Tnfrsf11a TNF receptor superfamily member 11A [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tnfrsf11aprovided by RGD
Official Full Name: TNF receptor superfamily member 11Aprovided by RGD
Primary source: RGD:1563614
See related: EnsemblRapid:ENSRNOG00000015615 AllianceGenome:RGD:1563614
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RANK; RGD1563614
Summary: Predicted to enable cytokine binding activity and tumor necrosis factor receptor activity. Involved in several processes, including cellular response to zinc ion starvation; osteoclast differentiation; and response to insulin. Predicted to be located in several cellular components, including cell surface; cytosol; and membrane raft. Predicted to be active in external side of plasma membrane. Biomarker of myocarditis. Human ortholog(s) of this gene implicated in bone development disease and bone remodeling disease (multiple). Orthologous to human TNFRSF11A (TNF receptor superfamily member 11a). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Lung (RPKM 26.6), Brain (RPKM 24.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 13p11

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	13	NC_086031.1 (22442930..22501257)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	13	NC_051348.1 (21928370..21986719)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	13	NC_005112.4 (25778306..25835802)

Chromosome 13 - NC_086031.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Autophagy regulates bone loss via the RANKL/RANK/OPG axis in an experimental rat apical periodontitis model.
Title: Autophagy regulates bone loss via the RANKL/RANK/OPG axis in an experimental rat apical periodontitis model.
A decrease in the RANKL/OPG ratio, associated with PTH-dependent activation of the anabolic PTH1R/ATF4 pathway, seems to be responsible for the unexpected, beneficial effect of PTH on cortical bone accrual and strength.
Title: RANKL/OPG system regulation by endogenous PTH and PTH1R/ATF4 axis in bone: Implications for bone accrual and strength in growing rats with mild uremia.
results of this study concluded that the RANK, RANK-L and OPG system participates in bone remodeling after rapid maxillary expansion
Title: RANK/RANKL/OPG Expression in Rapid Maxillary Expansion.
in this animal model the increase of RANK/RANKL and HGF markers is related to a specific immune response, and probably contributed to the evolution of periodontal disease
Title: Evolution of Periodontal Disease: Immune Response and RANK/RANKL/OPG System.
study identified a number of differentially expressed bone-related mRNAs of potential significance and confirmed the osteoprotegerin/receptor activator of nuclear factor kappa-B (RANK)/RANK ligand (RANKL) pathway
Title: Differential gene expression in the otic capsule and the middle ear--an annotation of bone-related signaling genes.
A deficiency of Zn decreased osteoclastogenesis associated with the reduced expression of RANK through a decrease in MITF protein, and osteoblastogenesis associated with the reduced expression of Runx2.
Title: Zinc deficiency decreases osteoblasts and osteoclasts associated with the reduced expression of Runx2 and RANK.
Studied the molecular basis for M-CSF-induced ROS generation and RANK expression in the early stages of osteoclastic differentiation. Generation of ROS by M-CSF was mediated by Nox2 and was required for the expression of RANK associated with ERK.
Title: A crucial role for reactive oxygen species in macrophage colony-stimulating factor-induced RANK expression in osteoclastic differentiation.
the increase in RANK-RANKL expression is a response to podocyte injury, and RANK-RANKL may be a novel receptor-ligand complex for the survival response during podocyte injury.
Title: Receptor activator of NF-kappaB and podocytes: towards a function of a novel receptor-ligand pair in the survival response of podocyte injury.
Pulsed electromagnetic fields did not significantly affect RANK expression in ovarectomized rats.
Title: Effects of pulsed electromagnetic fields on the mRNA expression of CAII and RANK in ovariectomized rats.
The level of RANK protein increased and Runx2 protein decreased in diabetic rats.
Title: Increased expression of the receptor for activation of NF-kappaB and decreased runt-related transcription factor 2 expression in bone of rats with streptozotocin-induced diabetes.

Submit: New GeneRIF Correction See all GeneRIFs (14)

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables cytokine binding	IBA Inferred from Biological aspect of Ancestor more info
enables cytokine binding	ISO Inferred from Sequence Orthology more info
enables transmembrane signaling receptor activity	ISO Inferred from Sequence Orthology more info
enables tumor necrosis factor receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables tumor necrosis factor receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in adaptive immune response	ISO Inferred from Sequence Orthology more info
involved_in cellular response to zinc ion starvation	IEP Inferred from Expression Pattern more info	PubMed
involved_in circadian temperature homeostasis	ISO Inferred from Sequence Orthology more info
involved_in lymph node development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within lymph node development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within mammary gland alveolus development	ISO Inferred from Sequence Orthology more info
involved_in multinuclear osteoclast differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within multinuclear osteoclast differentiation	ISO Inferred from Sequence Orthology more info
involved_in ossification	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within ossification	ISO Inferred from Sequence Orthology more info
involved_in osteoclast differentiation	IEP Inferred from Expression Pattern more info	PubMed
involved_in osteoclast differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of JUN kinase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of NF-kappaB transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of bone resorption	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of bone resorption	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of fever generation by positive regulation of prostaglandin secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of osteoclast differentiation	ISO Inferred from Sequence Orthology more info
involved_in response to ethanol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to insulin	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to interleukin-1	ISO Inferred from Sequence Orthology more info
involved_in response to lipopolysaccharide	ISO Inferred from Sequence Orthology more info
involved_in response to mechanical stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to organic cyclic compound	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to tumor necrosis factor	ISO Inferred from Sequence Orthology more info
involved_in tumor necrosis factor-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in tumor necrosis factor-mediated signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in membrane raft	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: tumor necrosis factor receptor superfamily member 11A

Names: tumor necrosis factor receptor superfamily, member 11a, NFKB activator

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001271235.1 → NP_001258164.1 tumor necrosis factor receptor superfamily member 11A precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000013

UniProtKB/TrEMBL

F1M8Z6

Related

ENSRNOP00000021129.5, ENSRNOT00000021129.6

Conserved Domains (1) summary

cd13411
Location:34 → 196

TNFRSF11A; Tumor necrosis factor receptor superfamily member 11A (TNFRSF11A), also known as receptor activator of nuclear factor-kappaB (RANK)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086031.1 Reference GRCr8

Range

22442930..22501257

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_008769487.4 → XP_008767709.1 tumor necrosis factor receptor superfamily member 11A isoform X1

Conserved Domains (1) summary

cl22855
Location:104 → 154

TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)