Bco1 beta-carotene oxygenase 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Bco1provided by RGD
Official Full Name: beta-carotene oxygenase 1provided by RGD
Primary source: RGD:70981
See related: EnsemblRapid:ENSRNOG00000012027 AllianceGenome:RGD:70981
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Bcdo; Bcmo1
Summary: Enables beta-carotene 15,15'-dioxygenase activity. Involved in retinoid metabolic process. Predicted to be located in cytosol. Orthologous to human BCO1 (beta-carotene oxygenase 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Liver (RPKM 26.3), Uterus (RPKM 8.2) and 3 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 19q12

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	19	NC_086037.1 (62058061..62094923)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	19	NC_051354.1 (45149250..45186102)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	19	NC_005118.4 (49637059..49673577)

Chromosome 19 - NC_086037.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

cellular localization of beta-carotene 15,15' oxygenase-1 (BCO1) and beta-carotene 9',10' oxygenase-2 (BCO2) in rat liver and intestine
Title: Cellular localization of β-carotene 15,15' oxygenase-1 (BCO1) and β-carotene 9',10' oxygenase-2 (BCO2) in rat liver and intestine.
histone H3 K4 methylation and TRalpha-1 binding on the BCMO1 gene during the suckling-weaning transient period in rats predisposes to subsequent coactivator recruitment and histone H3 acetylation
Title: Induction of the BCMO1 gene during the suckling-weaning transition in rats is associated with histone H3 K4 methylation and subsequent coactivator binding and histone H3 acetylation to the gene.
In obese and dyslipidemic fa/fa rats, intestinal beta-Carotene 15,15'-Monooxygenase gene expression was increased, whereas hepatic lecithin:retinol acyltransferase gene expression was deceased.
Title: Altered expression of both β-carotene 15,15' monooxygenase and lecithin:retinol acyltransferase in obese Zucker rats.
study suggests that chronic alcohol intake significantly upregulates hepatic expression of beta-carotene 1515'-monooxygenase 1 (CMO1)
Title: Chronic alcohol intake upregulates hepatic expression of carotenoid cleavage enzymes and PPAR in rats.
Up-regulation of BCM gene expression in the kidneys of rats with nephrotic syndrome may result in increased conversion of beta-carotene to retinal, so this change might supply more retinoic acid to the damaged glomeruli.
Title: Expression of beta-carotene 15,15'- monooxygenase gene and retinol status in rats with puromycin aminonucleoside-induced nephrosis.
BCM gene expression in the liver, intestine and testis of Goto-Kakizaki rats was increased compared with that in controls.
Title: Expression of beta-carotene 15,15'-monooxygenase gene and retinol status in type 2 diabetic Goto-Kakizaki rats.

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General gene information

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Markers

D19Got51 (e-PCR)
- UniSTS:113698

Bcmo1 (e-PCR), detects polymorphism
- UniSTS:547962

Bcmo1 (e-PCR), detects polymorphism
- UniSTS:547963

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables beta-carotene 15,15'-dioxygenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables beta-carotene 15,15'-dioxygenase activity	IDA Inferred from Direct Assay more info	PubMed
enables beta-carotene 15,15'-dioxygenase activity	IEA Inferred from Electronic Annotation more info
enables beta-carotene 15,15'-dioxygenase activity	ISO Inferred from Sequence Orthology more info
enables carotenoid dioxygenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in beta-carotene metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within beta-carotene metabolic process	ISO Inferred from Sequence Orthology more info
involved_in carotene catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in carotene catabolic process	IEA Inferred from Electronic Annotation more info
involved_in carotene catabolic process	ISO Inferred from Sequence Orthology more info
involved_in carotene catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in retinal metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in retinal metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within retinal metabolic process	ISO Inferred from Sequence Orthology more info
involved_in retinal metabolic process	ISO Inferred from Sequence Orthology more info
involved_in retinal metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in retinoid metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in retinoid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in retinol metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: beta,beta-carotene 15,15'-dioxygenase

Names: beta,beta-carotene 15,15'-monooxygenase; beta-carotene 15, 15'-dioxygenase; beta-carotene 15, 15-dioxygenase; beta-carotene 15,15'-monooxygenase 1; beta-carotene dioxygenase 1

NP_446100.2

EC 1.13.11.63

XP_038953354.1

EC 1.13.11.63

XP_038953355.1

EC 1.13.11.63

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053648.3 → NP_446100.2 beta,beta-carotene 15,15'-dioxygenase

See identical proteins and their annotated locations for NP_446100.2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000019

UniProtKB/Swiss-Prot

Q91XT5

UniProtKB/TrEMBL

A6IZH0, G3V7N1

Related

ENSRNOP00000016880.3, ENSRNOT00000016880.7

Conserved Domains (1) summary

pfam03055
Location:11 → 519

RPE65; Retinal pigment epithelial membrane protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086037.1 Reference GRCr8

Range

62058061..62094923

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039097427.2 → XP_038953355.1 beta,beta-carotene 15,15'-dioxygenase isoform X2

Conserved Domains (1) summary

cl10080
Location:10 → 281

RPE65; Retinal pigment epithelial membrane protein
XM_039097426.2 → XP_038953354.1 beta,beta-carotene 15,15'-dioxygenase isoform X1

Conserved Domains (1) summary

cl10080
Location:42 → 391

RPE65; Retinal pigment epithelial membrane protein