Pecam1 platelet and endothelial cell adhesion molecule 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Pecam1provided by RGD
Official Full Name: platelet and endothelial cell adhesion molecule 1provided by RGD
Primary source: RGD:61927
See related: EnsemblRapid:ENSRNOG00000066008 AllianceGenome:RGD:61927
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: CD31; Pecam
Summary: Enables protein phosphatase binding activity. Involved in several processes, including cellular response to type II interferon; negative regulation of GTPase activity; and negative regulation of actin filament polymerization. Located in cell surface and ruffle. Used to study pulmonary hypertension. Biomarker of bacterial pneumonia; orchitis; and osteoarthritis. Human ortholog(s) of this gene implicated in coronary artery disease; coronary stenosis; myocardial infarction; neuroblastoma; and psoriatic arthritis. Orthologous to human PECAM1 (platelet and endothelial cell adhesion molecule 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Lung (RPKM 947.0), Heart (RPKM 570.7) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q32.1

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (92090263..92152002, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (91590521..91652279, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (94850971..94913202, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

In the Rat Hippocampus, Pilocarpine-Induced Status Epilepticus Is Associated with Reactive Glia and Concomitant Increased Expression of CD31, PDGFRbeta, and Collagen IV in Endothelial Cells and Pericytes of the Blood-Brain Barrier.
Title: In the Rat Hippocampus, Pilocarpine-Induced Status Epilepticus Is Associated with Reactive Glia and Concomitant Increased Expression of CD31, PDGFRβ, and Collagen IV in Endothelial Cells and Pericytes of the Blood-Brain Barrier.
Hyperglycemia-induced ubiquitination and degradation of beta-catenin with the loss of platelet endothelial cell adhesion molecule-1 in retinal endothelial cells.
Title: Hyperglycemia-induced ubiquitination and degradation of β-catenin with the loss of platelet endothelial cell adhesion molecule-1 in retinal endothelial cells.
Desferoxamine protects against glucocorticoid-induced osteonecrosis of the femoral head via activating HIF-1alpha expression.
Title: Desferoxamine protects against glucocorticoid-induced osteonecrosis of the femoral head via activating HIF-1α expression.
Circulating PECAM-1 is a promising biomarker for the detection and monitoring of ventilator-induced lung injury.
Title: Soluble platelet-endothelial cell adhesion molecule-1, a biomarker of ventilator-induced lung injury.
Shock wave therapy leads to mobilization of endogenous CD31/CD34-positive endothelial cells.
Title: Shock wave treatment induces angiogenesis and mobilizes endogenous CD31/CD34-positive endothelial cells in a hindlimb ischemia model: implications for angiogenesis and vasculogenesis.
connection of NO/IL-10/PECAM-1 during in vivo inflammatory conditions elicited by LPS has been shown
Title: Nitric oxide modulates lipopolysaccharide-induced endothelial platelet endothelial cell adhesion molecule expression via interleukin-10.
Rg1 could increase the expression of HIF1-alpha and CD31 in myocardium and stimulate angiogenesis.
Title: Effect and mechanism of panaxoside Rg1 on neovascularization in myocardial infarction rats.
These results show that NO, produced at physiological levels, controls expression of constitutive adhesion molecules L-selectin and PECAM-1 in cell membranes by different mechanisms of action.
Title: In vivo blockade of Ca(+2)-dependent nitric oxide synthases impairs expressions of L-selectin and PECAM-1.
expression pattern of PECAM & VE-cadherin at endothelial cell junctions in adult initial lymphatic network; results suggest that primary valves are associated with discontinuous expression of endothelial junction molecules
Title: Discontinuous expression of endothelial cell adhesion molecules along initial lymphatic vessels in mesentery: the primary valve structure.
PECAM-1 expression on PMNs is in a converse way between pancreatic microcirculation and peripheral circulation in acute edematous pancreatitis
Title: Expression of platelet endothelial cell adhesion molecule-1 between pancreatic microcirculation and peripheral circulation in rats with acute edematous pancreatitis.

