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    TRIM5 tripartite motif containing 5 [ Homo sapiens (human) ]

    Gene ID: 85363, updated on 3-Dec-2024

    Summary

    Official Symbol
    TRIM5provided by HGNC
    Official Full Name
    tripartite motif containing 5provided by HGNC
    Primary source
    HGNC:HGNC:16276
    See related
    Ensembl:ENSG00000132256 MIM:608487; AllianceGenome:HGNC:16276
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RNF88; TRIM5alpha
    Summary
    The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein forms homo-oligomers via the coilel-coil region and localizes to cytoplasmic bodies. It appears to function as a E3 ubiquitin-ligase and ubiqutinates itself to regulate its subcellular localization. It may play a role in retroviral restriction. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Dec 2009]
    Expression
    Ubiquitous expression in urinary bladder (RPKM 5.4), endometrium (RPKM 5.4) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See TRIM5 in Genome Data Viewer
    Location:
    11p15.4
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (5588635..5685074, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (5647845..5742931, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (5684425..5706304, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene heterogeneous nuclear ribonucleoprotein A1 pseudogene 53 Neighboring gene Sharpr-MPRA regulatory region 4920 Neighboring gene olfactory receptor family 52 subfamily B member 6 Neighboring gene Sharpr-MPRA regulatory region 11830 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:5617638-5618555 Neighboring gene TRIM6-TRIM34 readthrough Neighboring gene Sharpr-MPRA regulatory region 4679 Neighboring gene tripartite motif containing 6 Neighboring gene NANOG hESC enhancer GRCh37_chr11:5642663-5643271 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4327 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4328 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4329 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4330 Neighboring gene tripartite motif containing 34 Neighboring gene uncharacterized LOC107984302 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr11:5700031-5701230 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4331 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr11:5711125-5712324 Neighboring gene uncharacterized LOC124902620 Neighboring gene tripartite motif containing 22 Neighboring gene olfactory receptor family 52 subfamily U member 1 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    GWAS of DNA methylation variation within imprinting control regions suggests parent-of-origin association.
    EBI GWAS Catalog
    Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
    EBI GWAS Catalog

