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    Pard3b par-3 family cell polarity regulator beta [ Rattus norvegicus (Norway rat) ]

    Gene ID: 301455, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pard3bprovided by RGD
    Official Full Name
    par-3 family cell polarity regulator betaprovided by RGD
    Primary source
    RGD:1584992
    See related
    EnsemblRapid:ENSRNOG00000024345 AllianceGenome:RGD:1584992
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable phosphatidylinositol binding activity. Predicted to be involved in several processes, including establishment of cell polarity; establishment of centrosome localization; and establishment or maintenance of epithelial cell apical/basal polarity. Predicted to be located in cell junction. Predicted to be part of protein-containing complex. Predicted to be active in several cellular components, including adherens junction; apical junction complex; and apical plasma membrane. Orthologous to human PARD3B (par-3 family cell polarity regulator beta). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 119.1), Heart (RPKM 117.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Pard3b in Genome Data Viewer
    Location:
    9q32
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (70532358..71561044)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (63038435..64067178)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (68414339..69426226)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102548093 Neighboring gene phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase, pseudogene 7 Neighboring gene uncharacterized LOC134480584 Neighboring gene uncharacterized LOC134480583 Neighboring gene uncharacterized LOC134480585 Neighboring gene neuropilin 2 Neighboring gene uncharacterized LOC102548410

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Two forms of human Inscuteable-related protein that links Par3 to the Pins homologues LGN and AGS3. Izaki T, et al. Biochem Biophys Res Commun, 2006 Mar 24. PMID 16458856
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables phosphatidylinositol binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in establishment of cell polarity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in establishment of centrosome localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in establishment or maintenance of epithelial cell apical/basal polarity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in microtubule cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in adherens junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in apical junction complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in apical plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in bicellular tight junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cell cortex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cell junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    partitioning defective 3 homolog B
    Names
    par-3 partitioning defective 3 homolog B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191808.3 → NP_001178737.1  partitioning defective 3 homolog B

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A0A8I5ZQH3, A0A8I6A8L0
      Related
      ENSRNOP00000109415.1, ENSRNOT00000138401.1
      Conserved Domains (3) summary
      smart00228
      Location:380 → 469
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:501 → 589
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam12053
      Location:1 → 143
      DUF3534; Domain of unknown function (DUF3534)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      70532358..71561044
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039083322.2 → XP_038939250.1  partitioning defective 3 homolog B isoform X1

      UniProtKB/TrEMBL
      F1LW22
      Related
      ENSRNOP00000039831.6, ENSRNOT00000040778.6
      Conserved Domains (3) summary
      smart00228
      Location:380 → 469
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:501 → 589
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam12053
      Location:2 → 83
      DUF3534; N-terminal of Par3 and HAL proteins

    2. XM_063266952.1 → XP_063123022.1  partitioning defective 3 homolog B isoform X2

      UniProtKB/TrEMBL
      A0A8I6GJB2
    Nucleotide Protein Strain
    Heading Accession and Version

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