Submit: New GeneRIF Correction See all GeneRIFs (11)

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables protein homodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein phosphatase binding	IPI Inferred from Physical Interaction more info	PubMed
enables transmembrane signaling receptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within Rho protein signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in bicellular tight junction assembly	IEA Inferred from Electronic Annotation more info
involved_in bicellular tight junction assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in cell surface receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in cell-cell adhesion via plasma-membrane adhesion molecules	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-cell adhesion via plasma-membrane adhesion molecules	ISO Inferred from Sequence Orthology more info
involved_in cellular response to organic cyclic compound	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to transforming growth factor beta stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to type II interferon	IEP Inferred from Expression Pattern more info	PubMed
involved_in diapedesis	IEA Inferred from Electronic Annotation more info
involved_in diapedesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within endothelial cell migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within endothelial cell morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within endothelial cell-matrix adhesion	ISO Inferred from Sequence Orthology more info
involved_in establishment of endothelial barrier	IEA Inferred from Electronic Annotation more info
involved_in establishment of endothelial barrier	ISO Inferred from Sequence Orthology more info
involved_in glomerular endothelium development	IEA Inferred from Electronic Annotation more info
involved_in glomerular endothelium development	ISO Inferred from Sequence Orthology more info
involved_in homophilic cell adhesion via plasma membrane adhesion molecules	IEA Inferred from Electronic Annotation more info
involved_in homophilic cell adhesion via plasma membrane adhesion molecules	ISO Inferred from Sequence Orthology more info
involved_in immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in leukocyte cell-cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in leukocyte cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in monocyte extravasation	IEA Inferred from Electronic Annotation more info
involved_in monocyte extravasation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of GTPase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of actin filament polymerization	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of peptidyl-tyrosine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in neutrophil extravasation	IEA Inferred from Electronic Annotation more info
involved_in neutrophil extravasation	ISO Inferred from Sequence Orthology more info
involved_in phagocytosis	IEA Inferred from Electronic Annotation more info
involved_in phagocytosis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell migration	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cellular extravasation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of leukocyte migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of peptidyl-tyrosine phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of peptidyl-tyrosine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein localization to cell-cell junction	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein localization to cell-cell junction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of tyrosine phosphorylation of STAT protein	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of cell migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within wound healing	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell periphery	ISO Inferred from Sequence Orthology more info
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cell-cell contact zone	ISO Inferred from Sequence Orthology more info
located_in cell-cell junction	IEA Inferred from Electronic Annotation more info
located_in cell-cell junction	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in extracellular space	IEA Inferred from Electronic Annotation more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in membrane raft	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
located_in ruffle	IDA Inferred from Direct Assay more info	PubMed
located_in smooth muscle contractile fiber	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: platelet endothelial cell adhesion molecule

Names: PECAM-1; platelet/endothelial cell adhesion molecule 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031591.3 → NP_113779.1 platelet endothelial cell adhesion molecule precursor

See identical proteins and their annotated locations for NP_113779.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000010

UniProtKB/Swiss-Prot

P97635, Q3SWT0

UniProtKB/TrEMBL

A0A8I5ZVC2

Conserved Domains (3) summary

smart00410
Location:33 → 117

IG_like; Immunoglobulin like

pfam13895
Location:317 → 393

Ig_2; Immunoglobulin domain

cl11960
Location:33 → 117

Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

92090263..92152002 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039085781.2 → XP_038941709.1 platelet endothelial cell adhesion molecule isoform X8

UniProtKB/TrEMBL

A0A8I5ZVC2

Conserved Domains (4) summary

pfam13895
Location:316 → 389

Ig_2; Immunoglobulin domain

pfam17736
Location:412 → 469

Ig_C17orf99; C17orf99 Ig domain

cd00096
Location:36 → 38

Ig; Ig strand A' [structural motif]

cl11960
Location:33 → 117

Ig; Immunoglobulin domain
XM_039085779.2 → XP_038941707.1 platelet endothelial cell adhesion molecule isoform X6