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    HIV-1 replication is inhibited by TRIM5 expression in Jurkat T cells PubMed
    TRIM5 (TRIM5alpha) R332G-R335G mutant protein efficiently restricts HIV-1 IIIB infection spreading/replicaton in CEM.NKR-CCR5 cells PubMed
    Female Pumwani sex workers with the TRIM5 R136Q polymorphism (rs10838525) were less likely to seroconvert despite repeated heavy exposure to HIV-1. PubMed
    Higher TRIM5 (TRIM5alpha) H43Y homozygotes reported in sero-negative Chinese intravenous drug users than in HIV-infected drug users; HIV-1 infection/transmission is restricted by TRIM5 43Y variant [in a Chinese intravenous drug user cohort] PubMed
    TRIM5 (TRIM5alpha) 43Y allele was found less frequently in Japanese and Indian HIV-1-infected individuals relative to ethnicity-matched controls PubMed
    TRIM5 (TRIM5alpha) 43Y vairant protects against HIV-1 transmisssion in African-Americans; HIV-1 is restricted by TRIM5 43Y variant PubMed
    HIV/tuberculosis coinfection upregulates TRIM5 expression in pleural fluid mononuclear cells (PFMC) isolated from antiretroviral-naive coinfected patients (relative to patients infected with tuberculosis only) PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Pr55(Gag) gag The viruses expressing Gag proteins from clinical isolates show differences in their sensitivity to TRIM5alpha, which is dependent on the TRIM5alpha alleles that the virus encounters PubMed
    Tat tat Overexpression of HIV-1 Tat results in a nonspecific activation of the expression of TRIM5alpha PubMed
    Vpu vpu The expression of TRIM5 is enhanced in Vpu-deficient HIV-1-infected cells as compared to that in wild-type-infected cells PubMed
    capsid gag HIV-1 infection is modestly restricted by human TRIM5alpha, which acts on the incoming HIV-1 capsid PubMed
    gag Removal of a positively charged residue at position 332 of human TRIM5alpha increases its restricting activity by increasing the ability of TRIM5alpha to bind HIV-1 capsid complexes PubMed
    gag Intra- and inter-hexamer crosslinking demonstrate the interaction between HIV-1 CA and human TRIM5alpha CC-SPRY domains (residues 132-493) PubMed
    gag HIV-1 CA residues 83, 89, 120, 122 and the aromatic residues 117, 130, and 133 modulate its sensitivity to TRIM5alpha PubMed
    gag TRIM5alpha disrupts the regular cylindrical hexameric lattice structure of HIV-1 CA-NC complex PubMed
    gag HIV-1 capsid is more rapidly degraded in cells expressing monkey TRIM5alpha than in cells expressing human TRIM5alpha PubMed
    gag R332G/R335G and R330E/R332G/R335G mutants of TRIM5alpha binds the in vitro-assembled CA-NC complexes and the strength of the interaction correlates with the magnitude of restriction PubMed
    gag Mutation G330E in the v1 TRIM5alpha region exhibits a strong level of HIV-1 resistance, while mutations G330A or G330S have little or no effect PubMed
    gag The level of susceptibility hTRIM5alpha expressed by viruses carrying HIV-2 CA sequences in the context of HIV-1 NL4-3 is higher than that of HIV-1 NL4-3 and markedly higher than a panel of primary HIV-1 CA sequences PubMed
    gag HIV-1 CA-V86M mutant is partially resistant to restriction by hTRIM5alpha mutant R322G/R335G. The restriction of CA-V86M by hTRIM5alpha R322G/R335G is independent of cyclophilin A, but correlates with its sensitivity to cyclosporine A treatment PubMed
    gag TRIM5alpha allelic variants R136Q/H419Y and H43Y/G249D are generally inactive for HIV-1 CA inhibition PubMed
    gag The T216I mutation in HIV-1 CA restores the ability of P38A CA mutant particles to saturate TRIM5alpha host restrictions in monkey cells PubMed
    gag The TAK1 kinase complex (TAK1/TAB2/TAB3) contributes to capsid-specific restriction mediated by TRIM5alpha. TRIM5alpha activates TAK1 autophosphorylation PubMed
    gag Human TRIM5-alpha and TRIM5-delta proteins are dominant negative to HIV-1 restriction in rabbit cells PubMed
    gag TRIM5alpha associates with HIV-1 capsid-nucleocapsid complexes assembled in vitro, and the TRIM5alpha interaction with these complexes is dependent on its B30.2(SPRY) domains PubMed
    gag Cluster I-A and Cluster II-A changes in the B-box 2 domain of TRIM5alpha decrease its binding to HIV-1 Capsid PubMed
    gag Two B-box TRIM5alpha mutants (Cluster I-A:Q109E, E110K, V114A, I115L, and L118V; Cluster II-A:E120A, R121Q, Q123R, and E124K) abolish the weak restricting activity against HIV-1 associated with wild-type TRIM5alpha PubMed
    gag Human TRIM5alpha modestly, but specifically, inhibits an HIV-1 strain carrying a mutation (G89V) in the cyclophilin binding loop in capsid PubMed
    gag The effect of inhibition of CA-CypA interaction by TRIM5alpha is virus isolates-dependent, which can result in inhibition, no change, or an increase in viral infectivity PubMed
    gag TRIM5alpha binds to HIV-1 CA tubular assemblies in a dose-dependent manner, especially at P207/T216 inter-hexamer interfaces PubMed
    nucleocapsid gag R332G/R335G and R330E/R332G/R335G mutants of TRIM5alpha binds the in vitro-assembled CA-NC complexes and the strength of the interaction correlates with the magnitude of restriction PubMed
    gag TRIM5alpha disrupts the regular cylindrical hexameric lattice structure of HIV-1 CA-NC complex PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • AC015691.13

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables pattern recognition receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein homodimerization activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein homodimerization activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-macromolecule adaptor activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transcription coactivator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ubiquitin-protein transferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in activation of innate immune response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in autophagy IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in defense response to virus TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in innate immune response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of viral entry into host cell IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of DNA-binding transcription factor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of MAPK cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of NF-kappaB transcription factor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of canonical NF-kappaB signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of canonical NF-kappaB signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of canonical NF-kappaB signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein K63-linked ubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of gene expression IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of lipopolysaccharide-mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of protein localization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of protein localization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of viral entry into host cell IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in suppression of viral release by host IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in P-body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    colocalizes_with omegasome IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    tripartite motif-containing protein 5
    Names
    RING-type E3 ubiquitin transferase TRIM5
    ring finger protein 88
    tripartite motif protein TRIM5
    tripartite motif-containing protein 5 alpha
    NP_001397887.1
    NP_149023.2
    NP_149083.2
    NP_149084.2
    XP_005253240.1
    XP_005253241.1
    XP_006718421.1
    XP_011518728.1
    XP_016873949.1
    XP_016873950.1
    XP_047283739.1
    XP_047283740.1
    XP_054226288.1
    XP_054226289.1
    XP_054226290.1
    XP_054226291.1
    XP_054226292.1
    XP_054226293.1
    XP_054226294.1
    XP_054226295.1
    XP_054226296.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029122.2 RefSeqGene

