Gpr50 G protein-coupled receptor 50 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Gpr50provided by RGD
Official Full Name: G protein-coupled receptor 50provided by RGD
Primary source: RGD:619863
See related: EnsemblRapid:ENSRNOG00000011335 AllianceGenome:RGD:619863
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: H9
Summary: Predicted to enable melatonin receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to be located in nucleoplasm and plasma membrane. Orthologous to human GPR50 (G protein-coupled receptor 50). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 3.2), Thymus (RPKM 0.7) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: Xq37

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	X	NC_086039.1 (154413592..154419236)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	X	NC_051356.1 (149368900..149373486)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	17	NC_005116.4 (36771578..36776225)

Chromosome X - NC_086039.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

An enlarged distribution of GPR50 protein in the brain.
Title: Neuroanatomical distribution of the orphan GPR50 receptor in adult sheep and rodent brains.
the H9 melatonin-related receptor, are expressed in the adult rat testes and during development
Title: Expression of melatonin (MT1, MT2) and melatonin-related receptors in the adult rat testes and during development.
Antibodies were used to study the expression of GPR50 in mouse, rat and human hypothalamus.GPR50 immunoreactivity (ir) was observed in dorsomedial hypothalamic (DMH) cells and in cells of the ependymal layer of the third ventricle of the hypothalamus.
Title: Expression of the orphan GPR50 protein in rodent and human dorsomedial hypothalamus, tanycytes and median eminence.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables melatonin receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in postsynaptic density	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: melatonin-related receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.