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    Senp7 SUMO specific peptidase 7 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 288167, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Senp7provided by RGD
    Official Full Name
    SUMO specific peptidase 7provided by RGD
    Primary source
    RGD:1305510
    See related
    EnsemblRapid:ENSRNOG00000001616 AllianceGenome:RGD:1305510
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable SUMO-specific endopeptidase activity. Predicted to be involved in antiviral innate immune response and protein desumoylation. Predicted to be active in nucleus; postsynaptic cytosol; and presynaptic cytosol. Orthologous to human SENP7 (SUMO specific peptidase 7). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 125.3), Spleen (RPKM 74.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Senp7 in Genome Data Viewer
    Location:
    11q12
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (57892801..58053213, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (44423733..44584129, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (46880928..47047052, complement)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene cell cycle associated protein 1, pseudogene 1 Neighboring gene interphotoreceptor matrix proteoglycan 2 Neighboring gene mitochondrial ribosomal protein L45, pseudogene 1 Neighboring gene uncharacterized LOC120095650 Neighboring gene small nucleolar RNA SNORA70 Neighboring gene tRNA methyltransferase 10C, mitochondrial RNase P subunit Neighboring gene zinc finger and BTB domain containing 11 Neighboring gene PEST proteolytic signal containing nuclear protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables SUMO-specific endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables SUMO-specific endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables SUMO-specific endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables SUMO-specific endopeptidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables cysteine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in antiviral innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in antiviral innate immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in antiviral innate immune response ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein desumoylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein desumoylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein desumoylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein desumoylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in postsynaptic cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in postsynaptic cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in presynaptic cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in presynaptic cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    sentrin-specific protease 7
    Names
    SUMO-1-specific protease 2
    SUMO1/sentrin specific peptidase 7
    SUMO1/sentrin specific protease 7
    Sumo1/sentrin/SMT3 specific peptidase 7
    sentrin/SUMO-specific protease SENP7
    NP_001099358.1
    XP_006248306.1
    XP_006248309.1
    XP_006248310.1
    XP_017453420.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001105888.2 → NP_001099358.1  sentrin-specific protease 7

      See identical proteins and their annotated locations for NP_001099358.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000011
      UniProtKB/Swiss-Prot
      D3ZF42
      UniProtKB/TrEMBL
      A0A8I5ZZQ8
      Related
      ENSRNOP00000043376.4, ENSRNOT00000044177.5
      Conserved Domains (1) summary
      cl23802
      Location:761 → 998
      Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      57892801..58053213 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006248244.5 → XP_006248306.1  sentrin-specific protease 7 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZZQ8
      Related
      ENSRNOP00000083696.2, ENSRNOT00000113252.2
      Conserved Domains (1) summary
      COG5160
      Location:749 → 1004
      ULP1; Protease, Ulp1 family [Posttranslational modification, protein turnover, chaperones]

    2. XM_006248248.5 → XP_006248310.1  sentrin-specific protease 7 isoform X4

      UniProtKB/TrEMBL
      A0A8I5ZZQ8
      Conserved Domains (1) summary
      cl23802
      Location:637 → 874
      Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain

    3. XM_017597931.3 → XP_017453420.1  sentrin-specific protease 7 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZZN8, A0A8I5ZZQ8
      Related
      ENSRNOP00000084584.1, ENSRNOT00000106202.2

    4. XM_006248247.5 → XP_006248309.1  sentrin-specific protease 7 isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZVM4, A0A8I5ZZQ8
      Related
      ENSRNOP00000082802.1, ENSRNOT00000117624.2
      Conserved Domains (1) summary
      cl23802
      Location:701 → 938
      Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    D3ZF42.1 GenPept UniProtKB/Swiss-Prot:D3ZF42

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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