      Range
      5000..26879
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001410958.1NP_001397887.1  tripartite motif-containing protein 5 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC015691, AC109341
      Consensus CDS
      CCDS91425.1
      UniProtKB/TrEMBL
      A0A804HHS7
      Related
      ENSP00000506742.1, ENST00000682968.1
    2. NM_033034.3NP_149023.2  tripartite motif-containing protein 5 isoform alpha

      See identical proteins and their annotated locations for NP_149023.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (alpha) encodes the longest isoform (alpha).
      Source sequence(s)
      AC015691, AK027593, CN334837, DA475412
      Consensus CDS
      CCDS31393.1
      UniProtKB/Swiss-Prot
      A6NGQ1, A8WFA8, D3DQS8, D3DQS9, G3GJY1, Q2MLV4, Q2MLV8, Q2MLV9, Q2MLW1, Q2MLW3, Q2MLW4, Q2MLW6, Q2MLW7, Q2MLX1, Q2MLX2, Q2MLX3, Q2MLX5, Q2MLY3, Q2MLY4, Q2V6Q6, Q6GX26, Q8WU46, Q96SR5, Q9C031, Q9C032, Q9C033, Q9C034, Q9C035
      UniProtKB/TrEMBL
      B1Q3L0
      Related
      ENSP00000369373.3, ENST00000380034.8
      Conserved Domains (3) summary
      smart00336
      Location:90130
      BBOX; B-Box-type zinc finger
      cd00162
      Location:1459
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      cd15822
      Location:288489
      SPRY_PRY_TRIM5; PRY/SPRY domain in tripartite motif-binding protein 5 (TRIM5), also known as RING finger protein 88 (RNF88)
    3. NM_033092.4NP_149083.2  tripartite motif-containing protein 5 isoform gamma

      See identical proteins and their annotated locations for NP_149083.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (gamma) includes an alternate segment in the 3' coding region, compared to variant alpha, which results in a frameshift. The resulting protein (isoform gamma) has a shorter and distinct C-terminus, compared to isoform alpha.
      Source sequence(s)
      AC015691, AF220027, AK074363, BC021258, CN334837, DA475412
      Consensus CDS
      CCDS31394.1
      UniProtKB/Swiss-Prot
      Q9C035
      Related
      ENSP00000380058.3, ENST00000396847.7
      Conserved Domains (4) summary
      smart00336
      Location:90130
      BBOX; B-Box-type zinc finger
      pfam12325
      Location:130175
      TMF_TATA_bd; TATA element modulatory factor 1 TATA binding
      cd16591
      Location:1260
      RING-HC_TRIM5_like-C-IV; RING finger, HC subclass, found in tripartite motif-containing proteins TRIM5, TRIM6, TRIM22, TRIM34 and similar proteins
      cl25732
      Location:116240
      SMC_N; RecF/RecN/SMC N terminal domain
    4. NM_033093.4NP_149084.2  tripartite motif-containing protein 5 isoform delta

      See identical proteins and their annotated locations for NP_149084.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (delta) differs in the 5' UTR and uses an alternate splice site in the 3' terminal exon, which results in a frameshift, compared to variant alpha. The encoded isoform (delta) has a shorter and distinct C-terminus, compared to isoform alpha.
      Source sequence(s)
      AC015691, AC109341, DA475412
      Consensus CDS
      CCDS31392.1
      UniProtKB/Swiss-Prot
      Q9C035
      Related
      ENSP00000369366.1, ENST00000380027.5
      Conserved Domains (2) summary
      smart00336
      Location:90130
      BBOX; B-Box-type zinc finger
      cd00162
      Location:1459
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      5588635..5685074 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047427783.1XP_047283739.1  tripartite motif-containing protein 5 isoform X5

