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    Nomo1 Nodal modulator 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361578, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Nomo1provided by RGD
    Official Full Name
    Nodal modulator 1provided by RGD
    Primary source
    RGD:1305240
    See related
    EnsemblRapid:ENSRNOG00000021118 AllianceGenome:RGD:1305240
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1305240
    Summary
    Predicted to enable ribosome binding activity. Predicted to be involved in multi-pass transmembrane protein insertion into ER membrane. Predicted to be part of multi-pass translocon complex. Predicted to be active in endoplasmic reticulum membrane. Orthologous to several human genes including NOMO2 (NODAL modulator 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 374.4), Kidney (RPKM 201.2) and 9 other tissues See more
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    Genomic context

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    See Nomo1 in Genome Data Viewer
    Location:
    1q22
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (105641867..105692708)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (96505460..96556280)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (102017247..102068871)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene outer dynein arm docking complex subunit 1 Neighboring gene ATP binding cassette subfamily C member 6 Neighboring gene natural killer cell cytotoxicity receptor 3 ligand 1 Neighboring gene erythrocyte membrane protein band 4.1 like 5, pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The Nicastrin-like protein Nicalin regulates assembly and stability of the Nicalin-nodal modulator (NOMO) membrane protein complex. Haffner C, et al. J Biol Chem, 2007 Apr 6. PMID 17261586
    2. Transmembrane protein 147 (TMEM147) is a novel component of the Nicalin-NOMO protein complex. Dettmer U, et al. J Biol Chem, 2010 Aug 20. PMID 20538592, Free PMC Article
    3. Phosphorylation and degradation of tomosyn-2 de-represses insulin secretion. Bhatnagar S, et al. J Biol Chem, 2014 Sep 5. PMID 25002582, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ribosome binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in multi-pass transmembrane protein insertion into ER membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of multi-pass translocon complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    Nodal modulator 1; nodal modulator 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108484.1 → NP_001101954.1  Nodal modulator 1 precursor

      See identical proteins and their annotated locations for NP_001101954.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473979
      UniProtKB/TrEMBL
      A0A8I5ZY21, A6JBA9
      Related
      ENSRNOP00000084848.2, ENSRNOT00000108370.2
      Conserved Domains (2) summary
      pfam05738
      Location:867 → 919
      Cna_B; Cna protein B-type domain
      pfam13620
      Location:322 → 374
      CarboxypepD_reg; Carboxypeptidase regulatory-like domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      105641867..105692708
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006229108.5 → XP_006229170.1  nodal modulator 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZY21, D3ZSA9
      Related
      ENSRNOP00000028680.6, ENSRNOT00000028680.7
      Conserved Domains (2) summary
      pfam05738
      Location:867 → 919
      Cna_B; Cna protein B-type domain
      pfam13620
      Location:322 → 374
      CarboxypepD_reg; Carboxypeptidase regulatory-like domain
    Nucleotide Protein Strain
    Heading Accession and Version

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