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    Rnf135 ring finger protein 135 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 303350, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rnf135provided by RGD
    Official Full Name
    ring finger protein 135provided by RGD
    Primary source
    RGD:1305252
    See related
    EnsemblRapid:ENSRNOG00000081456 AllianceGenome:RGD:1305252
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    LRRGT00184
    Summary
    Predicted to enable several functions, including RIG-I binding activity; identical protein binding activity; and ubiquitin protein ligase activity. Predicted to be involved in several processes, including RIG-I signaling pathway; antiviral innate immune response; and protein-containing complex assembly. Predicted to be located in cytoplasmic stress granule. Predicted to be part of ribonucleoprotein complex. Predicted to be active in cytoplasm. Orthologous to human RNF135 (ring finger protein 135). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 66.0), Lung (RPKM 52.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rnf135 in Genome Data Viewer
    Location:
    10q25
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (65668441..65687671)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (65170560..65189791)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (67531989..67551237)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene ArfGAP with dual PH domains 2 Neighboring gene uncharacterized LOC134480832 Neighboring gene transfer RNA alanine (anticodon CGC) Neighboring gene ras homolog family member T1 Neighboring gene rhomboid like 3 Neighboring gene similar to human chromosome 17 open reading frame 75

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The ubiquitin ligase Riplet is essential for RIG-I-dependent innate immune responses to RNA virus infection. Oshiumi H, et al. Cell Host Microbe, 2010 Dec 16. PMID 21147464
    2. REUL is a novel E3 ubiquitin ligase and stimulator of retinoic-acid-inducible gene-I. Gao D, et al. PLoS One, 2009 Jun 1. PMID 19484123, Free PMC Article
    3. Riplet/RNF135, a RING finger protein, ubiquitinates RIG-I to promote interferon-beta induction during the early phase of viral infection. Oshiumi H, et al. J Biol Chem, 2009 Jan 9. PMID 19017631
    4. TRIM25 RING-finger E3 ubiquitin ligase is essential for RIG-I-mediated antiviral activity. Gack MU, et al. Nature, 2007 Apr 19. PMID 17392790
    5. Ube2D3 and Ube2N are essential for RIG-I-mediated MAVS aggregation in antiviral innate immunity. Shi Y, et al. Nat Commun, 2017 May 4. PMID 28469175, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RIG-I binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RIG-I binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ribonucleoprotein complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ribonucleoprotein complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ribonucleoprotein complex binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin protein ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables ubiquitin-protein transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin-protein transferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in RIG-I signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in RIG-I signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in antiviral innate immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in antiviral innate immune response ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in free ubiquitin chain polymerization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in free ubiquitin chain polymerization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of interferon-beta production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of interferon-beta production ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein K63-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein K63-linked ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein homooligomerization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein homooligomerization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein polyubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein polyubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of innate immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of innate immune response ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytoplasmic stress granule ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasmic stress granule ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of ribonucleoprotein complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of ribonucleoprotein complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase RNF135
    Names
    RING-type E3 ubiquitin transferase RNF135
    NP_001012010.1
    XP_038941951.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012010.2 → NP_001012010.1  E3 ubiquitin-protein ligase RNF135

      See identical proteins and their annotated locations for NP_001012010.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/Swiss-Prot
      Q5M929
      UniProtKB/TrEMBL
      A6HHA8
      Related
      ENSRNOP00000088068.2, ENSRNOT00000113280.2
      Conserved Domains (3) summary
      cd00162
      Location:21 → 68
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      cd12902
      Location:248 → 414
      SPRY_PRY_RNF135; PRY/SPRY domain in RING finger protein RNF135
      cl12013
      Location:79 → 214
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      65668441..65687671
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039086023.2 → XP_038941951.1  E3 ubiquitin-protein ligase RNF135 isoform X1

      Conserved Domains (2) summary
      cd12902
      Location:161 → 327
      SPRY_PRY_RNF135; PRY/SPRY domain in RING finger protein RNF135
      cl12013
      Location:27 → 127
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5M929.1 GenPept UniProtKB/Swiss-Prot:Q5M929

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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