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    Ube2a ubiquitin-conjugating enzyme E2A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 298317, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ube2aprovided by RGD
    Official Full Name
    ubiquitin-conjugating enzyme E2Aprovided by RGD
    Primary source
    RGD:1359534
    See related
    EnsemblRapid:ENSRNOG00000039985 AllianceGenome:RGD:1359534
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable ubiquitin conjugating enzyme activity and ubiquitin protein ligase binding activity. Predicted to be involved in several processes, including G2/M transition of mitotic cell cycle; positive regulation of mitophagy; and protein polyubiquitination. Predicted to act upstream of or within blastocyst hatching; maternal process involved in female pregnancy; and protein ubiquitination. Predicted to be located in XY body and chromatin. Predicted to be part of HULC complex. Human ortholog(s) of this gene implicated in syndromic X-linked intellectual disability Nascimento type. Orthologous to human UBE2A (ubiquitin conjugating enzyme E2 A). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 67.3), Muscle (RPKM 65.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ube2a in Genome Data Viewer
    Location:
    Xq34
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (120979993..120990773)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (116114339..116125076)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (123486988..123497726)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134484096 Neighboring gene solute carrier family 25 member 5 Neighboring gene STING1 ER exit protein 1 Neighboring gene NFKB repressing factor Neighboring gene septin 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The ubiquitin-conjugating DNA repair enzyme HR6A is a maternal factor essential for early embryonic development in mice. Roest HP, et al. Mol Cell Biol, 2004 Jun. PMID 15169909, Free PMC Article
    2. Regulation of the ubiquitin-conjugating enzyme hHR6A by CDK-mediated phosphorylation. Sarcevic B, et al. EMBO J, 2002 Apr 15. PMID 11953320, Free PMC Article
    3. Structural and functional conservation of two human homologs of the yeast DNA repair gene RAD6. Koken MH, et al. Proc Natl Acad Sci U S A, 1991 Oct 15. PMID 1717990, Free PMC Article
    4. Localization of two human homologs, HHR6A and HHR6B, of the yeast DNA repair gene RAD6 to chromosomes Xq24-q25 and 5q23-q31. Koken MH, et al. Genomics, 1992 Mar. PMID 1559696
    5. The human RAD18 gene product interacts with HHR6A and HHR6B. Xin H, et al. Nucleic Acids Res, 2000 Jul 15. PMID 10908344, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin conjugating enzyme activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin conjugating enzyme activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA repair ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in G2/M transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    acts_upstream_of_or_within blastocyst hatching ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in chromatin remodeling ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT acts_upstream_of_or_within in utero embryonic development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within in utero embryonic development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within maternal process involved in female pregnancy ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of mitophagy ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein K11-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein K48-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein polyubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to UV ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of HULC complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of HULC complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in XY body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in chromatin ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ubiquitin-conjugating enzyme E2 A
    Names
    ubiquitin-conjugating enzyme E2A (RAD6 homolog)
    NP_001013955.1
    XP_006257508.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013933.2 → NP_001013955.1  ubiquitin-conjugating enzyme E2 A isoform 2

      See identical proteins and their annotated locations for NP_001013955.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/TrEMBL
      A0A8I6A8J6, Q6AXR9
      Conserved Domains (1) summary
      pfam00179
      Location:8 → 155
      UQ_con; Ubiquitin-conjugating enzyme

    2. NM_001433955.1 → NP_001420884.1  ubiquitin-conjugating enzyme E2 A isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/TrEMBL
      A0A0G2K8F7, A6JMG4

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      120979993..120990773
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006257446.5 → XP_006257508.1  ubiquitin-conjugating enzyme E2 A isoform X1

      Related
      ENSRNOP00000088675.1, ENSRNOT00000111044.2
      Conserved Domains (1) summary
      pfam00179
      Location:8 → 145
      UQ_con; Ubiquitin-conjugating enzyme
    Nucleotide Protein Strain
    Heading Accession and Version

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