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    Uggt1 UDP-glucose glycoprotein glucosyltransferase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 171129, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Uggt1provided by RGD
    Official Full Name
    UDP-glucose glycoprotein glucosyltransferase 1provided by RGD
    Primary source
    RGD:619710
    See related
    EnsemblRapid:ENSRNOG00000014901 AllianceGenome:RGD:619710
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    UGT1; Uggt; rUGT1; Ugcgl1
    Summary
    Enables UDP-glucose:glycoprotein glucosyltransferase activity and unfolded protein binding activity. Predicted to be involved in ERAD pathway and protein N-linked glycosylation via asparagine. Located in endoplasmic reticulum lumen and endoplasmic reticulum-Golgi intermediate compartment. Orthologous to human UGGT1 (UDP-glucose glycoprotein glucosyltransferase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 223.8), Thymus (RPKM 198.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Uggt1 in Genome Data Viewer
    Location:
    9q21
    Exon count:
    41
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (45851127..45964454, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (38355229..38468473, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (42692156..42805680, complement)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene Histone deacetylase 1, pseudogene 10 Neighboring gene heparan sulfate 6-O-sulfotransferase 1 Neighboring gene uncharacterized LOC100909803 Neighboring gene uncharacterized LOC102554222 Neighboring gene neuralized E3 ubiquitin protein ligase 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The recognition motif of the glycoprotein-folding sensor enzyme UDP-Glc:glycoprotein glucosyltransferase. Totani K, et al. Biochemistry, 2009 Apr 7. PMID 19222173
    2. Minor folding defects trigger local modification of glycoproteins by the ER folding sensor GT. Ritter C, et al. EMBO J, 2005 May 4. PMID 15861139, Free PMC Article
    3. Glycopeptide specificity of the secretory protein folding sensor UDP-glucose glycoprotein:glucosyltransferase. Taylor SC, et al. EMBO Rep, 2003 Apr. PMID 12671684, Free PMC Article
    4. UDP-Glc:glycoprotein glucosyltransferase recognizes structured and solvent accessible hydrophobic patches in molten globule-like folding intermediates. Caramelo JJ, et al. Proc Natl Acad Sci U S A, 2003 Jan 7. PMID 12518055, Free PMC Article
    5. Cloning and characterization of mammalian UDP-glucose glycoprotein: glucosyltransferase and the development of a specific substrate for this enzyme. Tessier DC, et al. Glycobiology, 2000 Apr. PMID 10764828

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. UGGT recognizes the hydrophobic region of client glycoproteins.
      Title: The recognition motif of the glycoprotein-folding sensor enzyme UDP-Glc:glycoprotein glucosyltransferase.
    2. how UGGT recognizes incompletely folded glycoproteins
      Title: Glycopeptide specificity of the secretory protein folding sensor UDP-glucose glycoprotein:glucosyltransferase.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables UDP-glucose:glycoprotein glucosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables UDP-glucose:glycoprotein glucosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables UDP-glucose:glycoprotein glucosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables UDP-glucose:glycoprotein glucosyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables UDP-glucose:glycoprotein glucosyltransferase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables unfolded protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables unfolded protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables unfolded protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in 'de novo' post-translational protein folding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in ERAD pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in UDP-glucosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein N-linked glycosylation via asparagine IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein folding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in protein glycosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum lumen IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum lumen IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum-Golgi intermediate compartment IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    UDP-glucose:glycoprotein glucosyltransferase 1
    Names
    RUGT
    UDP--Glc:glycoprotein glucosyltransferase
    UDP-glucose ceramide glucosyltransferase-like 1
    UDP-glucose glycoprotein: glucosyltransferase UGGT

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133596.2 → NP_598280.1  UDP-glucose:glycoprotein glucosyltransferase 1 precursor

      See identical proteins and their annotated locations for NP_598280.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/Swiss-Prot
      Q9JLA3
      UniProtKB/TrEMBL
      A6INC3
      Related
      ENSRNOP00000020558.3, ENSRNOT00000020558.7
      Conserved Domains (2) summary
      cd06432
      Location:1232 → 1479
      GT8_HUGT1_C_like; The C-terminal domain of HUGT1-like is highly homologous to the GT 8 family
      pfam06427
      Location:21 → 1178
      UDP-g_GGTase; UDP-glucose:Glycoprotein Glucosyltransferase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      45851127..45964454 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006244735.5 → XP_006244797.1  UDP-glucose:glycoprotein glucosyltransferase 1 isoform X1

      UniProtKB/Swiss-Prot
      Q9JLA3
      UniProtKB/TrEMBL
      A0A8I5ZR75, A6INC3
      Related
      ENSRNOP00000080848.1, ENSRNOT00000107876.2
      Conserved Domains (2) summary
      cd06432
      Location:1248 → 1495
      GT8_HUGT1_C_like; The C-terminal domain of HUGT1-like is highly homologous to the GT 8 family
      pfam06427
      Location:45 → 1194
      UDP-g_GGTase; UDP-glucose:Glycoprotein Glucosyltransferase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9JLA3.2 GenPept UniProtKB/Swiss-Prot:Q9JLA3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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