Gabpa GA binding protein transcription factor subunit alpha [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Gabpaprovided by RGD
Official Full Name: GA binding protein transcription factor subunit alphaprovided by RGD
Primary source: RGD:1310802
See related: EnsemblRapid:ENSRNOG00000053205 AllianceGenome:RGD:1310802
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Nrf2a; Nrf-2alpha
Summary: Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Predicted to be involved in cell differentiation and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within blastocyst formation; negative regulation of megakaryocyte differentiation; and regulation of transcription by RNA polymerase II. Predicted to be located in chromatin and nucleoplasm. Predicted to be active in nucleus. Orthologous to human GABPA (GA binding protein transcription factor subunit alpha). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 96.3), Adrenal (RPKM 95.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 11q11

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	11	NC_086029.1 (37375040..37404060)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	11	NC_051346.1 (23888586..23917612)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	11	NC_005110.4 (24293845..24322822)

Chromosome 11 - NC_086029.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

increase in the mitochondrial biogenesis-associated transcription factor NRF-2/GABPalpha following cerebral hypoxic-ischemia in females, in contrast to the decrease observed with males
Title: Sex dependent alterations in mitochondrial electron transport chain proteins following neonatal rat cerebral hypoxic-ischemia.
Its activation enhanced by enteral glutamine mediates induction of glutathione in intestines.
Title: Enteral glutamine differentially regulates Nrf 2 along the villus-crypt axis of the intestine to enhance glutathione levels.
Nrf2a gene mutation represents an early progression of carcinogenesis in rats.
Title: Nrf2, but not β-catenin, mutation represents an early event in rat hepatocarcinogenesis.
NRF-2alpha and NRF-2beta respond to increased neuronal activity by translocating from the cytoplasm to the nucleus, where they engage in transcriptional activation of target genes.
Title: Ultrastructural study of depolarization-induced translocation of NRF-2 transcription factor in cultured rat visual cortical neurons.
GA-binding protein (GABPalpha/GABPbeta)is critical and functionally relevant Ets factor that regulates prolactin promoter activity via the basal transcription element site.
Title: Purification and mass spectrometric identification of GA-binding protein (GABP) as the functional pituitary Ets factor binding to the basal transcription element of the prolactin promoter.

Submit: New GeneRIF Correction

General gene information

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Markers

RH130478 (e-PCR)
- UniSTS:213762

Gabpa (e-PCR), detects polymorphism
- UniSTS:259081

RH130790 (e-PCR)
- UniSTS:214074

JAM2 (e-PCR)
- UniSTS:506178

RH143804 (e-PCR)
- UniSTS:233050

BF387369 (e-PCR)
- UniSTS:244321

RH133736 (e-PCR)
- UniSTS:217019

RH143705 (e-PCR)
- UniSTS:232951

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables transcription cis-regulatory region binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within blastocyst formation	ISO Inferred from Sequence Orthology more info
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within in utero embryonic development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of megakaryocyte differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in chromatin	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: GA-binding protein alpha chain

Names: GA binding protein transcription factor, alpha subunit 60kDa; GA repeat binding protein, alpha; nuclear respiratory factor 2 alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001108841.1 → NP_001102311.1 GA-binding protein alpha chain

See identical proteins and their annotated locations for NP_001102311.1

Status: PROVISIONAL

Source sequence(s)

CH473989

UniProtKB/TrEMBL

A0A8I6GML2, A6JL60, D4ACQ9

Related

ENSRNOP00000099854.1, ENSRNOT00000125355.1

Conserved Domains (3) summary

cd08534
Location:168 → 254

SAM_PNT-GABP-alpha; Sterile alpha motif (SAM)/Pointed domain of GA-binding protein (GABP) alpha chain

smart00413
Location:319 → 403

ETS; erythroblast transformation specific domain

pfam11620
Location:40 → 119

GABP-alpha; GA-binding protein alpha chain