Sin3b SIN3 transcription regulator family member B [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Sin3bprovided by RGD
Official Full Name: SIN3 transcription regulator family member Bprovided by RGD
Primary source: RGD:1587989
See related: EnsemblRapid:ENSRNOG00000048622 AllianceGenome:RGD:1587989
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable chromatin binding activity and transcription corepressor activity. Predicted to be involved in cardiac muscle tissue development; negative regulation of DNA-templated transcription; and skeletal muscle tissue development. Predicted to be located in several cellular components, including autosome; nucleus; and sex chromosome. Orthologous to human SIN3B (SIN3 transcription regulator family member B). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Testes (RPKM 695.4), Thymus (RPKM 379.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 16p14

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	16	NC_086034.1 (17157352..17194051, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	16	NC_051351.1 (17123277..17159978, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	16	NC_005115.4 (18842456..18860086, complement)

Chromosome 16 - NC_086034.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

interaction with Sin3B influences Na(v)-channel trafficking or stability in the membrane.
Title: Interaction between the transcriptional corepressor Sin3B and voltage-gated sodium channels modulates functional channel expression.

Submit: New GeneRIF Correction

General gene information

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Markers

RH137112 (e-PCR)
- UniSTS:219200

Sin3b (e-PCR), detects polymorphism
- UniSTS:472921

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables transcription corepressor activity	IBA Inferred from Biological aspect of Ancestor more info
enables transcription corepressor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in cardiac muscle tissue development	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in skeletal muscle tissue development	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of Sin3-type complex	IBA Inferred from Biological aspect of Ancestor more info
located_in X chromosome	ISO Inferred from Sequence Orthology more info
located_in XY body	ISO Inferred from Sequence Orthology more info
located_in Y chromosome	ISO Inferred from Sequence Orthology more info
located_in autosome	ISO Inferred from Sequence Orthology more info
located_in chromatin	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: paired amphipathic helix protein Sin3b

Names: SIN3 homolog B, transcription regulator; SIN3 transcription regulator homolog B; transcriptional regulator, SIN3B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.