    2. XM_047427784.1XP_047283740.1  tripartite motif-containing protein 5 isoform X7

      UniProtKB/TrEMBL
      E7EQQ5
      Related
      ENSP00000388031.1, ENST00000412903.1
    3. XM_005253183.4XP_005253240.1  tripartite motif-containing protein 5 isoform X1

      See identical proteins and their annotated locations for XP_005253240.1

      UniProtKB/Swiss-Prot
      A6NGQ1, A8WFA8, D3DQS8, D3DQS9, G3GJY1, Q2MLV4, Q2MLV8, Q2MLV9, Q2MLW1, Q2MLW3, Q2MLW4, Q2MLW6, Q2MLW7, Q2MLX1, Q2MLX2, Q2MLX3, Q2MLX5, Q2MLY3, Q2MLY4, Q2V6Q6, Q6GX26, Q8WU46, Q96SR5, Q9C031, Q9C032, Q9C033, Q9C034, Q9C035
      UniProtKB/TrEMBL
      B1Q3L0
      Related
      ENSP00000507420.1, ENST00000684655.1
      Conserved Domains (3) summary
      smart00336
      Location:90130
      BBOX; B-Box-type zinc finger
      cd00162
      Location:1459
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      cd15822
      Location:288489
      SPRY_PRY_TRIM5; PRY/SPRY domain in tripartite motif-binding protein 5 (TRIM5), also known as RING finger protein 88 (RNF88)
    4. XM_006718358.4XP_006718421.1  tripartite motif-containing protein 5 isoform X6

      UniProtKB/TrEMBL
      A0A804HHS7
      Conserved Domains (2) summary
      smart00336
      Location:90130
      BBOX; B-Box-type zinc finger
      cd00162
      Location:1459
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    5. XM_017018461.3XP_016873950.1  tripartite motif-containing protein 5 isoform X4

      Conserved Domains (2) summary
      smart00336
      Location:90130
      BBOX; B-Box-type zinc finger
      cd00162
      Location:1459
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    6. XM_011520426.4XP_011518728.1  tripartite motif-containing protein 5 isoform X4

      Conserved Domains (2) summary
      smart00336
      Location:90130
      BBOX; B-Box-type zinc finger
      cd00162
      Location:1459
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    7. XM_005253184.4XP_005253241.1  tripartite motif-containing protein 5 isoform X2

      See identical proteins and their annotated locations for XP_005253241.1

      UniProtKB/Swiss-Prot
      Q9C035
      Conserved Domains (2) summary
      smart00336
      Location:90130
      BBOX; B-Box-type zinc finger
      cd00162
      Location:1459
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    8. XM_017018460.3XP_016873949.1  tripartite motif-containing protein 5 isoform X3

    RNA

    1. XR_007062522.1 RNA Sequence

    2. XR_007062518.1 RNA Sequence

    3. XR_007062519.1 RNA Sequence

    4. XR_001748014.3 RNA Sequence

    5. XR_007062521.1 RNA Sequence

    6. XR_007062520.1 RNA Sequence

    7. XR_007062517.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      5647845..5742931 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054370319.1XP_054226294.1  tripartite motif-containing protein 5 isoform X5

    2. XM_054370318.1XP_054226293.1  tripartite motif-containing protein 5 isoform X8

    3. XM_054370313.1XP_054226288.1  tripartite motif-containing protein 5 isoform X1

      UniProtKB/TrEMBL
      B1Q3L0
    4. XM_054370321.1XP_054226296.1  tripartite motif-containing protein 5 isoform X6

    5. XM_054370317.1XP_054226292.1  tripartite motif-containing protein 5 isoform X4

    6. XM_054370316.1XP_054226291.1  tripartite motif-containing protein 5 isoform X4

    7. XM_054370314.1XP_054226289.1  tripartite motif-containing protein 5 isoform X2

    8. XM_054370320.1XP_054226295.1  tripartite motif-containing protein 5 isoform X9

    9. XM_054370315.1XP_054226290.1  tripartite motif-containing protein 5 isoform X3

    RNA

    1. XR_008488481.1 RNA Sequence

    2. XR_008488483.1 RNA Sequence

    3. XR_008488478.1 RNA Sequence

    4. XR_008488480.1 RNA Sequence

    5. XR_008488479.1 RNA Sequence

    6. XR_008488482.1 RNA Sequence