Usp18 ubiquitin specific peptidase 18 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Usp18provided by RGD
Full Name: ubiquitin specific peptidase 18provided by RGD
Primary source: RGD:1359153
See related: EnsemblRapid:ENSRNOG00000037198 AllianceGenome:RGD:1359153
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable ISG15-specific peptidase activity; cysteine-type deubiquitinase activity; and molecular adaptor activity. Predicted to be involved in several processes, including antiviral innate immune response; regulation of defense response; and response to stilbenoid. Predicted to act upstream of or within response to bacterium. Predicted to be located in intracellular membrane-bounded organelle. Predicted to be active in cytosol and nucleus. Orthologous to several human genes including USP18 (ubiquitin specific peptidase 18). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 212.3), Spleen (RPKM 126.0) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q42

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (156143770..156171292)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (154471634..154499154)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (153812312..153834374)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MFN2-dependent mitochondrial dysfunction contributes to Relm-beta-induced pulmonary arterial hypertension via USP18/Twist1/miR-214 pathway.
Title: MFN2-dependent mitochondrial dysfunction contributes to Relm-β-induced pulmonary arterial hypertension via USP18/Twist1/miR-214 pathway.
USP18 Stabilized FTO Protein to Activate Mitophagy in Ischemic Stroke Through Repressing m6A Modification of SIRT6.
Title: USP18 Stabilized FTO Protein to Activate Mitophagy in Ischemic Stroke Through Repressing m6A Modification of SIRT6.
USP18 Curbs the Progression of Metabolic Hypertension by Suppressing JAK/STAT Pathway.
Title: USP18 Curbs the Progression of Metabolic Hypertension by Suppressing JAK/STAT Pathway.
USP18 overexpression protects against spinal cord ischemia/reperfusion injury via regulating autophagy.
Title: USP18 overexpression protects against spinal cord ischemia/reperfusion injury via regulating autophagy.

Submit: New GeneRIF Correction

General gene information

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Markers

RH130260 (e-PCR)
- UniSTS:213547

RH144655 (e-PCR)
- UniSTS:233900

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ISG15-specific peptidase activity	ISO Inferred from Sequence Orthology more info
enables cysteine-type deubiquitinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables molecular adaptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in antiviral innate immune response	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of type I interferon-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in protein deubiquitination	IEA Inferred from Electronic Annotation more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
involved_in regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein stability	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within response to bacterium	ISO Inferred from Sequence Orthology more info
involved_in response to stilbenoid	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ubl carboxyl-terminal hydrolase 18

NP_001014080.1

EC 3.1.2.-

XP_038963593.1

EC 3.1.2.-

XP_038963594.1

EC 3.1.2.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001014058.2 → NP_001014080.1 ubl carboxyl-terminal hydrolase 18

See identical proteins and their annotated locations for NP_001014080.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000004

UniProtKB/TrEMBL

F1LNS1, Q6AYC7

Related

ENSRNOP00000053020.3, ENSRNOT00000056174.6

Conserved Domains (2) summary

cd02257
Location:53 → 358

Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...

pfam00443
Location:52 → 357

UCH; Ubiquitin carboxyl-terminal hydrolase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086022.1 Reference GRCr8

Range

156143770..156171292

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039107666.2 → XP_038963594.1 ubl carboxyl-terminal hydrolase 18 isoform X2

UniProtKB/TrEMBL

A6ILC0

Conserved Domains (1) summary

pfam00443
Location:52 → 279

UCH; Ubiquitin carboxyl-terminal hydrolase
XM_039107665.1 → XP_038963593.1 ubl carboxyl-terminal hydrolase 18 isoform X1

UniProtKB/TrEMBL

A6ILC1

Conserved Domains (1) summary

cd02257
Location:50 → 288

Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...