U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Cox4i2 cytochrome c oxidase subunit 4i2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 84683, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Cox4i2provided by RGD
    Official Full Name
    cytochrome c oxidase subunit 4i2provided by RGD
    Primary source
    RGD:69422
    See related
    EnsemblRapid:ENSRNOG00000007827 AllianceGenome:RGD:69422
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Cox4b; CoxIV-2
    Summary
    Predicted to enable cytochrome-c oxidase activity. Involved in cellular response to hypoxia. Predicted to be located in mitochondrial membrane. Predicted to be part of respiratory chain complex IV. Orthologous to human COX4I2 (cytochrome c oxidase subunit 4I2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 85.6), Heart (RPKM 48.0) and 7 other tissues See more
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Cox4i2 in Genome Data Viewer
    Location:
    3q41
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (161686193..161699605)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (141228443..141239337)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (148234546..148245424)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene histocompatibility minor 13 Neighboring gene MCTS family member 2 Neighboring gene uncharacterized LOC134486187 Neighboring gene uncharacterized LOC134486188 Neighboring gene inhibitor of DNA binding 1 Neighboring gene Bcl2-like 1 Neighboring gene ribosomal protein S2, pseudogene 43 Neighboring gene small nucleolar RNA U109 Neighboring gene TPX2, microtubule nucleation factor

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Protein phosphorylation and prevention of cytochrome oxidase inhibition by ATP: coupled mechanisms of energy metabolism regulation. Acin-Perez R, et al. Cell Metab, 2011 Jun 8. PMID 21641552, Free PMC Article
    2. Cytochrome c oxidase isoform IV-2 is involved in 3-nitropropionic acid-induced toxicity in striatal astrocytes. Singh S, et al. Glia, 2009 Nov 1. PMID 19306371
    3. HIF-1α regulates COXIV subunits, a potential mechanism of self-protective response to microwave induced mitochondrial damages in neurons. Hao YH, et al. Sci Rep, 2018 Jul 10. PMID 29991768, Free PMC Article
    4. Exocrine pancreatic insufficiency, dyserythropoeitic anemia, and calvarial hyperostosis are caused by a mutation in the COX4I2 gene. Shteyer E, et al. Am J Hum Genet, 2009 Mar. PMID 19268275, Free PMC Article
    5. Undernutrition during suckling in rats elevates plasma adiponectin and its receptor in skeletal muscle regardless of diet composition: a protective effect? Prior LJ, et al. Int J Obes (Lond), 2008 Oct. PMID 18725894

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. microwave induced mitochondrial ROS production activated HIF-1alpha and regulated COXIV-1 expression to restore mitochondria functions. Therefore, HIF-1alpha might be a potential target to impair microwave induced injuries.
      Title: HIF-1α regulates COXIV subunits, a potential mechanism of self-protective response to microwave induced mitochondrial damages in neurons.
    2. mitochondrial energy metabolism regulation by phosphorylation of COXIV-1 is coupled with prevention of COX allosteric inhibition by ATP
      Title: Protein phosphorylation and prevention of cytochrome oxidase inhibition by ATP: coupled mechanisms of energy metabolism regulation.
    Submit: New GeneRIF Correction

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cytochrome-c oxidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cytochrome-c oxidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to hypoxia IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in mitochondrial electron transport, cytochrome c to oxygen IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial electron transport, cytochrome c to oxygen IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrial electron transport, cytochrome c to oxygen ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    part_of respiratory chain complex IV IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of respiratory chain complex IV IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    cytochrome c oxidase subunit 4 isoform 2, mitochondrial
    Names
    COX IV-2
    cytochrome c oxidase subunit IV
    cytochrome c oxidase, subunit 4b
    cytochrome c oxidase, subunit IVb
    NP_445924.1
    XP_006235342.1
    XP_017447568.1
    XP_038961922.1
    XP_063140800.1
    XP_063140801.1
    XP_063140802.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053472.1 → NP_445924.1  cytochrome c oxidase subunit 4 isoform 2, mitochondrial isoform 2 precursor

      See identical proteins and their annotated locations for NP_445924.1

      Status: PROVISIONAL

      Source sequence(s)
      AF255347
      UniProtKB/Swiss-Prot
      Q91Y94
      UniProtKB/TrEMBL
      A0A8L2UI91, A6KHQ9
      Conserved Domains (1) summary
      pfam02936
      Location:38 → 171
      COX4; Cytochrome c oxidase subunit IV

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      161686193..161699605
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063284731.1 → XP_063140801.1  cytochrome c oxidase subunit 4 isoform 2, mitochondrial isoform X2

      UniProtKB/Swiss-Prot
      Q91Y94
      UniProtKB/TrEMBL
      A0A8L2UI91, A6KHQ9

    2. XM_063284730.1 → XP_063140800.1  cytochrome c oxidase subunit 4 isoform 2, mitochondrial isoform X2

      UniProtKB/Swiss-Prot
      Q91Y94
      UniProtKB/TrEMBL
      A0A8L2UI91, A6KHQ9

    3. XM_006235280.4 → XP_006235342.1  cytochrome c oxidase subunit 4 isoform 2, mitochondrial isoform X2

      See identical proteins and their annotated locations for XP_006235342.1

      UniProtKB/Swiss-Prot
      Q91Y94
      UniProtKB/TrEMBL
      A0A8L2UI91, A6KHQ9
      Conserved Domains (1) summary
      pfam02936
      Location:38 → 171
      COX4; Cytochrome c oxidase subunit IV

    4. XM_017592079.2 → XP_017447568.1  cytochrome c oxidase subunit 4 isoform 2, mitochondrial isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZVG3, A6KHQ8
      Related
      ENSRNOP00000082539.1, ENSRNOT00000118018.2

    5. XM_039105994.2 → XP_038961922.1  cytochrome c oxidase subunit 4 isoform 2, mitochondrial isoform X2

      UniProtKB/Swiss-Prot
      Q91Y94
      UniProtKB/TrEMBL
      A0A8L2UI91, A6KHQ9
      Conserved Domains (1) summary
      pfam02936
      Location:38 → 171
      COX4; Cytochrome c oxidase subunit IV

    6. XM_063284732.1 → XP_063140802.1  cytochrome c oxidase subunit 4 isoform 2, mitochondrial isoform X3

      UniProtKB/TrEMBL
      A0A8L2UI91
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q91Y94.1 GenPept UniProtKB/Swiss-Prot:Q91Y94

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous