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    Zdhhc3 zinc finger DHHC-type palmitoyltransferase 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 301081, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Zdhhc3provided by RGD
    Official Full Name
    zinc finger DHHC-type palmitoyltransferase 3provided by RGD
    Primary source
    RGD:1309041
    See related
    EnsemblRapid:ENSRNOG00000004344 AllianceGenome:RGD:1309041
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable protein homodimerization activity and protein-cysteine S-palmitoyltransferase activity. Predicted to be involved in several processes, including peptidyl-L-cysteine S-palmitoylation; positive regulation of cell communication; and protein localization to membrane. Predicted to act upstream of or within protein palmitoylation and protein targeting. Located in Golgi apparatus. Orthologous to human ZDHHC3 (zinc finger DHHC-type palmitoyltransferase 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 179.8), Kidney (RPKM 108.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Zdhhc3 in Genome Data Viewer
    Location:
    8q32
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (131602663..131650998, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (122725206..122773542, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (132156216..132204484, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene similar to RIKEN cDNA 1110059G10 Neighboring gene kinesin family member 15 Neighboring gene transmembrane protein 42 Neighboring gene transglutaminase 4 Neighboring gene exosome component 7 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene C-type lectin domain family 3, member B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. GODZ-mediated palmitoylation of GABA(A) receptors is required for normal assembly and function of GABAergic inhibitory synapses. Fang C, et al. J Neurosci, 2006 Dec 6. PMID 17151279, Free PMC Article
    2. Isolation and characterization of Golgi apparatus-specific GODZ with the DHHC zinc finger domain. Uemura T, et al. Biochem Biophys Res Commun, 2002 Aug 16. PMID 12163046
    3. Mobile DHHC palmitoylating enzyme mediates activity-sensitive synaptic targeting of PSD-95. Noritake J, et al. J Cell Biol, 2009 Jul 13. PMID 19596852, Free PMC Article
    4. Oligomerization of DHHC protein S-acyltransferases. Lai J, et al. J Biol Chem, 2013 Aug 2. PMID 23793055, Free PMC Article
    5. Regulation in the targeting of TRAIL receptor 1 to cell surface via GODZ for TRAIL sensitivity in tumor cells. Oh Y, et al. Cell Death Differ, 2012 Jul. PMID 22240897, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. In silico screening for palmitoyl substrates reveals a role for DHHC1/3/10 (zDHHC1/3/11)-mediated neurochondrin palmitoylation in its targeting to Rab5-positive endosomes.
      Title: In silico screening for palmitoyl substrates reveals a role for DHHC1/3/10 (zDHHC1/3/11)-mediated neurochondrin palmitoylation in its targeting to Rab5-positive endosomes.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables palmitoyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables palmitoyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-cysteine S-myristoyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-cysteine S-palmitoyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-cysteine S-palmitoyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-cysteine S-stearoyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in TRAIL-activated apoptotic signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in TRAIL-activated apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in lipoprotein localization to membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lipoprotein localization to membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in peptidyl-L-cysteine S-palmitoylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of receptor localization to synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of synaptic transmission, GABAergic ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of toll-like receptor 9 signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of toll-like receptor 9 signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to photoreceptor outer segment IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein localization to photoreceptor outer segment ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein localization to plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein localization to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within protein palmitoylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein palmitoylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within protein targeting ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein targeting to membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    palmitoyltransferase ZDHHC3
    Names
    acyltransferase ZDHHC3
    zinc finger DHHC domain-containing protein 3
    zinc finger, DHHC domain containing 3
    zinc finger, DHHC-type containing 3
    NP_001034103.1
    NP_001400507.1
    XP_038937239.1
    XP_038937240.1
    XP_038937241.1
    XP_038937242.1
    XP_038937243.1
    XP_038937244.1
    XP_038937245.1
    XP_063121382.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039014.3 → NP_001034103.1  palmitoyltransferase ZDHHC3 isoform 2

      See identical proteins and their annotated locations for NP_001034103.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/Swiss-Prot
      Q2TGK3
      UniProtKB/TrEMBL
      A0A8I6GFS0
      Related
      ENSRNOP00000111618.1, ENSRNOT00000158182.1
      Conserved Domains (1) summary
      pfam01529
      Location:128 → 255
      DHHC; DHHC palmitoyltransferase

    2. NM_001413578.1 → NP_001400507.1  palmitoyltransferase ZDHHC3 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A0A0G2K0R8, A0A8I5ZTB1
      Related
      ENSRNOP00000087183.2, ENSRNOT00000120037.2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      131602663..131650998 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039081314.1 → XP_038937242.1  palmitoyltransferase ZDHHC3 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZTB1
      Conserved Domains (1) summary
      pfam01529
      Location:128 → 253
      DHHC; DHHC palmitoyltransferase

    2. XM_039081311.1 → XP_038937239.1  palmitoyltransferase ZDHHC3 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZTB1
      Related
      ENSRNOP00000082292.2, ENSRNOT00000105271.2
      Conserved Domains (1) summary
      pfam01529
      Location:128 → 253
      DHHC; DHHC palmitoyltransferase

    3. XM_039081312.2 → XP_038937240.1  palmitoyltransferase ZDHHC3 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZTB1
      Conserved Domains (1) summary
      pfam01529
      Location:128 → 253
      DHHC; DHHC palmitoyltransferase

    4. XM_039081313.2 → XP_038937241.1  palmitoyltransferase ZDHHC3 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZTB1
      Conserved Domains (1) summary
      pfam01529
      Location:128 → 253
      DHHC; DHHC palmitoyltransferase

    5. XM_039081315.2 → XP_038937243.1  palmitoyltransferase ZDHHC3 isoform X4

      Conserved Domains (1) summary
      pfam01529
      Location:1 → 101
      DHHC; DHHC palmitoyltransferase

    6. XM_039081316.2 → XP_038937244.1  palmitoyltransferase ZDHHC3 isoform X4

      Conserved Domains (1) summary
      pfam01529
      Location:1 → 101
      DHHC; DHHC palmitoyltransferase

    7. XM_039081317.2 → XP_038937245.1  palmitoyltransferase ZDHHC3 isoform X4

      Conserved Domains (1) summary
      pfam01529
      Location:1 → 101
      DHHC; DHHC palmitoyltransferase

    8. XM_063265312.1 → XP_063121382.1  palmitoyltransferase ZDHHC3 isoform X3

      UniProtKB/Swiss-Prot
      Q2TGK3
      UniProtKB/TrEMBL
      A0A8I6GFS0
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q2TGK3.1 GenPept UniProtKB/Swiss-Prot:Q2TGK3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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