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    Sos2 SOS Ras/Rho guanine nucleotide exchange factor 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 85384, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Sos2provided by RGD
    Official Full Name
    SOS Ras/Rho guanine nucleotide exchange factor 2provided by RGD
    Primary source
    RGD:620435
    See related
    EnsemblRapid:ENSRNOG00000004826 AllianceGenome:RGD:620435
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Sos1
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity. Involved in positive regulation of small GTPase mediated signal transduction. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in Noonan syndrome 9. Orthologous to human SOS2 (SOS Ras/Rho guanine nucleotide exchange factor 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 116.0), Kidney (RPKM 88.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Sos2 in Genome Data Viewer
    Location:
    6q24
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (93778971..93892161, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (88042966..88156140, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (91885292..92008059, complement)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479215 Neighboring gene valosin containing protein lysine methyltransferase Neighboring gene acid phosphatase 1, pseudogene 1 Neighboring gene chloride intracellular channel protein 4 pseudogene Neighboring gene L-2-hydroxyglutarate dehydrogenase Neighboring gene distal membrane arm assembly component 2 like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Antipsychotic drug treatment induces differential gene expression in the rat cortex. Kontkanen O, et al. J Neurochem, 2002 Dec. PMID 12437575
    2. Src-dependent TrkA transactivation is required for pituitary adenylate cyclase-activating polypeptide 38-mediated Rit activation and neuronal differentiation. Shi GX, et al. Mol Biol Cell, 2010 May 1. PMID 20219970, Free PMC Article
    3. Functional redundancy of Sos1 and Sos2 for lymphopoiesis and organismal homeostasis and survival. Baltanás FC, et al. Mol Cell Biol, 2013 Nov. PMID 24043312, Free PMC Article
    4. Effect of long-term exercise on gene expression of insulin signaling pathway intermediates in skeletal muscle. Kim YB, et al. Biochem Biophys Res Commun, 1999 Jan 27. PMID 9920808
    5. Sam68 associates with the SH3 domains of Grb2 recruiting GAP to the Grb2-SOS complex in insulin receptor signaling. Najib S, et al. J Cell Biochem, 2002. PMID 12112020

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Sam68 associates with the SH3 domains of Grb2 recruiting GAP to the Grb2-SOS complex in insulin receptor signaling
      Title: Sam68 associates with the SH3 domains of Grb2 recruiting GAP to the Grb2-SOS complex in insulin receptor signaling.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within B cell homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in Ras protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in insulin receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within lymphocyte homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of small GTPase mediated signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of T cell differentiation in thymus ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of T cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of pro-B cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within small GTPase-mediated signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    son of sevenless homolog 2
    Names
    son of sevenless 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001135561.1 → NP_001129033.1  son of sevenless homolog 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A6HBX0, F1MAI3
      Related
      ENSRNOP00000098665.1, ENSRNOT00000140868.1
      Conserved Domains (7) summary
      smart00147
      Location:775 → 1019
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00229
      Location:596 → 740
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00160
      Location:200 → 387
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01261
      Location:438 → 544
      PH_SOS; Son of Sevenless (SOS) Pleckstrin homology (PH) domain
      pfam00125
      Location:60 → 169
      Histone; Core histone H2A/H2B/H3/H4
      pfam00169
      Location:444 → 545
      PH; PH domain
      cl23907
      Location:97 → 147
      H2A; Histone 2A; H2A is a subunit of the nucleosome. The nucleosome is an octamer containing two H2A, H2B, H3, and H4 subunits. The H2A subunit performs essential roles in maintaining structural integrity of the nucleosome, chromatin condensation, and binding ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      93778971..93892161 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008764721.3 → XP_008762943.1  son of sevenless homolog 2 isoform X3

      UniProtKB/TrEMBL
      A0A0G2JVU2, A6HBX0
      Related
      ENSRNOP00000069620.2, ENSRNOT00000089891.3
      Conserved Domains (7) summary
      smart00147
      Location:742 → 986
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00229
      Location:563 → 707
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      smart00325
      Location:208 → 355
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd01261
      Location:405 → 511
      PH_SOS; Son of Sevenless (SOS) Pleckstrin homology (PH) domain
      pfam00125
      Location:60 → 169
      Histone; Core histone H2A/H2B/H3/H4
      pfam00169
      Location:411 → 512
      PH; PH domain
      cl23907
      Location:97 → 147
      H2A; Histone 2A; H2A is a subunit of the nucleosome. The nucleosome is an octamer containing two H2A, H2B, H3, and H4 subunits. The H2A subunit performs essential roles in maintaining structural integrity of the nucleosome, chromatin condensation, and binding ...

    2. XM_039113012.2 → XP_038968940.1  son of sevenless homolog 2 isoform X1

      UniProtKB/TrEMBL
      A6HBX0
      Conserved Domains (5) summary
      smart00147
      Location:774 → 1018
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00229
      Location:595 → 739
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00160
      Location:200 → 386
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01261
      Location:437 → 543
      PH_SOS; Son of Sevenless (SOS) Pleckstrin homology (PH) domain
      pfam00125
      Location:70 → 169
      Histone; Core histone H2A/H2B/H3/H4

    3. XM_039113013.2 → XP_038968941.1  son of sevenless homolog 2 isoform X2

      UniProtKB/TrEMBL
      A6HBX0
      Related
      ENSRNOP00000101962.1, ENSRNOT00000134978.1
      Conserved Domains (5) summary
      smart00147
      Location:775 → 1019
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00229
      Location:596 → 740
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00160
      Location:200 → 387
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01261
      Location:438 → 544
      PH_SOS; Son of Sevenless (SOS) Pleckstrin homology (PH) domain
      pfam00125
      Location:70 → 169
      Histone; Core histone H2A/H2B/H3/H4

    4. XM_063262560.1 → XP_063118630.1  son of sevenless homolog 2 isoform X4

      UniProtKB/TrEMBL
      A6HBX0

    5. XM_006240184.5 → XP_006240246.1  son of sevenless homolog 2 isoform X5

      UniProtKB/TrEMBL
      A6HBX0
      Conserved Domains (5) summary
      smart00147
      Location:603 → 847
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00229
      Location:424 → 568
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00160
      Location:28 → 215
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01261
      Location:266 → 372
      PH_SOS; Son of Sevenless (SOS) Pleckstrin homology (PH) domain
      pfam00169
      Location:272 → 373
      PH; PH domain
    Nucleotide Protein Strain
    Heading Accession and Version

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