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    Zyx zyxin [ Rattus norvegicus (Norway rat) ]

    Gene ID: 114636, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Zyxprovided by RGD
    Official Full Name
    zyxinprovided by RGD
    Primary source
    RGD:620698
    See related
    EnsemblRapid:ENSRNOG00000017354 AllianceGenome:RGD:620698
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable metal ion binding activity. Predicted to be involved in cell surface receptor signaling pathway; cell-matrix adhesion; and stress fiber assembly. Predicted to act upstream of or within cellular response to type II interferon. Predicted to be located in several cellular components, including actin cytoskeleton; adherens junction; and phagocytic vesicle. Predicted to be active in cytoplasm; focal adhesion; and stress fiber. Orthologous to human ZYX (zyxin). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 240.8), Spleen (RPKM 168.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Zyx in Genome Data Viewer
    Location:
    4q24
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (72203991..72213181)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (71236767..71246553)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (71740188..71749386)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene chloride voltage-gated channel 1 Neighboring gene family with sequence similarity 131, member B Neighboring gene uncharacterized LOC120102260 Neighboring gene Eph receptor A1 Neighboring gene uncharacterized LOC120102261 Neighboring gene taste receptor, type 2, member 143

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Expression of VASP and zyxin in cochlear pillar cells: indication for actin-based dynamics? Schick B, et al. Cell Tissue Res, 2003 Mar. PMID 12658439
    2. Focal adhesion protein zyxin is a mechanosensitive modulator of gene expression in vascular smooth muscle cells. Cattaruzza M, et al. Hypertension, 2004 Apr. PMID 14967842
    3. Molecular characterization of human zyxin. Macalma T, et al. J Biol Chem, 1996 Dec 6. PMID 8940160
    4. The LIM-domain protein Zyxin binds the homeodomain factor Xanf1/Hesx1 and modulates its activity in the anterior neural plate of Xenopus laevis embryo. Martynova NY, et al. Dev Dyn, 2008 Mar. PMID 18297730
    5. Cytokine-induced down-regulation of zfm1/splicing factor-1 promotes smooth muscle cell proliferation. Cattaruzza M, et al. J Biol Chem, 2002 Feb 22. PMID 11748220

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell-matrix adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cellular response to type II interferon ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in integrin-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in integrin-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in stress fiber assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in transforming growth factor beta receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transforming growth factor beta receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in adherens junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in focal adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in focal adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in phagocytic vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in stress fiber IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in stress fiber ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    zyxin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001398717.2 → NP_001385646.1  zyxin isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      A0A8I6GKY5, A6IF73
      Conserved Domains (5) summary
      cd09353
      Location:436 → 495
      LIM2_Zyxin; The second LIM domain of Zyxin
      cd09435
      Location:496 → 562
      LIM3_Zyxin; The third LIM domain of Zyxin
      PHA03247
      Location:3 → 295
      PHA03247; large tegument protein UL36; Provisional
      PRK10263
      Location:177 → 396
      PRK10263; DNA translocase FtsK; Provisional
      cl02475
      Location:343 → 429
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    2. NM_001398718.2 → NP_001385647.1  zyxin isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      A0A8I6AV84, A0A8I6GKY5, A6IF73
      Related
      ENSRNOP00000097981.1, ENSRNOT00000104565.2

    3. NM_001415801.1 → NP_001402730.1  zyxin isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      A0A8I6GKY5, A6IF73

    4. NM_053761.3 → NP_446213.1  zyxin isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      A0A8I6GKY5, A6IF73
      Related
      ENSRNOP00000023537.6, ENSRNOT00000023537.7
      Conserved Domains (5) summary
      cd09353
      Location:436 → 495
      LIM2_Zyxin; The second LIM domain of Zyxin
      cd09435
      Location:496 → 562
      LIM3_Zyxin; The third LIM domain of Zyxin
      PHA03247
      Location:3 → 295
      PHA03247; large tegument protein UL36; Provisional
      PRK10263
      Location:177 → 396
      PRK10263; DNA translocase FtsK; Provisional
      cl02475
      Location:343 → 429
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      72203991..72213181
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017592382.3 → XP_017447871.1  zyxin isoform X2

      UniProtKB/TrEMBL
      A0A8I6GKY5, A6IF73
      Conserved Domains (5) summary
      cd09353
      Location:436 → 495
      LIM2_Zyxin; The second LIM domain of Zyxin
      cd09435
      Location:496 → 562
      LIM3_Zyxin; The third LIM domain of Zyxin
      PHA03247
      Location:3 → 295
      PHA03247; large tegument protein UL36; Provisional
      PRK10263
      Location:177 → 396
      PRK10263; DNA translocase FtsK; Provisional
      cl02475
      Location:343 → 429
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    2. XM_063285399.1 → XP_063141469.1  zyxin isoform X1

      UniProtKB/TrEMBL
      A0A8I6GKY5, A6IF73
      Related
      ENSRNOP00000094013.1, ENSRNOT00000115210.2
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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