfam01237
      Location:125 → 517
      Oxysterol_BP; Oxysterol-binding protein

    10. XM_063277130.1 → XP_063133200.1  oxysterol-binding protein-related protein 1 isoform X5

    11. XM_039096601.2 → XP_038952529.1  oxysterol-binding protein-related protein 1 isoform X7

      UniProtKB/TrEMBL
      A0A8I6GFS2
      Conserved Domains (1) summary
      pfam01237
      Location:166 → 558
      Oxysterol_BP; Oxysterol-binding protein

    12. XM_039096603.2 → XP_038952531.1  oxysterol-binding protein-related protein 1 isoform X8

      UniProtKB/TrEMBL
      A0A8I6GFS2
      Conserved Domains (1) summary
      pfam01237
      Location:125 → 517
      Oxysterol_BP; Oxysterol-binding protein

    13. XM_063277132.1 → XP_063133202.1  oxysterol-binding protein-related protein 1 isoform X6

    14. XM_063277131.1 → XP_063133201.1  oxysterol-binding protein-related protein 1 isoform X5

    15. XM_039096606.2 → XP_038952534.1  oxysterol-binding protein-related protein 1 isoform X9

      UniProtKB/TrEMBL
      A0A8I6GFS2, A6KLS6
      Conserved Domains (1) summary
      pfam01237
      Location:35 → 427
      Oxysterol_BP; Oxysterol-binding protein

    16. XM_039096605.2 → XP_038952533.1  oxysterol-binding protein-related protein 1 isoform X9

      UniProtKB/TrEMBL
      A0A8I6GFS2, A6KLS6
      Conserved Domains (1) summary
      pfam01237
      Location:35 → 427
      Oxysterol_BP; Oxysterol-binding protein

    17. XM_063277133.1 → XP_063133203.1  oxysterol-binding protein-related protein 1 isoform X10

      UniProtKB/TrEMBL
      A6KLS7

    RNA

    1. XR_010059548.1 RNA Sequence

    2. XR_010059549.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8K4M9.1 GenPept UniProtKB/Swiss-Prot:Q8K4M9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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