UniProtKB/TrEMBL

A0A8I5ZVC2

Conserved Domains (4) summary

pfam13895
Location:316 → 389

Ig_2; Immunoglobulin domain

pfam17736
Location:412 → 469

Ig_C17orf99; C17orf99 Ig domain

cd00096
Location:36 → 38

Ig; Ig strand A' [structural motif]

cl11960
Location:33 → 117

Ig; Immunoglobulin domain
XM_039085776.2 → XP_038941704.1 platelet endothelial cell adhesion molecule isoform X3

UniProtKB/TrEMBL

A0A8I5ZVC2, A0A8I6ADR9

Related

ENSRNOP00000091045.1, ENSRNOT00000106375.2

Conserved Domains (4) summary

pfam13895
Location:316 → 389

Ig_2; Immunoglobulin domain

pfam17736
Location:412 → 469

Ig_C17orf99; C17orf99 Ig domain

cd00096
Location:36 → 38

Ig; Ig strand A' [structural motif]

cl11960
Location:33 → 117

Ig; Immunoglobulin domain
XM_039085780.2 → XP_038941708.1 platelet endothelial cell adhesion molecule isoform X7

UniProtKB/TrEMBL

A0A8I5ZVC2, A0A8I6A674

Related

ENSRNOP00000088286.1, ENSRNOT00000110646.2

Conserved Domains (4) summary

pfam13895
Location:316 → 389

Ig_2; Immunoglobulin domain

pfam17736
Location:412 → 469

Ig_C17orf99; C17orf99 Ig domain

cd00096
Location:36 → 38

Ig; Ig strand A' [structural motif]

cl11960
Location:33 → 117

Ig; Immunoglobulin domain
XM_039085777.2 → XP_038941705.1 platelet endothelial cell adhesion molecule isoform X4

UniProtKB/TrEMBL

A0A8I5ZVC2, A0A8I6A5G8

Related

ENSRNOP00000086124.1, ENSRNOT00000105483.2

Conserved Domains (4) summary

pfam13895
Location:316 → 389

Ig_2; Immunoglobulin domain

pfam17736
Location:412 → 469

Ig_C17orf99; C17orf99 Ig domain

cd00096
Location:36 → 38

Ig; Ig strand A' [structural motif]

cl11960
Location:33 → 117

Ig; Immunoglobulin domain
XM_039085775.2 → XP_038941703.1 platelet endothelial cell adhesion molecule isoform X2

UniProtKB/TrEMBL

A0A8I5ZVC2, A0A8I6AKA0

Related

ENSRNOP00000093793.1, ENSRNOT00000110556.2

Conserved Domains (4) summary

pfam13895
Location:316 → 389

Ig_2; Immunoglobulin domain

pfam17736
Location:412 → 469

Ig_C17orf99; C17orf99 Ig domain

cd00096
Location:36 → 38

Ig; Ig strand A' [structural motif]

cl11960
Location:33 → 117

Ig; Immunoglobulin domain
XM_039085774.2 → XP_038941702.1 platelet endothelial cell adhesion molecule isoform X1

UniProtKB/TrEMBL

A0A8I5ZXI3, A0A8I6GHL3

Related

ENSRNOP00000088919.1, ENSRNOT00000117538.2

Conserved Domains (4) summary

pfam13895
Location:316 → 389

Ig_2; Immunoglobulin domain

pfam17736
Location:412 → 469

Ig_C17orf99; C17orf99 Ig domain

cd00096
Location:36 → 38

Ig; Ig strand A' [structural motif]

cl11960
Location:33 → 117

Ig; Immunoglobulin domain
XM_039085778.2 → XP_038941706.1 platelet endothelial cell adhesion molecule isoform X5

UniProtKB/TrEMBL

A0A8I5ZVC2

Conserved Domains (4) summary

pfam13895
Location:288 → 361

Ig_2; Immunoglobulin domain

pfam17736
Location:384 → 441

Ig_C17orf99; C17orf99 Ig domain

cd00096
Location:8 → 10

Ig; Ig strand A' [structural motif]

cl11960
Location:5 → 89

Ig; Immunoglobulin domain